Xinlei Wang

Biling Wang, Michael Dohopolski, Ti Bai et al.

We evaluated the temporal performance of a deep learning (DL) based artificial intelligence (AI) model for auto segmentation in prostate radiotherapy, seeking to correlate its efficacy with changes in clinical landscapes. Our study involved 1328 prostate cancer patients who underwent definitive radiotherapy from January 2006 to August 2022 at the University of Texas Southwestern Medical Center. We trained a UNet based segmentation model on data from 2006 to 2011 and tested it on data from 2012 to 2022 to simulate real world clinical deployment. We measured the model performance using the Dice similarity coefficient (DSC), visualized the trends in contour quality using exponentially weighted moving average (EMA) curves. Additionally, we performed Wilcoxon Rank Sum Test to analyze the differences in DSC distributions across distinct periods, and multiple linear regression to investigate the impact of various clinical factors. The model exhibited peak performance in the initial phase (from 2012 to 2014) for segmenting the prostate, rectum, and bladder. However, we observed a notable decline in performance for the prostate and rectum after 2015, while bladder contour quality remained stable. Key factors that impacted the prostate contour quality included physician contouring styles, the use of various hydrogel spacer, CT scan slice thickness, MRI-guided contouring, and using intravenous (IV) contrast. Rectum contour quality was influenced by factors such as slice thickness, physician contouring styles, and the use of various hydrogel spacers. The bladder contour quality was primarily affected by using IV contrast. This study highlights the challenges in maintaining AI model performance consistency in a dynamic clinical setting. It underscores the need for continuous monitoring and updating of AI models to ensure their ongoing effectiveness and relevance in patient care.

Xinlei Wang, Maike Feng, Jing Qiu et al.

This paper introduces a novel approach that leverages Large Language Models (LLMs) and Generative Agents to enhance time series forecasting by reasoning across both text and time series data. With language as a medium, our method adaptively integrates social events into forecasting models, aligning news content with time series fluctuations to provide richer insights. Specifically, we utilize LLM-based agents to iteratively filter out irrelevant news and employ human-like reasoning to evaluate predictions. This enables the model to analyze complex events, such as unexpected incidents and shifts in social behavior, and continuously refine the selection logic of news and the robustness of the agent's output. By integrating selected news events with time series data, we fine-tune a pre-trained LLM to predict sequences of digits in time series. The results demonstrate significant improvements in forecasting accuracy, suggesting a potential paradigm shift in time series forecasting through the effective utilization of unstructured news data.

Xinlei Wang, Ruibo Ming, Jing Qiu et al.

The scaling-law era has transformed artificial intelligence from research into a global industry, but its rapid growth raises concerns over energy usage, carbon emissions, and environmental sustainability. Unlike traditional sectors, the AI industry still lacks systematic carbon accounting methods that support large-scale estimates without reproducing the original model. This leaves open questions about how large the problem is today and how large it might be in the near future. Given that the Hugging Face (HF) platform well represents the broader open-source community, we treat it as a large-scale, publicly accessible, and audit-ready corpus for carbon accounting. We propose a FLOPs-based framework to estimate aggregate training emissions of HF open-source models. Considering their uneven disclosure quality, we introduce a tiered approach to handle incomplete metadata, supported by empirical regressions that verify the statistical significance. Compute is also converted to AI training carbon intensity (ATCI, emissions per compute), a metric to assess the sustainability efficiency of model training. Our results show that training the most popular open-source models (with over 5,000 downloads) has resulted in approximately $5.8\times10^4$ metric tons of carbon emissions. This paper provides a scalable framework for emission estimations and a practical methodology to guide future standards and sustainability strategies in the AI industry.

Younghoon Kim, Tao Wang, Danyi Xiong et al.

