Lin Yang

Sandhini Agarwal, Lama Ahmad, Jason Ai et al. · openai

We present gpt-oss-120b and gpt-oss-20b, two open-weight reasoning models that push the frontier of accuracy and inference cost. The models use an efficient mixture-of-expert transformer architecture and are trained using large-scale distillation and reinforcement learning. We optimize the models to have strong agentic capabilities (deep research browsing, python tool use, and support for developer-provided functions), all while using a rendered chat format that enables clear instruction following and role delineation. Both models achieve strong results on benchmarks ranging from mathematics, coding, and safety. We release the model weights, inference implementations, tool environments, and tokenizers under an Apache 2.0 license to enable broad use and further research.

Honglin Li, Chenglu Zhu, Yunlong Zhang et al.

While Multiple Instance Learning (MIL) has shown promising results in digital Pathology Whole Slide Image (WSI) classification, such a paradigm still faces performance and generalization problems due to challenges in high computational costs on Gigapixel WSIs and limited sample size for model training. To deal with the computation problem, most MIL methods utilize a frozen pretrained model from ImageNet to obtain representations first. This process may lose essential information owing to the large domain gap and hinder the generalization of model due to the lack of image-level training-time augmentations. Though Self-supervised Learning (SSL) proposes viable representation learning schemes, the improvement of the downstream task still needs to be further explored in the conversion from the task-agnostic features of SSL to the task-specifics under the partial label supervised learning. To alleviate the dilemma of computation cost and performance, we propose an efficient WSI fine-tuning framework motivated by the Information Bottleneck theory. The theory enables the framework to find the minimal sufficient statistics of WSI, thus supporting us to fine-tune the backbone into a task-specific representation only depending on WSI-level weak labels. The WSI-MIL problem is further analyzed to theoretically deduce our fine-tuning method. Our framework is evaluated on five pathology WSI datasets on various WSI heads. The experimental results of our fine-tuned representations show significant improvements in both accuracy and generalization compared with previous works. Source code will be available at https://github.com/invoker-LL/WSI-finetuning.

Aaditya Singh, Adam Fry, Adam Perelman et al. · berkeley, mila

This is the system card published alongside the OpenAI GPT-5 launch, August 2025. GPT-5 is a unified system with a smart and fast model that answers most questions, a deeper reasoning model for harder problems, and a real-time router that quickly decides which model to use based on conversation type, complexity, tool needs, and explicit intent (for example, if you say 'think hard about this' in the prompt). The router is continuously trained on real signals, including when users switch models, preference rates for responses, and measured correctness, improving over time. Once usage limits are reached, a mini version of each model handles remaining queries. This system card focuses primarily on gpt-5-thinking and gpt-5-main, while evaluations for other models are available in the appendix. The GPT-5 system not only outperforms previous models on benchmarks and answers questions more quickly, but -- more importantly -- is more useful for real-world queries. We've made significant advances in reducing hallucinations, improving instruction following, and minimizing sycophancy, and have leveled up GPT-5's performance in three of ChatGPT's most common uses: writing, coding, and health. All of the GPT-5 models additionally feature safe-completions, our latest approach to safety training to prevent disallowed content. Similarly to ChatGPT agent, we have decided to treat gpt-5-thinking as High capability in the Biological and Chemical domain under our Preparedness Framework, activating the associated safeguards. While we do not have definitive evidence that this model could meaningfully help a novice to create severe biological harm -- our defined threshold for High capability -- we have chosen to take a precautionary approach.

Yunlong Zhang, Yuxuan Sun, Honglin Li et al.

When designing a diagnostic model for a clinical application, it is crucial to guarantee the robustness of the model with respect to a wide range of image corruptions. Herein, an easy-to-use benchmark is established to evaluate how deep neural networks perform on corrupted pathology images. Specifically, corrupted images are generated by injecting nine types of common corruptions into validation images. Besides, two classification and one ranking metrics are designed to evaluate the prediction and confidence performance under corruption. Evaluated on two resulting benchmark datasets, we find that (1) a variety of deep neural network models suffer from a significant accuracy decrease (double the error on clean images) and the unreliable confidence estimation on corrupted images; (2) A low correlation between the validation and test errors while replacing the validation set with our benchmark can increase the correlation. Our codes are available on https://github.com/superjamessyx/robustness_benchmark.

Yunlong Zhang, Xin Lin, Yihong Zhuang et al.

