Xiang Ye

Ziming Hong, Yongli Xiang, Tongliang Liu

Over the past decades, researchers have primarily focused on improving the generalization abilities of models, with limited attention given to regulating such generalization. However, the ability of models to generalize to unintended data (e.g., harmful or unauthorized data) can be exploited by malicious adversaries in unforeseen ways, potentially resulting in violations of model ethics. Non-transferable learning (NTL), a task aimed at reshaping the generalization abilities of deep learning models, was proposed to address these challenges. While numerous methods have been proposed in this field, a comprehensive review of existing progress and a thorough analysis of current limitations remain lacking. In this paper, we bridge this gap by presenting the first comprehensive survey on NTL and introducing NTLBench, the first benchmark to evaluate NTL performance and robustness within a unified framework. Specifically, we first introduce the task settings, general framework, and criteria of NTL, followed by a summary of NTL approaches. Furthermore, we emphasize the often-overlooked issue of robustness against various attacks that can destroy the non-transferable mechanism established by NTL. Experiments conducted via NTLBench verify the limitations of existing NTL methods in robustness. Finally, we discuss the practical applications of NTL, along with its future directions and associated challenges.

Yuanfang Xiang, Lun Ai

The transcriptional response to genetic perturbation reveals fundamental insights into complex cellular systems. While current approaches have made progress in predicting genetic perturbation responses, they provide limited biological understanding and cannot systematically refine existing knowledge. Overcoming these limitations requires an end-to-end integration of data-driven learning and existing knowledge. However, this integration is challenging due to inconsistencies between data and knowledge bases, such as noise, misannotation, and incompleteness. To address this challenge, we propose ALIGNED (Adaptive aLignment for Inconsistent Genetic kNowledgE and Data), a neuro-symbolic framework based on the Abductive Learning (ABL) paradigm. This end-to-end framework aligns neural and symbolic components and performs systematic knowledge refinement. We introduce a balanced consistency metric to evaluate the predictions' consistency against both data and knowledge. Our results show that ALIGNED outperforms state-of-the-art methods by achieving the highest balanced consistency, while also re-discovering biologically meaningful knowledge. Our work advances beyond existing methods to enable both the transparency and the evolution of mechanistic biological understanding.

Xiang Ye, Zihang He, Heng Wang et al.

Attention Mechanism is a widely used method for improving the performance of convolutional neural networks (CNNs) on computer vision tasks. Despite its pervasiveness, we have a poor understanding of what its effectiveness stems from. It is popularly believed that its effectiveness stems from the visual attention explanation, advocating focusing on the important part of input data rather than ingesting the entire input. In this paper, we find that there is only a weak consistency between the attention weights of features and their importance. Instead, we verify the crucial role of feature map multiplication in attention mechanism and uncover a fundamental impact of feature map multiplication on the learned landscapes of CNNs: with the high order non-linearity brought by the feature map multiplication, it played a regularization role on CNNs, which made them learn smoother and more stable landscapes near real samples compared to vanilla CNNs. This smoothness and stability induce a more predictive and stable behavior in-between real samples, and make CNNs generate better. Moreover, motivated by the proposed effectiveness of feature map multiplication, we design feature map multiplication network (FMMNet) by simply replacing the feature map addition in ResNet with feature map multiplication. FMMNet outperforms ResNet on various datasets, and this indicates that feature map multiplication plays a vital role in improving the performance even without finely designed attention mechanism in existing methods.