Fei Tan

Ke Wang, Mariya Doneva, Jakob Meineke et al.

Magnetic Resonance Fingerprinting (MRF) is an efficient quantitative MRI technique that can extract important tissue and system parameters such as T1, T2, B0, and B1 from a single scan. This property also makes it attractive for retrospectively synthesizing contrast-weighted images. In general, contrast-weighted images like T1-weighted, T2-weighted, etc., can be synthesized directly from parameter maps through spin-dynamics simulation (i.e., Bloch or Extended Phase Graph models). However, these approaches often exhibit artifacts due to imperfections in the mapping, the sequence modeling, and the data acquisition. Here we propose a supervised learning-based method that directly synthesizes contrast-weighted images from the MRF data without going through the quantitative mapping and spin-dynamics simulation. To implement our direct contrast synthesis (DCS) method, we deploy a conditional Generative Adversarial Network (GAN) framework and propose a multi-branch U-Net as the generator. The input MRF data are used to directly synthesize T1-weighted, T2-weighted, and fluid-attenuated inversion recovery (FLAIR) images through supervised training on paired MRF and target spin echo-based contrast-weighted scans. In-vivo experiments demonstrate excellent image quality compared to simulation-based contrast synthesis and previous DCS methods, both visually as well as by quantitative metrics. We also demonstrate cases where our trained model is able to mitigate in-flow and spiral off-resonance artifacts that are typically seen in MRF reconstructions and thus more faithfully represent conventional spin echo-based contrast-weighted images.

Xuejing Liu, Wei Tang, Xinzhe Ni et al.

Text-rich VQA, namely Visual Question Answering based on text recognition in the images, is a cross-modal task that requires both image comprehension and text recognition. In this work, we focus on investigating the advantages and bottlenecks of LLM-based approaches in addressing this problem. To address the above concern, we separate the vision and language modules, where we leverage external OCR models to recognize texts in the image and Large Language Models (LLMs) to answer the question given texts. The whole framework is training-free benefiting from the in-context ability of LLMs. This pipeline achieved superior performance compared to the majority of existing Multimodal Large Language Models (MLLM) on four text-rich VQA datasets. Besides, based on the ablation study, we find that LLM brings stronger comprehension ability and may introduce helpful knowledge for the VQA problem. The bottleneck for LLM to address text-rich VQA problems may primarily lie in visual part. We also combine the OCR module with MLLMs and pleasantly find that the combination of OCR module with MLLM also works. It's worth noting that not all MLLMs can comprehend the OCR information, which provides insights into how to train an MLLM that preserves the abilities of LLM.

Fei Tan, Ashok Vardhan Addala, Bruno Astuto Arouche Nunes et al.

Medical imaging datasets often suffer from class imbalance and limited availability of pathology-rich cases, which constrains the performance of machine learning models for segmentation, classification, and vision-language tasks. To address this challenge, we propose POWDR, a pathology-preserving outpainting framework for 3D MRI based on a conditioned wavelet diffusion model. Unlike conventional augmentation or unconditional synthesis, POWDR retains real pathological regions while generating anatomically plausible surrounding tissue, enabling diversity without fabricating lesions. Our approach leverages wavelet-domain conditioning to enhance high-frequency detail and mitigate blurring common in latent diffusion models. We introduce a random connected mask training strategy to overcome conditioning-induced collapse and improve diversity outside the lesion. POWDR is evaluated on brain MRI using BraTS datasets and extended to knee MRI to demonstrate tissue-agnostic applicability. Quantitative metrics (FID, SSIM, LPIPS) confirm image realism, while diversity analysis shows significant improvement with random-mask training (cosine similarity reduced from 0.9947 to 0.9580; KL divergence increased from 0.00026 to 0.01494). Clinically relevant assessments reveal gains in tumor segmentation performance using nnU-Net, with Dice scores improving from 0.6992 to 0.7137 when adding 50 synthetic cases. Tissue volume analysis indicates no significant differences for CSF and GM compared to real images. These findings highlight POWDR as a practical solution for addressing data scarcity and class imbalance in medical imaging. The method is extensible to multiple anatomies and offers a controllable framework for generating diverse, pathology-preserving synthetic data to support robust model development.

Shiqi Wang, Zhengze Zhang, Rui Zhao et al.

With the rapid advances in Large Language Models (LLMs), aligning LLMs with human preferences become increasingly important. Although Reinforcement Learning with Human Feedback (RLHF) proves effective, it is complicated and highly resource-intensive. As such, offline RLHF has been introduced as an alternative solution, which directly optimizes LLMs with ranking losses on a fixed preference dataset. Current offline RLHF only captures the "ordinal relationship" between responses, overlooking the crucial aspect of how much one is preferred over the others. To address this issue, we propose a simple yet effective solution called Reward Difference Optimization, shorted as RDO. Specifically, we introduce reward difference coefficients to reweigh sample pairs in offline RLHF. We then develop a difference model which captures rich interactions between a pair of responses for predicting these difference coefficients. Experiments with 7B LLMs on the HH and TL;DR datasets substantiate the effectiveness of our method in both automatic metrics and human evaluation, thereby highlighting its potential for aligning LLMs with human intent and values

Yike Zhao, Simin Guo, Ziqing Yang et al.

The reasoning capabilities of Large Language Models (LLMs) play a critical role in many downstream tasks, yet depend strongly on the quality of training data. Despite various proposed data construction methods, their practical utility in real-world pipelines remains underexplored. In this work, we conduct a comprehensive analysis of open-source datasets and data synthesis techniques for mathematical reasoning, evaluating them under a unified pipeline designed to mirror training and deployment scenarios. We further distill effective data selection strategies and identify practical methods suitable for industrial applications. Our findings highlight that structuring data in more interpretable formats, or distilling from stronger models often outweighs simply scaling up data volume. This study provides actionable guidance for integrating training data to enhance LLM capabilities, supporting both cost-effective data curation and scalable model enhancement. We hope this work will inspire further research on how to balance "more data" versus "better data" for real-world reasoning tasks.

Xuejing Liu, Wei Tang, Jinghui Lu et al.

Recent advancements in multimodal foundation models (e.g., CLIP) have excelled in zero-shot generalization. Prompt tuning involved in the knowledge transfer from foundation models to downstream tasks has gained significant attention recently. Existing prompt-tuning methods in cross-modal learning, however, either solely focus on language branch, or learn vision-language interaction in a shallow mechanism. In this context, we propose a Deeply coupled Cross-modal Prompt learning (DCP) method based on CLIP. DCP flexibly accommodates the interplay between vision and language with a Cross-Modal Prompt Attention (CMPA) mechanism, which enables the mutual exchange of respective representation through a well-connected multi-head attention module progressively and strongly. We then conduct comprehensive few-shot learning experiments on 11 image classification datasets and analyze the robustness to domain shift as well. Thorough experimental analysis evidently demonstrates the superb few-shot generalization and compelling domain adaption capacity of a well-executed DCP. The code can be found at https://github.com/GingL/CMPA.