Shuo Wang

Chengyan Wang, Jun Lyu, Shuo Wang et al.

Cardiac magnetic resonance imaging (CMR) has emerged as a valuable diagnostic tool for cardiac diseases. However, a limitation of CMR is its slow imaging speed, which causes patient discomfort and introduces artifacts in the images. There has been growing interest in deep learning-based CMR imaging algorithms that can reconstruct high-quality images from highly under-sampled k-space data. However, the development of deep learning methods requires large training datasets, which have not been publicly available for CMR. To address this gap, we released a dataset that includes multi-contrast, multi-view, multi-slice and multi-coil CMR imaging data from 300 subjects. Imaging studies include cardiac cine and mapping sequences. Manual segmentations of the myocardium and chambers of all the subjects are also provided within the dataset. Scripts of state-of-the-art reconstruction algorithms were also provided as a point of reference. Our aim is to facilitate the advancement of state-of-the-art CMR image reconstruction by introducing standardized evaluation criteria and making the dataset freely accessible to the research community. Researchers can access the dataset at https://www.synapse.org/#!Synapse:syn51471091/wiki/.

Cheng Ouyang, Shuo Wang, Chen Chen et al.

Probability calibration for deep models is highly desirable in safety-critical applications such as medical imaging. It makes output probabilities of deep networks interpretable, by aligning prediction probability with the actual accuracy in test data. In image segmentation, well-calibrated probabilities allow radiologists to identify regions where model-predicted segmentations are unreliable. These unreliable predictions often occur to out-of-domain (OOD) images that are caused by imaging artifacts or unseen imaging protocols. Unfortunately, most previous calibration methods for image segmentation perform sub-optimally on OOD images. To reduce the calibration error when confronted with OOD images, we propose a novel post-hoc calibration model. Our model leverages the pixel susceptibility against perturbations at the local level, and the shape prior information at the global level. The model is tested on cardiac MRI segmentation datasets that contain unseen imaging artifacts and images from an unseen imaging protocol. We demonstrate reduced calibration errors compared with the state-of-the-art calibration algorithm.

Shuo Wang, Chen Qin, Chengyan Wang et al.

The quality of cardiac magnetic resonance (CMR) imaging is susceptible to respiratory motion artifacts. The model robustness of automated segmentation techniques in face of real-world respiratory motion artifacts is unclear. This manuscript describes the design of extreme cardiac MRI analysis challenge under respiratory motion (CMRxMotion Challenge). The challenge aims to establish a public benchmark dataset to assess the effects of respiratory motion on image quality and examine the robustness of segmentation models. The challenge recruited 40 healthy volunteers to perform different breath-hold behaviors during one imaging visit, obtaining paired cine imaging with artifacts. Radiologists assessed the image quality and annotated the level of respiratory motion artifacts. For those images with diagnostic quality, radiologists further segmented the left ventricle, left ventricle myocardium and right ventricle. The images of training set (20 volunteers) along with the annotations are released to the challenge participants, to develop an automated image quality assessment model (Task 1) and an automated segmentation model (Task 2). The images of validation set (5 volunteers) are released to the challenge participants but the annotations are withheld for online evaluation of submitted predictions. Both the images and annotations of the test set (15 volunteers) were withheld and only used for offline evaluation of submitted containerized dockers. The image quality assessment task is quantitatively evaluated by the Cohen's kappa statistics and the segmentation task is evaluated by the Dice scores and Hausdorff distances.

Meng Zhao, Yifan Hu, Ruixuan Jiang et al.

Background: To develop an artificial intelligence system that can accurately identify acute non-traumatic intracranial hemorrhage (ICH) etiology based on non-contrast CT (NCCT) scans and investigate whether clinicians can benefit from it in a diagnostic setting. Materials and Methods: The deep learning model was developed with 1868 eligible NCCT scans with non-traumatic ICH collected between January 2011 and April 2018. We tested the model on two independent datasets (TT200 and SD 98) collected after April 2018. The model's diagnostic performance was compared with clinicians's performance. We further designed a simulated study to compare the clinicians's performance with and without the deep learning system augmentation. Results: The proposed deep learning system achieved area under the receiver operating curve of 0.986 (95% CI 0.967-1.000) on aneurysms, 0.952 (0.917-0.987) on hypertensive hemorrhage, 0.950 (0.860-1.000) on arteriovenous malformation (AVM), 0.749 (0.586-0.912) on Moyamoya disease (MMD), 0.837 (0.704-0.969) on cavernous malformation (CM), and 0.839 (0.722-0.959) on other causes in TT200 dataset. Given a 90% specificity level, the sensitivities of our model were 97.1% and 90.9% for aneurysm and AVM diagnosis, respectively. The model also shows an impressive generalizability in an independent dataset SD98. The clinicians achieve significant improvements in the sensitivity, specificity, and accuracy of diagnoses of certain hemorrhage etiologies with proposed system augmentation. Conclusions: The proposed deep learning algorithms can be an effective tool for early identification of hemorrhage etiologies based on NCCT scans. It may also provide more information for clinicians for triage and further imaging examination selection.

