Chao Ma

Ziyang Wang, Chao Ma

Medical image segmentation is increasingly reliant on deep learning techniques, yet the promising performance often come with high annotation costs. This paper introduces Weak-Mamba-UNet, an innovative weakly-supervised learning (WSL) framework that leverages the capabilities of Convolutional Neural Network (CNN), Vision Transformer (ViT), and the cutting-edge Visual Mamba (VMamba) architecture for medical image segmentation, especially when dealing with scribble-based annotations. The proposed WSL strategy incorporates three distinct architecture but same symmetrical encoder-decoder networks: a CNN-based UNet for detailed local feature extraction, a Swin Transformer-based SwinUNet for comprehensive global context understanding, and a VMamba-based Mamba-UNet for efficient long-range dependency modeling. The key concept of this framework is a collaborative and cross-supervisory mechanism that employs pseudo labels to facilitate iterative learning and refinement across the networks. The effectiveness of Weak-Mamba-UNet is validated on a publicly available MRI cardiac segmentation dataset with processed scribble annotations, where it surpasses the performance of a similar WSL framework utilizing only UNet or SwinUNet. This highlights its potential in scenarios with sparse or imprecise annotations. The source code is made publicly accessible.

Ziyang Wang, Jian-Qing Zheng, Chao Ma et al.

Image registration, a critical process in medical imaging, involves aligning different sets of medical imaging data into a single unified coordinate system. Deep learning networks, such as the Convolutional Neural Network (CNN)-based VoxelMorph, Vision Transformer (ViT)-based TransMorph, and State Space Model (SSM)-based MambaMorph, have demonstrated effective performance in this domain. The recent Visual State Space Model (VMamba), which incorporates a cross-scan module with SSM, has exhibited promising improvements in modeling global-range dependencies with efficient computational cost in computer vision tasks. This paper hereby introduces an exploration of VMamba with image registration, named VMambaMorph. This novel hybrid VMamba-CNN network is designed specifically for 3D image registration. Utilizing a U-shaped network architecture, VMambaMorph computes the deformation field based on target and source volumes. The VMamba-based block with 2D cross-scan module is redesigned for 3D volumetric feature processing. To overcome the complex motion and structure on multi-modality images, we further propose a fine-tune recursive registration framework. We validate VMambaMorph using a public benchmark brain MR-CT registration dataset, comparing its performance against current state-of-the-art methods. The results indicate that VMambaMorph achieves competitive registration quality. The code for VMambaMorph with all baseline methods is available on GitHub.