Early detection of cancers has been much explored due to its paramount importance in biomedical fields. Among different types of data used to answer this biological question, studies based on T cell receptors (TCRs) are under recent spotlight due to the growing appreciation of the roles of the host immunity system in tumor biology. However, the one-to-many correspondence between a patient and multiple TCR sequences hinders researchers from simply adopting classical statistical/machine learning methods. There were recent attempts to model this type of data in the context of multiple instance learning (MIL). Despite the novel application of MIL to cancer detection using TCR sequences and the demonstrated adequate performance in several tumor types, there is still room for improvement, especially for certain cancer types. Furthermore, explainable neural network models are not fully investigated for this application. In this article, we propose multiple instance neural networks based on sparse attention (MINN-SA) to enhance the performance in cancer detection and explainability. The sparse attention structure drops out uninformative instances in each bag, achieving both interpretability and better predictive performance in combination with the skip connection. Our experiments show that MINN-SA yields the highest area under the ROC curve (AUC) scores on average measured across 10 different types of cancers, compared to existing MIL approaches. Moreover, we observe from the estimated attentions that MINN-SA can identify the TCRs that are specific for tumor antigens in the same T cell repertoire.

Xiyuan Zhou, Ruixi Zou, Xinlei Wang et al.

Engineering problem solving is central to real-world decision-making, requiring mathematical formulations that not only represent complex problems but also produce feasible solutions under data and physical constraints. Unlike mathematical problem solving, which operates on predefined formulations, engineering tasks demand open-ended analysis, feasibility-driven modeling, and iterative refinement. Although large language models (LLMs) have shown strong capabilities in reasoning and code generation, they often fail to ensure feasibility, which limits their applicability to engineering problem solving. To address this challenge, we propose EngiAgent, a multi-agent system with a fully connected coordinator that simulates expert workflows through specialized agents for problem analysis, modeling, verification, solving, and solution evaluation. The fully connected coordinator enables flexible feedback routing, overcoming the rigidity of prior pipeline-based reflection methods and ensuring feasibility at every stage of the process. This design not only improves robustness to diverse failure cases such as data extraction errors, constraint inconsistencies, and solver failures, but also enhances the overall quality of problem solving. Empirical results across four representative domains demonstrate that EngiAgent achieves substantial improvements in feasibility compared to prior approaches, establishing a new paradigm for feasibility-oriented engineering problem solving with LLMs. Our source code and data are available at https://github.com/AI4Engi/EngiAgent.

Xiyuan Zhou, Xinlei Wang, Yirui He et al.

Large language models (LLMs) have shown strong performance on mathematical reasoning under well-posed conditions. However, real-world engineering problems require more than mathematical symbolic computation -- they need to deal with uncertainty, context, and open-ended scenarios. Existing benchmarks fail to capture these complexities. We introduce EngiBench, a hierarchical benchmark designed to evaluate LLMs on solving engineering problems. It spans three levels of increasing difficulty (foundational knowledge retrieval, multi-step contextual reasoning, and open-ended modeling) and covers diverse engineering subfields. To facilitate a deeper understanding of model performance, we systematically rewrite each problem into three controlled variants (perturbed, knowledge-enhanced, and math abstraction), enabling us to separately evaluate the model's robustness, domain-specific knowledge, and mathematical reasoning abilities. Experiment results reveal a clear performance gap across levels: models struggle more as tasks get harder, perform worse when problems are slightly changed, and fall far behind human experts on the high-level engineering tasks. These findings reveal that current LLMs still lack the high-level reasoning needed for real-world engineering, highlighting the need for future models with deeper and more reliable problem-solving capabilities. Our source code and data are available at https://github.com/EngiBench/EngiBench.

Guangming Wang, Chi Zhang, Hesheng Wang et al.