Synthesizing a subject-specific pathology-free image from a pathological image is valuable for algorithm development and clinical practice. In recent years, several approaches based on the Generative Adversarial Network (GAN) have achieved promising results in pseudo-healthy synthesis. However, the discriminator (i.e., a classifier) in the GAN cannot accurately identify lesions and further hampers from generating admirable pseudo-healthy images. To address this problem, we present a new type of discriminator, the segmentor, to accurately locate the lesions and improve the visual quality of pseudo-healthy images. Then, we apply the generated images into medical image enhancement and utilize the enhanced results to cope with the low contrast problem existing in medical image segmentation. Furthermore, a reliable metric is proposed by utilizing two attributes of label noise to measure the health of synthetic images. Comprehensive experiments on the T2 modality of BraTS demonstrate that the proposed method substantially outperforms the state-of-the-art methods. The method achieves better performance than the existing methods with only 30\% of the training data. The effectiveness of the proposed method is also demonstrated on the LiTS and the T1 modality of BraTS. The code and the pre-trained model of this study are publicly available at https://github.com/Au3C2/Generator-Versus-Segmentor.

Yu-Zhen Janice Chen, Lin Yang, Xuchuang Wang et al. · uw

This paper studies a cooperative multi-agent multi-armed stochastic bandit problem where agents operate asynchronously -- agent pull times and rates are unknown, irregular, and heterogeneous -- and face the same instance of a K-armed bandit problem. Agents can share reward information to speed up the learning process at additional communication costs. We propose ODC, an on-demand communication protocol that tailors the communication of each pair of agents based on their empirical pull times. ODC is efficient when the pull times of agents are highly heterogeneous, and its communication complexity depends on the empirical pull times of agents. ODC is a generic protocol that can be integrated into most cooperative bandit algorithms without degrading their performance. We then incorporate ODC into the natural extensions of UCB and AAE algorithms and propose two communication-efficient cooperative algorithms. Our analysis shows that both algorithms are near-optimal in regret.

Matthias Eisenmann, Annika Reinke, Vivienn Weru et al. · utoronto

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

Boyu Tan, Jiarui Guo, Zongwei Lv et al.

Large Language Models (LLMs) have revolutionized AI applications, but deploying them at scale presents significant challenges. We present RTP-LLM, a high-performance inference engine for industrial-scale LLM deployment, successfully deployed across Alibaba Group serving over 100 million users. RTP-LLM addresses fundamental bottlenecks through integrated design. It optimizes model loading via file-order-driven I/O and parallel I/O-communication overlapping. The Prefill-Decode Disaggregation architecture decouples compute-intensive prefill from memory-bound decode phases, combined with hierarchical multi-tiered KV cache management enabling efficient cache reuse. In addition, RTP-LLM incorporates modular speculative decoding supporting multiple algorithms, adaptive KV cache quantization, and decoupled multimodal processing, with support for multi-level parallelism. Comprehensive evaluations across diverse model architectures (8B-235B parameters) have been conducted, where both controlled benchmarks and real production workloads are used. The results demonstrate RTP-LLM's superior performance against vLLM and SGLang: 4.7x-6.3x model loading speedup, 35-37% TTFT P95 latency reduction with 215% cache reuse improvement in production traffic scheduling, 1.12x-2.48x and 1.86x-2.52x throughput improvements in speculative decoding and multimodal inference, respectively, and 35-40% batch latency reduction with 1.9x-3.0x TTFT improvement in quantized inference. RTP-LLM's production-proven architecture and open-source availability make it a comprehensive solution for industrial LLM deployment.

Yunlong Zhang, Honglin Li, Yuxuan Sun et al.

In the application of Multiple Instance Learning (MIL) methods for Whole Slide Image (WSI) classification, attention mechanisms often focus on a subset of discriminative instances, which are closely linked to overfitting. To mitigate overfitting, we present Attention-Challenging MIL (ACMIL). ACMIL combines two techniques based on separate analyses for attention value concentration. Firstly, UMAP of instance features reveals various patterns among discriminative instances, with existing attention mechanisms capturing only some of them. To remedy this, we introduce Multiple Branch Attention (MBA) to capture more discriminative instances using multiple attention branches. Secondly, the examination of the cumulative value of Top-K attention scores indicates that a tiny number of instances dominate the majority of attention. In response, we present Stochastic Top-K Instance Masking (STKIM), which masks out a portion of instances with Top-K attention values and allocates their attention values to the remaining instances. The extensive experimental results on three WSI datasets with two pre-trained backbones reveal that our ACMIL outperforms state-of-the-art methods. Additionally, through heatmap visualization and UMAP visualization, this paper extensively illustrates ACMIL's effectiveness in suppressing attention value concentration and overcoming the overfitting challenge. The source code is available at \url{https://github.com/dazhangyu123/ACMIL}.

Shawn Xu, Lin Yang, Christopher Kelly et al.

