Haochen Zhang

Mahdi S. Hosseini, Babak Ehteshami Bejnordi, Vincent Quoc-Huy Trinh et al.

Computational Pathology CPath is an interdisciplinary science that augments developments of computational approaches to analyze and model medical histopathology images. The main objective for CPath is to develop infrastructure and workflows of digital diagnostics as an assistive CAD system for clinical pathology, facilitating transformational changes in the diagnosis and treatment of cancer that are mainly address by CPath tools. With evergrowing developments in deep learning and computer vision algorithms, and the ease of the data flow from digital pathology, currently CPath is witnessing a paradigm shift. Despite the sheer volume of engineering and scientific works being introduced for cancer image analysis, there is still a considerable gap of adopting and integrating these algorithms in clinical practice. This raises a significant question regarding the direction and trends that are undertaken in CPath. In this article we provide a comprehensive review of more than 800 papers to address the challenges faced in problem design all-the-way to the application and implementation viewpoints. We have catalogued each paper into a model-card by examining the key works and challenges faced to layout the current landscape in CPath. We hope this helps the community to locate relevant works and facilitate understanding of the field's future directions. In a nutshell, we oversee the CPath developments in cycle of stages which are required to be cohesively linked together to address the challenges associated with such multidisciplinary science. We overview this cycle from different perspectives of data-centric, model-centric, and application-centric problems. We finally sketch remaining challenges and provide directions for future technical developments and clinical integration of CPath (https://github.com/AtlasAnalyticsLab/CPath_Survey).

Haochen Zhang, Yuyang Dong, Chuan Xiao et al.

Large Language Models (LLMs), typified by OpenAI's GPT, have marked a significant advancement in artificial intelligence. Trained on vast amounts of text data, LLMs are capable of understanding and generating human-like text across a diverse range of topics. This study expands on the applications of LLMs, exploring their potential in data preprocessing, a critical stage in data mining and analytics applications. Aiming at tabular data, we delve into the applicability of state-of-the-art LLMs such as GPT-4 and GPT-4o for a series of preprocessing tasks, including error detection, data imputation, schema matching, and entity matching. Alongside showcasing the inherent capabilities of LLMs, we highlight their limitations, particularly in terms of computational expense and inefficiency. We propose an LLM-based framework for data preprocessing, which integrates cutting-edge prompt engineering techniques, coupled with traditional methods like contextualization and feature selection, to improve the performance and efficiency of these models. The effectiveness of LLMs in data preprocessing is evaluated through an experimental study spanning a variety of public datasets. GPT-4 emerged as a standout, achieving 100\% accuracy or F1 score on 4 of these datasets, suggesting LLMs' immense potential in these tasks. Despite certain limitations, our study underscores the promise of LLMs in this domain and anticipates future developments to overcome current hurdles.

Haochen Zhang, Yuyang Dong, Chuan Xiao et al.

This paper explores the utilization of LLMs for data preprocessing (DP), a crucial step in the data mining pipeline that transforms raw data into a clean format conducive to easy processing. Whereas the use of LLMs has sparked interest in devising universal solutions to DP, recent initiatives in this domain typically rely on GPT APIs, raising inevitable data breach concerns. Unlike these approaches, we consider instruction-tuning local LLMs (7 -- 13B models) as universal DP task solvers that operate on a local, single, and low-priced GPU, ensuring data security and enabling further customization. We select a collection of datasets across four representative DP tasks and construct instruction tuning data using data configuration, knowledge injection, and reasoning data distillation techniques tailored to DP. By tuning Mistral-7B, Llama 3-8B, and OpenOrca-Platypus2-13B, our models, namely, Jellyfish-7B/8B/13B, deliver competitiveness compared to GPT-3.5/4 models and strong generalizability to unseen tasks while barely compromising the base models' abilities in NLP tasks. Meanwhile, Jellyfish offers enhanced reasoning capabilities compared to GPT-3.5. Our models are available at: https://huggingface.co/NECOUDBFM/Jellyfish . Our instruction dataset is available at: https://huggingface.co/datasets/NECOUDBFM/Jellyfish-Instruct .