In autonomous driving, monocular sequences contain lots of information. Monocular depth estimation, camera ego-motion estimation and optical flow estimation in consecutive frames are high-profile concerns recently. By analyzing tasks above, pixels in the middle frame are modeled into three parts: the rigid region, the non-rigid region, and the occluded region. In joint unsupervised training of depth and pose, we can segment the occluded region explicitly. The occlusion information is used in unsupervised learning of depth, pose and optical flow, as the image reconstructed by depth-pose and optical flow will be invalid in occluded regions. A less-than-mean mask is designed to further exclude the mismatched pixels interfered with by motion or illumination change in the training of depth and pose networks. This method is also used to exclude some trivial mismatched pixels in the training of the optical flow network. Maximum normalization is proposed for depth smoothness term to restrain depth degradation in textureless regions. In the occluded region, as depth and camera motion can provide more reliable motion estimation, they can be used to instruct unsupervised learning of optical flow. Our experiments in KITTI dataset demonstrate that the model based on three regions, full and explicit segmentation of the occlusion region, the rigid region, and the non-rigid region with corresponding unsupervised losses can improve performance on three tasks significantly. The source code is available at: https://github.com/guangmingw/DOPlearning.

Albert J. Zhai, Yuan Shen, Emily Y. Chen et al.

Can computers perceive the physical properties of objects solely through vision? Research in cognitive science and vision science has shown that humans excel at identifying materials and estimating their physical properties based purely on visual appearance. In this paper, we present a novel approach for dense prediction of the physical properties of objects using a collection of images. Inspired by how humans reason about physics through vision, we leverage large language models to propose candidate materials for each object. We then construct a language-embedded point cloud and estimate the physical properties of each 3D point using a zero-shot kernel regression approach. Our method is accurate, annotation-free, and applicable to any object in the open world. Experiments demonstrate the effectiveness of the proposed approach in various physical property reasoning tasks, such as estimating the mass of common objects, as well as other properties like friction and hardness.

Albert J. Zhai, Xinlei Wang, Kaiyuan Li et al.

The ability to automatically build 3D digital twins of plants from images has countless applications in agriculture, environmental science, robotics, and other fields. However, current 3D reconstruction methods fail to recover complete shapes of plants due to heavy occlusion and complex geometries. In this work, we present a novel method for 3D reconstruction of agricultural crops based on optimizing a parametric model of plant morphology via inverse procedural modeling. Our method first estimates depth maps by fitting a neural radiance field and then employs Bayesian optimization to estimate plant morphological parameters that result in consistent depth renderings. The resulting 3D model is complete and biologically plausible. We validate our method on a dataset of real images of agricultural fields, and demonstrate that the reconstructions can be used for a variety of monitoring and simulation applications.

Haoyu Chen, Keda Tao, Yizao Wang et al.

Photo retouching is integral to photographic art, extending far beyond simple technical fixes to heighten emotional expression and narrative depth. While artists leverage expertise to create unique visual effects through deliberate adjustments, non-professional users often rely on automated tools that produce visually pleasing results but lack interpretative depth and interactive transparency. In this paper, we introduce PhotoArtAgent, an intelligent system that combines Vision-Language Models (VLMs) with advanced natural language reasoning to emulate the creative process of a professional artist. The agent performs explicit artistic analysis, plans retouching strategies, and outputs precise parameters to Lightroom through an API. It then evaluates the resulting images and iteratively refines them until the desired artistic vision is achieved. Throughout this process, PhotoArtAgent provides transparent, text-based explanations of its creative rationale, fostering meaningful interaction and user control. Experimental results show that PhotoArtAgent not only surpasses existing automated tools in user studies but also achieves results comparable to those of professional human artists.

Tianhang Cheng, Albert J. Zhai, Evan Z. Chen et al.