In this work, we present an approach, which we call Embeddings for Language/Image-aligned X-Rays, or ELIXR, that leverages a language-aligned image encoder combined or grafted onto a fixed LLM, PaLM 2, to perform a broad range of chest X-ray tasks. We train this lightweight adapter architecture using images paired with corresponding free-text radiology reports from the MIMIC-CXR dataset. ELIXR achieved state-of-the-art performance on zero-shot chest X-ray (CXR) classification (mean AUC of 0.850 across 13 findings), data-efficient CXR classification (mean AUCs of 0.893 and 0.898 across five findings (atelectasis, cardiomegaly, consolidation, pleural effusion, and pulmonary edema) for 1% (~2,200 images) and 10% (~22,000 images) training data), and semantic search (0.76 normalized discounted cumulative gain (NDCG) across nineteen queries, including perfect retrieval on twelve of them). Compared to existing data-efficient methods including supervised contrastive learning (SupCon), ELIXR required two orders of magnitude less data to reach similar performance. ELIXR also showed promise on CXR vision-language tasks, demonstrating overall accuracies of 58.7% and 62.5% on visual question answering and report quality assurance tasks, respectively. These results suggest that ELIXR is a robust and versatile approach to CXR AI.

Pingyi Chen, Chenglu Zhu, Sunyi Zheng et al.

Whole slide imaging is routinely adopted for carcinoma diagnosis and prognosis. Abundant experience is required for pathologists to achieve accurate and reliable diagnostic results of whole slide images (WSI). The huge size and heterogeneous features of WSIs make the workflow of pathological reading extremely time-consuming. In this paper, we propose a novel framework (WSI-VQA) to interpret WSIs by generative visual question answering. WSI-VQA shows universality by reframing various kinds of slide-level tasks in a question-answering pattern, in which pathologists can achieve immunohistochemical grading, survival prediction, and tumor subtyping following human-machine interaction. Furthermore, we establish a WSI-VQA dataset which contains 8672 slide-level question-answering pairs with 977 WSIs. Besides the ability to deal with different slide-level tasks, our generative model which is named Wsi2Text Transformer (W2T) outperforms existing discriminative models in medical correctness, which reveals the potential of our model to be applied in the clinical scenario. Additionally, we also visualize the co-attention mapping between word embeddings and WSIs as an intuitive explanation for diagnostic results. The dataset and related code are available at https://github.com/cpystan/WSI-VQA.

Zhongyi Shui, Yunlong Zhang, Kai Yao et al.

Nucleus instance segmentation in histology images is crucial for a broad spectrum of clinical applications. Current dominant algorithms rely on regression of nuclear proxy maps. Distinguishing nucleus instances from the estimated maps requires carefully curated post-processing, which is error-prone and parameter-sensitive. Recently, the Segment Anything Model (SAM) has earned huge attention in medical image segmentation, owing to its impressive generalization ability and promptable property. Nevertheless, its potential on nucleus instance segmentation remains largely underexplored. In this paper, we present a novel prompt-driven framework that consists of a nucleus prompter and SAM for automatic nucleus instance segmentation. Specifically, the prompter learns to generate a unique point prompt for each nucleus while the SAM is fine-tuned to output the corresponding mask for the prompted nucleus. Furthermore, we propose the inclusion of adjacent nuclei as negative prompts to enhance the model's capability to identify overlapping nuclei. Without complicated post-processing, our proposed method sets a new state-of-the-art performance on three challenging benchmarks. Code is available at \url{github.com/windygoo/PromptNucSeg}

Lin Yang, Qilong Zhai

This paper is devoted to construction and convergence analysis of the linear explicit immersed finite element (IFE) function. For the interface elements, the proposed IFE functions precisely satisfy the interface conditions on the actual interface. The IFE functions are constructed in an explicit form and can be obtained directly without solving any auxiliary problems or local linear systems. Although the constructed IFE functions are non-polynomial, we establish rigorous theoretical analysis showing that they achieve optimal approximation properties and satisfy the essential trace inequalities. And the constants in the analysis are independent of how the interface cuts through the elements. Based on these IFE functions, an immersed discontinuous Galerkin numerical scheme is developed. Several numerical experiments are implemented to confirm that both the IFE functions and the numerical method achieve optimal convergence rates in the $H^1$ and $L^2$ norms. Furthermore, the numerical results indicate that the condition numbers of the stiffness matrices are robust with respect to the interface location.

Yunhao Li, Zhen Xiao, Lin Yang et al.

Multi-object tracking (MOT) is a fundamental problem in computer vision with numerous applications, such as intelligent surveillance and automated driving. Despite the significant progress made in MOT, pedestrian attributes, such as gender, hairstyle, body shape, and clothing features, which contain rich and high-level information, have been less explored. To address this gap, we propose a simple, effective, and generic method to predict pedestrian attributes to support general Re-ID embedding. We first introduce AttMOT, a large, highly enriched synthetic dataset for pedestrian tracking, containing over 80k frames and 6 million pedestrian IDs with different time, weather conditions, and scenarios. To the best of our knowledge, AttMOT is the first MOT dataset with semantic attributes. Subsequently, we explore different approaches to fuse Re-ID embedding and pedestrian attributes, including attention mechanisms, which we hope will stimulate the development of attribute-assisted MOT. The proposed method AAM demonstrates its effectiveness and generality on several representative pedestrian multi-object tracking benchmarks, including MOT17 and MOT20, through experiments on the AttMOT dataset. When applied to state-of-the-art trackers, AAM achieves consistent improvements in MOTA, HOTA, AssA, IDs, and IDF1 scores. For instance, on MOT17, the proposed method yields a +1.1 MOTA, +1.7 HOTA, and +1.8 IDF1 improvement when used with FairMOT. To encourage further research on attribute-assisted MOT, we will release the AttMOT dataset.