Bo Wen, Haochen Zhang, Dirk-Uwe G. Bartsch et al.

Topological correctness is critical for segmentation of tubular structures, which pervade in biomedical images. Existing topological segmentation loss functions are primarily based on the persistent homology of the image. They match the persistent features from the segmentation with the persistent features from the ground truth and minimize the difference between them. However, these methods suffer from an ambiguous matching problem since the matching only relies on the information in the topological space. In this work, we propose an effective and efficient Spatial-Aware Topological Loss Function that further leverages the information in the original spatial domain of the image to assist the matching of persistent features. Extensive experiments on images of various types of tubular structures show that the proposed method has superior performance in improving the topological accuracy of the segmentation compared with state-of-the-art methods. Code is available at https://github.com/JRC-VPLab/SATLoss.

Haochen Zhang, Zhong Zheng, Lingzhou Xue

We present the first gap-dependent analysis of regret and communication cost for on-policy federated $Q$-Learning in tabular episodic finite-horizon Markov decision processes (MDPs). Existing FRL methods focus on worst-case scenarios, leading to $\sqrt{T}$-type regret bounds and communication cost bounds with a $\log T$ term scaling with the number of agents $M$, states $S$, and actions $A$, where $T$ is the average total number of steps per agent. In contrast, our novel framework leverages the benign structures of MDPs, such as a strictly positive suboptimality gap, to achieve a $\log T$-type regret bound and a refined communication cost bound that disentangles exploration and exploitation. Our gap-dependent regret bound reveals a distinct multi-agent speedup pattern, and our gap-dependent communication cost bound removes the dependence on $MSA$ from the $\log T$ term. Notably, our gap-dependent communication cost bound also yields a better global switching cost when $M=1$, removing $SA$ from the $\log T$ term.

Haochen Zhang, Zhong Zheng, Lingzhou Xue

Motivated by real-world settings where data collection and policy deployment -- whether for a single agent or across multiple agents -- are costly, we study the problem of on-policy single-agent reinforcement learning (RL) and federated RL (FRL) with a focus on minimizing burn-in costs (the sample sizes needed to reach near-optimal regret) and policy switching or communication costs. In parallel finite-horizon episodic Markov Decision Processes (MDPs) with $S$ states and $A$ actions, existing methods either require superlinear burn-in costs in $S$ and $A$ or fail to achieve logarithmic switching or communication costs. We propose two novel model-free RL algorithms -- Q-EarlySettled-LowCost and FedQ-EarlySettled-LowCost -- that are the first in the literature to simultaneously achieve: (i) the best near-optimal regret among all known model-free RL or FRL algorithms, (ii) low burn-in cost that scales linearly with $S$ and $A$, and (iii) logarithmic policy switching cost for single-agent RL or communication cost for FRL. Additionally, we establish gap-dependent theoretical guarantees for both regret and switching/communication costs, improving or matching the best-known gap-dependent bounds.

Peining Zhang, Hongchen Qin, Haochen Zhang et al.

This work investigates the zero-shot forecasting capability of time series foundation models for Leaf Area Index (LAI) forecasting in agricultural monitoring. Using the HiQ dataset (U.S., 2000-2022), we systematically compare statistical baselines, a fully supervised LSTM, and the Sundial foundation model under multiple evaluation protocols. We find that Sundial, in the zero-shot setting, can outperform a fully trained LSTM provided that the input context window is sufficiently long-specifically, when covering more than one or two full seasonal cycles. We show that a general-purpose foundation model can surpass specialized supervised models on remote-sensing time series prediction without any task-specific tuning. These results highlight the strong potential of pretrained time series foundation models to serve as effective plug-and-play forecasters in agricultural and environmental applications.

