Xuebin Wang, Chunxiuzi Liu, Meng Zhao et al.
This study introduces an artificial neural network (ANN) for image classification task, inspired by the aversive olfactory learning circuits of the nematode Caenorhabditis elegans (C. elegans). Despite the remarkable performance of ANNs in a variety of tasks, they face challenges such as excessive parameterization, high training costs and limited generalization capabilities. C. elegans, with its simple nervous system comprising only 302 neurons, serves as a paradigm in neurobiological research and is capable of complex behaviors including learning. This research identifies key neural circuits associated with aversive olfactory learning in C. elegans through behavioral experiments and high-throughput gene sequencing, translating them into an image classification ANN architecture. Additionally, two other image classification ANNs with distinct architectures were constructed for comparative performance analysis to highlight the advantages of bio-inspired design. The results indicate that the ANN inspired by the aversive olfactory learning circuits of C. elegans achieves higher accuracy, better consistency and faster convergence rates in image classification task, especially when tackling more complex classification challenges. This study not only showcases the potential of bio-inspired design in enhancing ANN capabilities but also provides a novel perspective and methodology for future ANN design.