Zhongyi Shui, Sunyi Zheng, Chenglu Zhu et al.

Point-based cell detection (PCD), which pursues high-performance cell sensing under low-cost data annotation, has garnered increased attention in computational pathology community. Unlike mainstream PCD methods that rely on intermediate density map representations, the Point-to-Point network (P2PNet) has recently emerged as an end-to-end solution for PCD, demonstrating impressive cell detection accuracy and efficiency. Nevertheless, P2PNet is limited to decoding from a single-level feature map due to the scale-agnostic property of point proposals, which is insufficient to leverage multi-scale information. Moreover, the spatial distribution of pre-set point proposals is biased from that of cells, leading to inaccurate cell localization. To lift these limitations, we present DPA-P2PNet in this work. The proposed method directly extracts multi-scale features for decoding according to the coordinates of point proposals on hierarchical feature maps. On this basis, we further devise deformable point proposals to mitigate the positional bias between proposals and potential cells to promote cell localization. Inspired by practical pathological diagnosis that usually combines high-level tissue structure and low-level cell morphology for accurate cell classification, we propose a multi-field-of-view (mFoV) variant of DPA-P2PNet to accommodate additional large FoV images with tissue information as model input. Finally, we execute the first self-supervised pre-training on immunohistochemistry histopathology image data and evaluate the suitability of four representative self-supervised methods on the PCD task. Experimental results on three benchmarks and a large-scale and real-world interval dataset demonstrate the superiority of our proposed models over the state-of-the-art counterparts. Codes and pre-trained weights will be available.

Yunlong Zhang, Yuxuan Sun, Sunyi Zheng et al.

Although deep learning-based segmentation models have achieved impressive performance on public benchmarks, generalizing well to unseen environments remains a major challenge. To improve the model's generalization ability to the new domain during evaluation, the test-time training (TTT) is a challenging paradigm that adapts the source-pretrained model in an online fashion. Early efforts on TTT mainly focus on the image classification task. Directly extending these methods to semantic segmentation easily experiences unstable adaption due to segmentation's inherent characteristics, such as extreme class imbalance and complex decision spaces. To stabilize the adaptation process, we introduce contrastive loss (CL), known for its capability to learn robust and generalized representations. Nevertheless, the traditional CL operates in the representation space and cannot directly enhance predictions. In this paper, we resolve this limitation by adapting the CL to the output space, employing a high temperature, and simplifying the formulation, resulting in a straightforward yet effective loss function called Output Contrastive Loss (OCL). Our comprehensive experiments validate the efficacy of our approach across diverse evaluation scenarios. Notably, our method excels even when applied to models initially pre-trained using domain adaptation methods on test domain data, showcasing its resilience and adaptability.\footnote{Code and more information could be found at~ \url{https://github.com/dazhangyu123/OCL}}

Yunfan Li, Yiran Wang, Yu Cheng et al.

Policy optimization methods are powerful algorithms in Reinforcement Learning (RL) for their flexibility to deal with policy parameterization and ability to handle model misspecification. However, these methods usually suffer from slow convergence rates and poor sample complexity. Hence it is important to design provably sample efficient algorithms for policy optimization. Yet, recent advances for this problems have only been successful in tabular and linear setting, whose benign structures cannot be generalized to non-linearly parameterized policies. In this paper, we address this problem by leveraging recent advances in value-based algorithms, including bounded eluder-dimension and online sensitivity sampling, to design a low-switching sample-efficient policy optimization algorithm, LPO, with general non-linear function approximation. We show that, our algorithm obtains an $\varepsilon$-optimal policy with only $\widetilde{O}(\frac{\text{poly}(d)}{\varepsilon^3})$ samples, where $\varepsilon$ is the suboptimality gap and $d$ is a complexity measure of the function class approximating the policy. This drastically improves previously best-known sample bound for policy optimization algorithms, $\widetilde{O}(\frac{\text{poly}(d)}{\varepsilon^8})$. Moreover, we empirically test our theory with deep neural nets to show the benefits of the theoretical inspiration.

Pingyi Chen, Chenglu Zhu, Zhongyi Shui et al.