Haochen Zhang, Zhong Zheng, Lingzhou Xue

We study fine-grained gap-dependent regret bounds for model-free reinforcement learning in episodic tabular Markov Decision Processes. Existing model-free algorithms achieve minimax worst-case regret, but their gap-dependent bounds remain coarse and fail to fully capture the structure of suboptimality gaps. We address this limitation by establishing fine-grained gap-dependent regret bounds for both UCB-based and non-UCB-based algorithms. In the UCB-based setting, we develop a novel analytical framework that explicitly separates the analysis of optimal and suboptimal state-action pairs, yielding the first fine-grained regret upper bound for UCB-Hoeffding (Jin et al., 2018). To highlight the generality of this framework, we introduce ULCB-Hoeffding, a new UCB-based algorithm inspired by AMB (Xu et al.,2021) but with a simplified structure, which enjoys fine-grained regret guarantees and empirically outperforms AMB. In the non-UCB-based setting, we revisit the only known algorithm AMB, and identify two key issues in its algorithm design and analysis: improper truncation in the $Q$-updates and violation of the martingale difference condition in its concentration argument. We propose a refined version of AMB that addresses these issues, establishing the first rigorous fine-grained gap-dependent regret for a non-UCB-based method, with experiments demonstrating improved performance over AMB.

Xuefeng Du, Haochen Zhang, Pengtao Xie

Learning through tests is a broadly used methodology in human learning and shows great effectiveness in improving learning outcome: a sequence of tests are made with increasing levels of difficulty; the learner takes these tests to identify his/her weak points in learning and continuously addresses these weak points to successfully pass these tests. We are interested in investigating whether this powerful learning technique can be borrowed from humans to improve the learning abilities of machines. We propose a novel learning approach called learning by passing tests (LPT). In our approach, a tester model creates increasingly more-difficult tests to evaluate a learner model. The learner tries to continuously improve its learning ability so that it can successfully pass however difficult tests created by the tester. We propose a multi-level optimization framework to formulate LPT, where the tester learns to create difficult and meaningful tests and the learner learns to pass these tests. We develop an efficient algorithm to solve the LPT problem. Our method is applied for neural architecture search and achieves significant improvement over state-of-the-art baselines on CIFAR-100, CIFAR-10, and ImageNet.

Haochen Zhang, Dong Liu, Zhiwei Xiong

Recent advances of deep learning lead to great success of image and video super-resolution (SR) methods that are based on convolutional neural networks (CNN). For video SR, advanced algorithms have been proposed to exploit the temporal correlation between low-resolution (LR) video frames, and/or to super-resolve a frame with multiple LR frames. These methods pursue higher quality of super-resolved frames, where the quality is usually measured frame by frame in e.g. PSNR. However, frame-wise quality may not reveal the consistency between frames. If an algorithm is applied to each frame independently (which is the case of most previous methods), the algorithm may cause temporal inconsistency, which can be observed as flickering. It is a natural requirement to improve both frame-wise fidelity and between-frame consistency, which are termed spatial quality and temporal quality, respectively. Then we may ask, is a method optimized for spatial quality also optimized for temporal quality? Can we optimize the two quality metrics jointly?

Dong Liu, Haochen Zhang, Zhiwei Xiong

Signal degradation is ubiquitous and computational restoration of degraded signal has been investigated for many years. Recently, it is reported that the capability of signal restoration is fundamentally limited by the perception-distortion tradeoff, i.e. the distortion and the perceptual difference between the restored signal and the ideal `original' signal cannot be made both minimal simultaneously. Distortion corresponds to signal fidelity and perceptual difference corresponds to perceptual naturalness, both of which are important metrics in practice. Besides, there is another dimension worthy of consideration, namely the semantic quality or the utility for recognition purpose, of the restored signal. In this paper, we extend the previous perception-distortion tradeoff to the case of classification-distortion-perception (CDP) tradeoff, where we introduced the classification error rate of the restored signal in addition to distortion and perceptual difference. Two versions of the CDP tradeoff are considered, one using a predefined classifier and the other dealing with the optimal classifier for the restored signal. For both versions, we can rigorously prove the existence of the CDP tradeoff, i.e. the distortion, perceptual difference, and classification error rate cannot be made all minimal simultaneously. Our findings can be useful especially for computer vision researches where some low-level vision tasks (signal restoration) serve for high-level vision tasks (visual understanding).