Raghav Mehta, Angelos Filos, Ujjwal Baid et al.

Deep learning (DL) models have provided state-of-the-art performance in various medical imaging benchmarking challenges, including the Brain Tumor Segmentation (BraTS) challenges. However, the task of focal pathology multi-compartment segmentation (e.g., tumor and lesion sub-regions) is particularly challenging, and potential errors hinder translating DL models into clinical workflows. Quantifying the reliability of DL model predictions in the form of uncertainties could enable clinical review of the most uncertain regions, thereby building trust and paving the way toward clinical translation. Several uncertainty estimation methods have recently been introduced for DL medical image segmentation tasks. Developing scores to evaluate and compare the performance of uncertainty measures will assist the end-user in making more informed decisions. In this study, we explore and evaluate a score developed during the BraTS 2019 and BraTS 2020 task on uncertainty quantification (QU-BraTS) and designed to assess and rank uncertainty estimates for brain tumor multi-compartment segmentation. This score (1) rewards uncertainty estimates that produce high confidence in correct assertions and those that assign low confidence levels at incorrect assertions, and (2) penalizes uncertainty measures that lead to a higher percentage of under-confident correct assertions. We further benchmark the segmentation uncertainties generated by 14 independent participating teams of QU-BraTS 2020, all of which also participated in the main BraTS segmentation task. Overall, our findings confirm the importance and complementary value that uncertainty estimates provide to segmentation algorithms, highlighting the need for uncertainty quantification in medical image analyses. Finally, in favor of transparency and reproducibility, our evaluation code is made publicly available at: https://github.com/RagMeh11/QU-BraTS.

Shuo wang, Jihao Zhang

The rapid proliferation of online video content necessitates effective video summarization techniques. Traditional methods, often relying on a single modality (typically visual), struggle to capture the full semantic richness of videos. This paper introduces MF2Summ, a novel video summarization model based on multimodal content understanding, integrating both visual and auditory information. MF2Summ employs a five-stage process: feature extraction, cross-modal attention interaction, feature fusion, segment prediction, and key shot selection. Visual features are extracted using a pre-trained GoogLeNet model, while auditory features are derived using SoundNet. The core of our fusion mechanism involves a cross-modal Transformer and an alignment-guided self-attention Transformer, designed to effectively model inter-modal dependencies and temporal correspondences. Segment importance, location, and center-ness are predicted, followed by key shot selection using Non-Maximum Suppression (NMS) and the Kernel Temporal Segmentation (KTS) algorithm. Experimental results on the SumMe and TVSum datasets demonstrate that MF2Summ achieves competitive performance, notably improving F1-scores by 1.9\% and 0.6\% respectively over the DSNet model, and performing favorably against other state-of-the-art methods.

Chenguang Xiao, Abhirup Ghosh, Han Wu et al.

Machine unlearning, which enables a model to forget specific data upon request, is increasingly relevant in the era of privacy-centric machine learning, particularly within federated learning (FL) environments. This paper presents a pioneering study on benchmarking machine unlearning methods within a federated setting for tabular data, addressing the unique challenges posed by cross-silo FL where data privacy and communication efficiency are paramount. We explore unlearning at the feature and instance levels, employing both machine learning, random forest and logistic regression models. Our methodology benchmarks various unlearning algorithms, including fine-tuning and gradient-based approaches, across multiple datasets, with metrics focused on fidelity, certifiability, and computational efficiency. Experiments demonstrate that while fidelity remains high across methods, tree-based models excel in certifiability, ensuring exact unlearning, whereas gradient-based methods show improved computational efficiency. This study provides critical insights into the design and selection of unlearning algorithms tailored to the FL environment, offering a foundation for further research in privacy-preserving machine learning.

Fujiao Ju, Yuxuan Wang, Shuo Wang et al.

Adolescent idiopathic scoliosis (AIS), a prevalent spinal deformity, significantly affects individuals' health and quality of life. Conventional imaging techniques, such as X - rays, computed tomography (CT), and magnetic resonance imaging (MRI), offer static views of the spine. However, they are restricted in capturing the dynamic changes of the spine and its interactions with overall body motion. Therefore, developing new techniques to address these limitations has become extremely important. Dynamic digital human modeling represents a major breakthrough in digital medicine. It enables a three - dimensional (3D) view of the spine as it changes during daily activities, assisting clinicians in detecting deformities that might be missed in static imaging. Although dynamic modeling holds great potential, constructing an accurate static digital human model is a crucial initial step for high - precision simulations. In this study, our focus is on constructing an accurate static digital human model integrating the spine, which is vital for subsequent dynamic digital human research on AIS. First, we generate human point - cloud data by combining the 3D Gaussian method with the Skinned Multi - Person Linear (SMPL) model from the patient's multi - view images. Then, we fit a standard skeletal model to the generated human model. Next, we align the real spine model reconstructed from CT images with the standard skeletal model. We validated the resulting personalized spine model using X - ray data from six AIS patients, with Cobb angles (used to measure the severity of scoliosis) as evaluation metrics. The results indicate that the model's error was within 1 degree of the actual measurements. This study presents an important method for constructing digital humans.