The success of supervised deep learning models in medical image segmentation relies on detailed annotations. However, labor-intensive manual labeling is costly and inefficient, especially in dense object segmentation. To this end, we propose a self-supervised learning based approach with a Prior Self-activation Module (PSM) that generates self-activation maps from the input images to avoid labeling costs and further produce pseudo masks for the downstream task. To be specific, we firstly train a neural network using self-supervised learning and utilize the gradient information in the shallow layers of the network to generate self-activation maps. Afterwards, a semantic-guided generator is then introduced as a pipeline to transform visual representations from PSM to pixel-level semantic pseudo masks for downstream tasks. Furthermore, a two-stage training module, consisting of a nuclei detection network and a nuclei segmentation network, is adopted to achieve the final segmentation. Experimental results show the effectiveness on two public pathological datasets. Compared with other fully-supervised and weakly-supervised methods, our method can achieve competitive performance without any manual annotations.

Zhongyi Shui, Yizhi Zhao, Sunyi Zheng et al.

Cell recognition is a fundamental task in digital histopathology image analysis. Point-based cell recognition (PCR) methods normally require a vast number of annotations, which is extremely costly, time-consuming and labor-intensive. Semi-supervised learning (SSL) can provide a shortcut to make full use of cell information in gigapixel whole slide images without exhaustive labeling. However, research into semi-supervised point-based cell recognition (SSPCR) remains largely overlooked. Previous SSPCR works are all built on density map-based PCR models, which suffer from unsatisfactory accuracy, slow inference speed and high sensitivity to hyper-parameters. To address these issues, end-to-end PCR models are proposed recently. In this paper, we develop a SSPCR framework suitable for the end-to-end PCR models for the first time. Overall, we use the current models to generate pseudo labels for unlabeled images, which are in turn utilized to supervise the models training. Besides, we introduce a co-teaching strategy to overcome the confirmation bias problem that generally exists in self-training. A distribution alignment technique is also incorporated to produce high-quality, unbiased pseudo labels for unlabeled data. Experimental results on four histopathology datasets concerning different types of staining styles show the effectiveness and versatility of the proposed framework. Code is available at \textcolor{magenta}{\url{https://github.com/windygooo/SSPCR}

Lin Yang, Xuchuang Wang, Mohammad Hajiesmaili et al.

Recently, there has been extensive study of cooperative multi-agent multi-armed bandits where a set of distributed agents cooperatively play the same multi-armed bandit game. The goal is to develop bandit algorithms with the optimal group and individual regrets and low communication between agents. The prior work tackled this problem using two paradigms: leader-follower and fully distributed algorithms. Prior algorithms in both paradigms achieve the optimal group regret. The leader-follower algorithms achieve constant communication costs but fail to achieve optimal individual regrets. The state-of-the-art fully distributed algorithms achieve optimal individual regrets but fail to achieve constant communication costs. This paper presents a simple yet effective communication policy and integrates it into a learning algorithm for cooperative bandits. Our algorithm achieves the best of both paradigms: optimal individual regret and constant communication costs.

Andrew Sellergren, Chufan Gao, Fereshteh Mahvar et al.

We introduce MedGemma 1.5 4B, the latest model in the MedGemma collection. MedGemma 1.5 expands on MedGemma 1 by integrating additional capabilities: high-dimensional medical imaging (CT/MRI volumes and histopathology whole slide images), anatomical localization via bounding boxes, multi-timepoint chest X-ray analysis, and improved medical document understanding (lab reports, electronic health records). We detail the innovations required to enable these modalities within a single architecture, including new training data, long-context 3D volume slicing, and whole-slide pathology sampling. Compared to MedGemma 1 4B, MedGemma 1.5 4B demonstrates significant gains in these new areas, improving 3D MRI condition classification accuracy by 11% and 3D CT condition classification by 3% (absolute improvements). In whole slide pathology imaging, MedGemma 1.5 4B achieves a 47% macro F1 gain. Additionally, it improves anatomical localization with a 35% increase in Intersection over Union on chest X-rays and achieves a 4% macro accuracy for longitudinal (multi-timepoint) chest x-ray analysis. Beyond its improved multimodal performance over MedGemma 1, MedGemma 1.5 improves on text-based clinical knowledge and reasoning, improving by 5% on MedQA accuracy and 22% on EHRQA accuracy. It also achieves an average of 18% macro F1 on 4 different lab report information extraction datasets (EHR Datasets 2, 3, 4, and Mendeley Clinical Laboratory Test Reports). Taken together, MedGemma 1.5 serves as a robust, open resource for the community, designed as an improved foundation on which developers can create the next generation of medical AI systems. Resources and tutorials for building upon MedGemma 1.5 can be found at https://goo.gle/MedGemma.

Zhuoyi Lu, Lin Yang, Sri Harsha Turlapati et al.

