Haocheng Tang

Haotian Zhang, Feiyue Long, Yixin Yu et al.

Multi-view image compression (MIC) aims to achieve high compression efficiency by exploiting inter-image correlations, playing a crucial role in 3D applications. As a subfield of MIC, distributed multi-view image compression (DMIC) offers performance comparable to MIC while eliminating the need for inter-view information at the encoder side. However, existing methods in DMIC typically treat all images equally, overlooking the varying degrees of correlation between different views during decoding, which leads to suboptimal coding performance. To address this limitation, we propose a novel $\textbf{OmniParallax Attention Mechanism}$ (OPAM), which is a general mechanism for explicitly modeling correlations and aligned features between arbitrary pairs of information sources. Building upon OPAM, we propose a Parallax Multi Information Fusion Module (PMIFM) to adaptively integrate information from different sources. PMIFM is incorporated into both the joint decoder and the entropy model to construct our end-to-end DMIC framework, $\textbf{ParaHydra}$. Extensive experiments demonstrate that $\textbf{ParaHydra}$ is $\textbf{the first DMIC method}$ to significantly surpass state-of-the-art MIC codecs, while maintaining low computational overhead. Performance gains become more pronounced as the number of input views increases. Compared with LDMIC, $\textbf{ParaHydra}$ achieves bitrate savings of $\textbf{19.72%}$ on WildTrack(3) and up to $\textbf{24.18%}$ on WildTrack(6), while significantly improving coding efficiency (as much as $\textbf{65}\times$ in decoding and $\textbf{34}\times$ in encoding).

Haocheng Tang, Xingyu Dang, Junmei Wang

Optical Chemical Structure Recognition (OCSR) is critical for converting 2D molecular diagrams from printed literature into machine-readable formats. While Vision-Language Models have shown promise in end-to-end OCR tasks, their direct application to OCSR remains challenging, and direct full-parameter supervised fine-tuning often fails. In this work, we adapt DeepSeek-OCR-2 for molecular optical recognition by formulating the task as image-conditioned SMILES generation. To overcome training instabilities, we propose a two-stage progressive supervised fine-tuning strategy: starting with parameter-efficient LoRA and transitioning to selective full-parameter fine-tuning with split learning rates. We train our model on a large-scale corpus combining synthetic renderings from PubChem and realistic patent images from USPTO-MOL to improve coverage and robustness. Our fine-tuned model, MolSeek-OCR, demonstrates competitive capabilities, achieving exact matching accuracies comparable to the best-performing image-to-sequence model. However, it remains inferior to state-of-the-art image-to-graph modelS. Furthermore, we explore reinforcement-style post-training and data-curation-based refinement, finding that they fail to improve the strict sequence-level fidelity required for exact SMILES matching.

Haocheng Tang, Liang Shi, Ya-Shi Zhang et al.

Protein dynamics underlie many biological functions, yet remain difficult to characterize due to the high computational cost of molecular dynamics simulations and the scarcity of dynamic structural data. This survey reviews recent advances in artificial intelligence for protein dynamics from three perspectives: learning from structural ensembles and trajectories, learning from physical energy signals, and learning to accelerate molecular simulations. We summarize representative methods for conformation ensemble generation, trajectory generation, Boltzmann generators, physics-aware adaptation, machine learning potentials, coarse-grained modeling, and collective variable discovery. We further discuss available datasets and key open challenges, such as scalability, thermodynamic consistency, kinetic fidelity, and integration with experimental constraints.

Haocheng Tang, Ruoke Yan, Xinhui Yin et al.

Recent advances in 3D Gaussian Splatting (3DGS) have enabled fast, photorealistic rendering of dynamic 3D scenes, showing strong potential in immersive communication. However, in digital human encoding and transmission, the compression methods based on general 3DGS representations are limited by the lack of human priors, resulting in suboptimal bitrate efficiency and reconstruction quality at the decoder side, which hinders their application in streamable 3D avatar systems. We propose HGC-Avatar, a novel Hierarchical Gaussian Compression framework designed for efficient transmission and high-quality rendering of dynamic avatars. Our method disentangles the Gaussian representation into a structural layer, which maps poses to Gaussians via a StyleUNet-based generator, and a motion layer, which leverages the SMPL-X model to represent temporal pose variations compactly and semantically. This hierarchical design supports layer-wise compression, progressive decoding, and controllable rendering from diverse pose inputs such as video sequences or text. Since people are most concerned with facial realism, we incorporate a facial attention mechanism during StyleUNet training to preserve identity and expression details under low-bitrate constraints. Experimental results demonstrate that HGC-Avatar provides a streamable solution for rapid 3D avatar rendering, while significantly outperforming prior methods in both visual quality and compression efficiency.

Haocheng Tang, Jing Long, Beihong Ji et al.

In this work, we introduce Auxiliary Discriminator Sequence Generative Adversarial Networks (ADSeqGAN), a novel approach for molecular generation in small-sample datasets. Traditional generative models often struggle with limited training data, particularly in drug discovery, where molecular datasets for specific therapeutic targets, such as nucleic acids binders and central nervous system (CNS) drugs, are scarce. ADSeqGAN addresses this challenge by integrating an auxiliary random forest classifier as an additional discriminator into the GAN framework, significantly improves molecular generation quality and class specificity. Our method incorporates pretrained generator and Wasserstein distance to enhance training stability and diversity. We evaluate ADSeqGAN across three representative cases. First, on nucleic acid- and protein-targeting molecules, ADSeqGAN shows superior capability in generating nucleic acid binders compared to baseline models. Second, through oversampling, it markedly improves CNS drug generation, achieving higher yields than traditional de novo models. Third, in cannabinoid receptor type 1 (CB1) ligand design, ADSeqGAN generates novel druglike molecules, with 32.8\% predicted actives surpassing hit rates of CB1-focused and general-purpose libraries when assessed by a target-specific LRIP-SF scoring function. Overall, ADSeqGAN offers a versatile framework for molecular design in data-scarce scenarios, with demonstrated applications in nucleic acid binders, CNS drugs, and CB1 ligands.