Learning 3D parametric shape models of objects has gained popularity in vision and graphics and has showed broad utility in 3D reconstruction, generation, understanding, and simulation. While powerful models exist for humans and animals, equally expressive approaches for modeling plants are lacking. In this work, we present Demeter, a data-driven parametric model that encodes key factors of a plant morphology, including topology, shape, articulation, and deformation into a compact learned representation. Unlike previous parametric models, Demeter handles varying shape topology across various species and models three sources of shape variation: articulation, subcomponent shape variation, and non-rigid deformation. To advance crop plant modeling, we collected a large-scale, ground-truthed dataset from a soybean farm as a testbed. Experiments show that Demeter effectively synthesizes shapes, reconstructs structures, and simulates biophysical processes. Code and data is available at https://tianhang-cheng.github.io/Demeter/.

Xinlei Wang, Mingtian Tan, Jing Qiu et al.

Traditional time series analysis has long relied on pattern recognition, trained on static and well-established benchmarks. However, in real-world settings -- where policies shift, human behavior adapts, and unexpected events unfold -- effective analysis must go beyond surface-level trends to uncover the actual forces driving them. The recent rise of Large Language Models (LLMs) presents new opportunities for rethinking time series analysis by integrating multimodal inputs. However, as the use of LLMs becomes popular, we must remain cautious, asking why we use LLMs and how to exploit them effectively. Most existing LLM-based methods still employ their numerical regression ability and ignore their deeper reasoning potential. This paper argues for rethinking time series with LLMs as a reasoning task that prioritizes causal structure and explainability. This shift brings time series analysis closer to human-aligned understanding, enabling transparent and context-aware insights in complex real-world environments.

Biling Wang, Austen Maniscalco, Ti Bai et al.

Purpose: This study presents a Deep Learning (DL)-based quality assessment (QA) approach for evaluating auto-generated contours (auto-contours) in radiotherapy, with emphasis on Online Adaptive Radiotherapy (OART). Leveraging Bayesian Ordinal Classification (BOC) and calibrated uncertainty thresholds, the method enables confident QA predictions without relying on ground truth contours or extensive manual labeling. Methods: We developed a BOC model to classify auto-contour quality and quantify prediction uncertainty. A calibration step was used to optimize uncertainty thresholds that meet clinical accuracy needs. The method was validated under three data scenarios: no manual labels, limited labels, and extensive labels. For rectum contours in prostate cancer, we applied geometric surrogate labels when manual labels were absent, transfer learning when limited, and direct supervision when ample labels were available. Results: The BOC model delivered robust performance across all scenarios. Fine-tuning with just 30 manual labels and calibrating with 34 subjects yielded over 90% accuracy on test data. Using the calibrated threshold, over 93% of the auto-contours' qualities were accurately predicted in over 98% of cases, reducing unnecessary manual reviews and highlighting cases needing correction. Conclusion: The proposed QA model enhances contouring efficiency in OART by reducing manual workload and enabling fast, informed clinical decisions. Through uncertainty quantification, it ensures safer, more reliable radiotherapy workflows.

Jinjin Gu, Haoyu Chen, Guolong Liu et al.

In this paper, we present the problem formulation and methodology framework of Super-Resolution Perception (SRP) on industrial sensor data. Industrial intelligence relies on high-quality industrial sensor data for system control, diagnosis, fault detection, identification, and monitoring. However, the provision of high-quality data may be expensive in some cases. In this paper, we propose a novel machine learning problem -- the SRP problem as reconstructing high-quality data from unsatisfactory sensor data in industrial systems. Advanced generative models are then proposed to solve the SRP problem. This technology makes it possible to empower existing industrial facilities without upgrading existing sensors or deploying additional sensors. We first mathematically formulate the SRP problem under the Maximum a Posteriori (MAP) estimation framework. A case study is then presented, which performs SRP on smart meter data. A network, namely SRPNet, is proposed to generate high-frequency load data from low-frequency data. We further employ a novel recognition-based loss and relativistic adversarial loss to constraint the reconstruction of waveforms explicitly. Experiments demonstrate that our SRP model can reconstruct high-frequency data effectively. Moreover, the reconstructed high-frequency data can lead to better appliance monitoring results without changing the monitoring appliances.