Robotics manipulation usually assumes that the shape and pose of the object are known to the robot prior to motion planning. However, precise geometric information is not always available in practice, and pose inference suffers from sensor uncertainties and view occlusion. In this work, we propose a unified model-based geometric framework integrating robotic haptic perception, modeling, and manipulation planning. Our novelties involve: \textit{i)} Introducing Bayesian Optimization (BO) to guide the haptic exploration for object shape inference, where superellipses are used to approximate geometric boundary; \textit{ii)} Adaptive formulation of manipulation potential encoding object geometry for quasi-static robot-object interaction; \textit{iii)} Proposing an online Ordinary Differential Equation (ODE) for real-time pose inference based on model prediction and tactile feedback. We deploy our system on a 2D robotic sorting task, and vary object geometries to validate the robustness and generalizability of our framework in both simulation and a real-world multi-arm setup.

Luyuan Xie, Yan Zhong, Lin Yang et al.

Convolution neural networks (CNNs) have good performance in low-complexity classification tasks such as acoustic scene classifications (ASCs). However, there are few studies on the relationship between the length of target speech and the size of the convolution kernels. In this paper, we combine Selective Kernel Network with Temporal-Convolution (TC-SKNet) to adjust the receptive field of convolution kernels to solve the problem of variable length of target voice while keeping low-complexity. GridMask is a data augmentation strategy by masking part of the raw data or feature area. It can enhance the generalization of the model as the role of dropout. In our experiments, the performance gain brought by GridMask is stronger than spectrum augmentation in ASCs. Finally, we adopt AutoML to search best structure of TC-SKNet and hyperparameters of GridMask for improving the classification performance. As a result, a peak accuracy of 59.87% TC-SKNet is equivalent to that of SOTA, but the parameters only use 20.9 K.

Xianqi He, Lin Yang, Chao Lu et al.

In urban environments, the complex and uncertain intersection scenarios are challenging for autonomous driving. To ensure safety, it is crucial to develop an adaptive decision making system that can handle the interaction with other vehicles. Manually designed model-based methods are reliable in common scenarios. But in uncertain environments, they are not reliable, so learning-based methods are proposed, especially reinforcement learning (RL) methods. However, current RL methods need retraining when the scenarios change. In other words, current RL methods cannot reuse accumulated knowledge. They forget learned knowledge when new scenarios are given. To solve this problem, we propose a hierarchical framework that can autonomously accumulate and reuse knowledge. The proposed method combines the idea of motion primitives (MPs) with hierarchical reinforcement learning (HRL). It decomposes complex problems into multiple basic subtasks to reduce the difficulty. The proposed method and other baseline methods are tested in a challenging intersection scenario based on the CARLA simulator. The intersection scenario contains three different subtasks that can reflect the complexity and uncertainty of real traffic flow. After offline learning and testing, the proposed method is proved to have the best performance among all methods.

Ningyuan Huang, Soledad Villar, Carey E. Priebe et al.

Graph Neural Networks (GNNs) are powerful deep learning methods for Non-Euclidean data. Popular GNNs are message-passing algorithms (MPNNs) that aggregate and combine signals in a local graph neighborhood. However, shallow MPNNs tend to miss long-range signals and perform poorly on some heterophilous graphs, while deep MPNNs can suffer from issues like over-smoothing or over-squashing. To mitigate such issues, existing works typically borrow normalization techniques from training neural networks on Euclidean data or modify the graph structures. Yet these approaches are not well-understood theoretically and could increase the overall computational complexity. In this work, we draw inspirations from spectral graph embedding and propose $\texttt{PowerEmbed}$ -- a simple layer-wise normalization technique to boost MPNNs. We show $\texttt{PowerEmbed}$ can provably express the top-$k$ leading eigenvectors of the graph operator, which prevents over-smoothing and is agnostic to the graph topology; meanwhile, it produces a list of representations ranging from local features to global signals, which avoids over-squashing. We apply $\texttt{PowerEmbed}$ in a wide range of simulated and real graphs and demonstrate its competitive performance, particularly for heterophilous graphs.

Lin Yang, Junjie Chen, Shutao Gao et al.

The rapid growth of deep learning (DL) has spurred interest in enhancing log-based anomaly detection. This approach aims to extract meaning from log events (log message templates) and develop advanced DL models for anomaly detection. However, these DL methods face challenges like heavy reliance on training data, labels, and computational resources due to model complexity. In contrast, traditional machine learning and data mining techniques are less data-dependent and more efficient but less effective than DL. To make log-based anomaly detection more practical, the goal is to enhance traditional techniques to match DL's effectiveness. Previous research in a different domain (linking questions on Stack Overflow) suggests that optimized traditional techniques can rival state-of-the-art DL methods. Drawing inspiration from this concept, we conducted an empirical study. We optimized the unsupervised PCA (Principal Component Analysis), a traditional technique, by incorporating lightweight semantic-based log representation. This addresses the issue of unseen log events in training data, enhancing log representation. Our study compared seven log-based anomaly detection methods, including four DL-based, two traditional, and the optimized PCA technique, using public and industrial datasets. Results indicate that the optimized unsupervised PCA technique achieves similar effectiveness to advanced supervised/semi-supervised DL methods while being more stable with limited training data and resource-efficient. This demonstrates the adaptability and strength of traditional techniques through small yet impactful adaptations.

