Yuan Gao

Luyi Han, Tao Tan, Tianyu Zhang et al.

Multi-sequence MRIs can be necessary for reliable diagnosis in clinical practice due to the complimentary information within sequences. However, redundant information exists across sequences, which interferes with mining efficient representations by modern machine learning or deep learning models. To handle various clinical scenarios, we propose a sequence-to-sequence generation framework (Seq2Seq) for imaging-differentiation representation learning. In this study, not only do we propose arbitrary 3D/4D sequence generation within one model to generate any specified target sequence, but also we are able to rank the importance of each sequence based on a new metric estimating the difficulty of a sequence being generated. Furthermore, we also exploit the generation inability of the model to extract regions that contain unique information for each sequence. We conduct extensive experiments using three datasets including a toy dataset of 20,000 simulated subjects, a brain MRI dataset of 1,251 subjects, and a breast MRI dataset of 2,101 subjects, to demonstrate that (1) our proposed Seq2Seq is efficient and lightweight for complex clinical datasets and can achieve excellent image quality; (2) top-ranking sequences can be used to replace complete sequences with non-inferior performance; (3) combining MRI with our imaging-differentiation map leads to better performance in clinical tasks such as glioblastoma MGMT promoter methylation status prediction and breast cancer pathological complete response status prediction. Our code is available at https://github.com/fiy2W/mri_seq2seq.

Tianyu Zhang, Tao Tan, Luyi Han et al.

Magnetic resonance imaging (MRI) is highly sensitive for lesion detection in the breasts. Sequences obtained with different settings can capture the specific characteristics of lesions. Such multi-parameter MRI information has been shown to improve radiologist performance in lesion classification, as well as improving the performance of artificial intelligence models in various tasks. However, obtaining multi-parameter MRI makes the examination costly in both financial and time perspectives, and there may be safety concerns for special populations, thus making acquisition of the full spectrum of MRI sequences less durable. In this study, different than naive input fusion or feature concatenation from existing MRI parameters, a novel $\textbf{I}$ntegrated MRI $\textbf{M}$ulti-$\textbf{P}$arameter reinf$\textbf{O}$rcement fusion generato$\textbf{R}$ wi$\textbf{T}$h $\textbf{A}$tte$\textbf{NT}$ion Network (IMPORTANT-Net) is developed to generate missing parameters. First, the parameter reconstruction module is used to encode and restore the existing MRI parameters to obtain the corresponding latent representation information at any scale level. Then the multi-parameter fusion with attention module enables the interaction of the encoded information from different parameters through a set of algorithmic strategies, and applies different weights to the information through the attention mechanism after information fusion to obtain refined representation information. Finally, a reinforcement fusion scheme embedded in a $V^{-}$-shape generation module is used to combine the hierarchical representations to generate the missing MRI parameter. Results showed that our IMPORTANT-Net is capable of generating missing MRI parameters and outperforms comparable state-of-the-art networks. Our code is available at https://github.com/Netherlands-Cancer-Institute/MRI_IMPORTANT_NET.

Yuan Gao, Xiang Wang, Xiangnan He et al.

Rumor detection has become an emerging and active research field in recent years. At the core is to model the rumor characteristics inherent in rich information, such as propagation patterns in social network and semantic patterns in post content, and differentiate them from the truth. However, existing works on rumor detection fall short in modeling heterogeneous information, either using one single information source only (e.g. social network, or post content) or ignoring the relations among multiple sources (e.g. fusing social and content features via simple concatenation). Therefore, they possibly have drawbacks in comprehensively understanding the rumors, and detecting them accurately. In this work, we explore contrastive self-supervised learning on heterogeneous information sources, so as to reveal their relations and characterize rumors better. Technically, we supplement the main supervised task of detection with an auxiliary self-supervised task, which enriches post representations via post self-discrimination. Specifically, given two heterogeneous views of a post (i.e. representations encoding social patterns and semantic patterns), the discrimination is done by maximizing the mutual information between different views of the same post compared to that of other posts. We devise cluster-wise and instance-wise approaches to generate the views and conduct the discrimination, considering different relations of information sources. We term this framework as Self-supervised Rumor Detection (SRD). Extensive experiments on three real-world datasets validate the effectiveness of SRD for automatic rumor detection on social media.

Xupeng Shi, Pengfei Zheng, A. Adam Ding et al.

Modern deep neural networks (DNNs) are vulnerable to adversarial attacks and adversarial training has been shown to be a promising method for improving the adversarial robustness of DNNs. Pruning methods have been considered in adversarial context to reduce model capacity and improve adversarial robustness simultaneously in training. Existing adversarial pruning methods generally mimic the classical pruning methods for natural training, which follow the three-stage 'training-pruning-fine-tuning' pipelines. We observe that such pruning methods do not necessarily preserve the dynamics of dense networks, making it potentially hard to be fine-tuned to compensate the accuracy degradation in pruning. Based on recent works of \textit{Neural Tangent Kernel} (NTK), we systematically study the dynamics of adversarial training and prove the existence of trainable sparse sub-network at initialization which can be trained to be adversarial robust from scratch. This theoretically verifies the \textit{lottery ticket hypothesis} in adversarial context and we refer such sub-network structure as \textit{Adversarial Winning Ticket} (AWT). We also show empirical evidences that AWT preserves the dynamics of adversarial training and achieve equal performance as dense adversarial training.