Yimin Liu

Shuting Jin, Yi Jiang, Yimin Liu et al.

Background: Identifying new indications for approved drugs is a complex and time-consuming process that requires extensive knowledge of pharmacology, clinical data, and advanced computational methods. Recently, deep learning (DL) methods have shown their capability for the accurate prediction of drug repositioning. However, implementing DL-based modeling requires in-depth domain knowledge and proficient programming skills. Results: In this application, we introduce DeepDR, the first integrated platform that combines a variety of established DL-based models for disease- and target-specific drug repositioning tasks. DeepDR leverages invaluable experience to recommend candidate drugs, which covers more than 15 networks and a comprehensive knowledge graph that includes 5.9 million edges across 107 types of relationships connecting drugs, diseases, proteins/genes, pathways, and expression from six existing databases and a large scientific corpus of 24 million PubMed publications. Additionally, the recommended results include detailed descriptions of the recommended drugs and visualize key patterns with interpretability through a knowledge graph. Conclusion: DeepDR is free and open to all users without the requirement of registration. We believe it can provide an easy-to-use, systematic, highly accurate, and computationally automated platform for both experimental and computational scientists.

Guozheng Sun, Lei Wang, Yanhao Wang et al.

Radar automatic target recognition (RATR) based on high-resolution range profile (HRRP) has attracted increasing attention due to its ability to capture fine-grained structural features. However, recognizing targets under electronic countermeasures (ECM), especially the mainstream interrupted-sampling repeater jamming (ISRJ), remains a significant challenge, as HRRPs often suffer from serious feature distortion. To address this, we propose a robust HRRP recognition method guided by prior jamming information. Specifically, we introduce a point spread function (PSF) as prior information to model the HRRP distortion induced by ISRJ. Based on this, we design a recognition network that leverages this prior through a prior-guided feature interaction module and a hybrid loss function to enhance the model's discriminative capability. With the aid of prior information, the model can learn invariant features within distorted HRRP under different jamming parameters. Both the simulated and measured-data experiments demonstrate that our method consistently outperforms state-of-the-art approaches and exhibits stronger generalization capabilities when facing unseen jamming parameters.

Yuwei Cheng, Mengxin Jiang, Jiannan Zhu et al.

Unmanned surface vehicles (USVs) have great value with their ability to execute hazardous and time-consuming missions over water surfaces. Recently, USVs for inland waterways have attracted increasing attention for their potential application in autonomous monitoring, transportation, and cleaning. However, unlike sailing in open water, the challenges posed by scenes of inland waterways, such as the complex distribution of obstacles, the global positioning system (GPS) signal denial environment, the reflection of bank-side structures, and the fog over the water surface, all impede USV application in inland waterways. To address these problems and stimulate relevant research, we introduce USVInland, a multisensor dataset for USVs in inland waterways. The collection of USVInland spans a trajectory of more than 26 km in diverse real-world scenes of inland waterways using various modalities, including lidar, stereo cameras, millimeter-wave radar, GPS, and inertial measurement units (IMUs). Based on the requirements and challenges in the perception and navigation of USVs for inland waterways, we build benchmarks for simultaneous localization and mapping (SLAM), stereo matching, and water segmentation. We evaluate common algorithms for the above tasks to determine the influence of unique inland waterway scenes on algorithm performance. Our dataset and the development tools are available online at https://www.orca-tech.cn/datasets.html.

Yu Sang, Laixi Shi, Yimin Liu

In this paper, we propose a micro hand gesture recognition system and methods using ultrasonic active sensing. This system uses micro dynamic hand gestures for recognition to achieve human-computer interaction (HCI). The implemented system, called hand-ultrasonic gesture (HUG), consists of ultrasonic active sensing, pulsed radar signal processing, and time-sequence pattern recognition by machine learning. We adopt lower frequency (300 kHz) ultrasonic active sensing to obtain high resolution range-Doppler image features. Using high quality sequential range-Doppler features, we propose a state-transition-based hidden Markov model for gesture recognition. This method achieves a recognition accuracy of nearly 90\% by using symbolized range-Doppler features and significantly reduces the computational complexity and power consumption. Furthermore, to achieve higher classification accuracy, we utilize an end-to-end neural network model and obtain a recognition accuracy of 96.32\%. In addition to offline analysis, a real-time prototype is released to verify our method's potential for application in the real world.