Chaitanya Bhave, Pierre-Clément A. Simon, Casey Icenhour et al.

The widespread adoption of AI-assisted development in scientific software is not a future concern -- it is a present reality. Researchers are already using large language models to write code, generate test cases, and draft documentation, yet this practice remains largely unacknowledged and unguided in formal workflows and published work. This ad hoc, ungoverned use of AI represents a systemic risk to scientific software quality, particularly in safety-relevant modeling and simulation tools subject to strict Software Quality Assurance (SQA), or even Nuclear Quality Assurance Level 1 (NQA-1) standards, for which traceability, independent verification, and documented procedures are paramount. The question facing the scientific software community is, therefore, not whether to permit AI-assisted development, but how to govern it responsibly. This paper proposes guidance for AI-assisted code development in the context of strict software quality assurance. Using TMAP8 -- an open-source tritium migration code for fusion energy -- as a demonstration platform, we propose a structured framework for AI-assisted verification and validation (V&V) case development. V&V case development represents the ideal proving ground for establishing that governance: because validation cases have known solutions, correctness is objectively measurable, errors are identifiable by design, and the artifacts are fully auditable. The proposed guidance, developed based on practical experience described herein, operates within NQA-1 requirements, preserves human accountability, and establishes the disclosure and review standards that responsible AI-assisted scientific software development demands.

Lin Yang, Shuihua Wang, Yudong Zhang

Coronavirus disease 2019 (COVID-19) has spread all over the world for three years, but medical facilities in many areas still aren't adequate. There is a need for rapid COVID-19 diagnosis to identify high-risk patients and maximize the use of limited medical resources. Motivated by this fact, we proposed the deep learning framework MEDNC for automatic prediction and diagnosis of COVID-19 using computed tomography (CT) images. Our model was trained using two publicly available sets of COVID-19 data. And it was built with the inspiration of transfer learning. Results indicated that the MEDNC greatly enhanced the detection of COVID-19 infections, reaching an accuracy of 98.79% and 99.82% respectively. We tested MEDNC on a brain tumor and a blood cell dataset to show that our model applies to a wide range of problems. The outcomes demonstrated that our proposed models attained an accuracy of 99.39% and 99.28%, respectively. This COVID-19 recognition tool could help optimize healthcare resources and reduce clinicians' workload when screening for the virus.

Qi Song, Honglin Li, Yingchen Yu et al.

Recent releases such as o3 highlight human-like "thinking with images" reasoning that combines structured tool use with stepwise verification, yet most open-source approaches still rely on text-only chains, rigid visual schemas, or single-step pipelines, limiting flexibility, interpretability, and transferability on complex tasks. We introduce CodeDance, which explores executable code as a general solver for visual reasoning. Unlike fixed-schema calls (e.g., only predicting bounding-box coordinates), CodeDance defines, composes, and executes code to orchestrate multiple tools, compute intermediate results, and render visual artifacts (e.g., boxes, lines, plots) that support transparent, self-checkable reasoning. To guide this process, we introduce a reward for balanced and adaptive tool-call, which balances exploration with efficiency and mitigates tool overuse. Interestingly, beyond the expected capabilities taught by atomic supervision, we empirically observe novel emergent behaviors during RL training: CodeDance demonstrates novel tool invocations, unseen compositions, and cross-task transfer. These behaviors arise without task-specific fine-tuning, suggesting a general and scalable mechanism of executable visual reasoning. Extensive experiments across reasoning benchmarks (e.g., visual search, math, chart QA) show that CodeDance not only consistently outperforms schema-driven and text-only baselines, but also surpasses advanced closed models such as GPT-4o and larger open-source models.

Jingxiong Li, Sunyi Zheng, Zhongyi Shui et al.

Karyotyping is of importance for detecting chromosomal aberrations in human disease. However, chromosomes easily appear curved in microscopic images, which prevents cytogeneticists from analyzing chromosome types. To address this issue, we propose a framework for chromosome straightening, which comprises a preliminary processing algorithm and a generative model called masked conditional variational autoencoders (MC-VAE). The processing method utilizes patch rearrangement to address the difficulty in erasing low degrees of curvature, providing reasonable preliminary results for the MC-VAE. The MC-VAE further straightens the results by leveraging chromosome patches conditioned on their curvatures to learn the mapping between banding patterns and conditions. During model training, we apply a masking strategy with a high masking ratio to train the MC-VAE with eliminated redundancy. This yields a non-trivial reconstruction task, allowing the model to effectively preserve chromosome banding patterns and structure details in the reconstructed results. Extensive experiments on three public datasets with two stain styles show that our framework surpasses the performance of state-of-the-art methods in retaining banding patterns and structure details. Compared to using real-world bent chromosomes, the use of high-quality straightened chromosomes generated by our proposed method can improve the performance of various deep learning models for chromosome classification by a large margin. Such a straightening approach has the potential to be combined with other karyotyping systems to assist cytogeneticists in chromosome analysis.

Pingyi Chen, Honglin Li, Chenglu Zhu et al.

Whole slide images are the foundation of digital pathology for the diagnosis and treatment of carcinomas. Writing pathology reports is laborious and error-prone for inexperienced pathologists. To reduce the workload and improve clinical automation, we investigate how to generate pathology reports given whole slide images. On the data end, we curated the largest WSI-text dataset (PathText). In specific, we collected nearly 10000 high-quality WSI-text pairs for visual-language models by recognizing and cleaning pathology reports which narrate diagnostic slides in TCGA. On the model end, we propose the multiple instance generative model (MI-Gen) which can produce pathology reports for gigapixel WSIs. We benchmark our model on the largest subset of TCGA-PathoText. Experimental results show our model can generate pathology reports which contain multiple clinical clues and achieve competitive performance on certain slide-level tasks. We observe that simple semantic extraction from the pathology reports can achieve the best performance (0.838 of F1 score) on BRCA subtyping surpassing previous state-of-the-art approaches. Our collected dataset and related code are available.

Zhongyi Shui, Shichuan Zhang, Chenglu Zhu et al.

Reliable quantitative analysis of immunohistochemical staining images requires accurate and robust cell detection and classification. Recent weakly-supervised methods usually estimate probability density maps for cell recognition. However, in dense cell scenarios, their performance can be limited by pre- and post-processing as it is impossible to find a universal parameter setting. In this paper, we introduce an end-to-end framework that applies direct regression and classification for preset anchor points. Specifically, we propose a pyramidal feature aggregation strategy to combine low-level features and high-level semantics simultaneously, which provides accurate cell recognition for our purely point-based model. In addition, an optimized cost function is designed to adapt our multi-task learning framework by matching ground truth and predicted points. The experimental results demonstrate the superior accuracy and efficiency of the proposed method, which reveals the high potentiality in assisting pathologist assessments.

Chengyu Song, Linru Ma, Jianming Zheng et al.

Log-based insider threat detection (ITD) detects malicious user activities by auditing log entries. Recently, large language models (LLMs) with strong common sense knowledge have emerged in the domain of ITD. Nevertheless, diverse activity types and overlong log files pose a significant challenge for LLMs in directly discerning malicious ones within myriads of normal activities. Furthermore, the faithfulness hallucination issue from LLMs aggravates its application difficulty in ITD, as the generated conclusion may not align with user commands and activity context. In response to these challenges, we introduce Audit-LLM, a multi-agent log-based insider threat detection framework comprising three collaborative agents: (i) the Decomposer agent, breaking down the complex ITD task into manageable sub-tasks using Chain-of-Thought (COT) reasoning;(ii) the Tool Builder agent, creating reusable tools for sub-tasks to overcome context length limitations in LLMs; and (iii) the Executor agent, generating the final detection conclusion by invoking constructed tools. To enhance conclusion accuracy, we propose a pair-wise Evidence-based Multi-agent Debate (EMAD) mechanism, where two independent Executors iteratively refine their conclusions through reasoning exchange to reach a consensus. Comprehensive experiments conducted on three publicly available ITD datasets-CERT r4.2, CERT r5.2, and PicoDomain-demonstrate the superiority of our method over existing baselines and show that the proposed EMAD significantly improves the faithfulness of explanations generated by LLMs.

Pingyi Chen, Chenglu Zhu, Zhongyi Shui et al.

The success of supervised deep learning models on cell recognition tasks relies on detailed annotations. Many previous works have managed to reduce the dependency on labels. However, considering the large number of cells contained in a patch, costly and inefficient labeling is still inevitable. To this end, we explored label-free methods for cell recognition. Prior self-activation maps (PSM) are proposed to generate pseudo masks as training targets. To be specific, an activation network is trained with self-supervised learning. The gradient information in the shallow layers of the network is aggregated to generate prior self-activation maps. Afterward, a semantic clustering module is then introduced as a pipeline to transform PSMs to pixel-level semantic pseudo masks for downstream tasks. We evaluated our method on two histological datasets: MoNuSeg (cell segmentation) and BCData (multi-class cell detection). Compared with other fully-supervised and weakly-supervised methods, our method can achieve competitive performance without any manual annotations. Our simple but effective framework can also achieve multi-class cell detection which can not be done by existing unsupervised methods. The results show the potential of PSMs that might inspire other research to deal with the hunger for labels in medical area.

Honglin Li, Yunlong Zhang, Chenglu Zhu et al.

Histopathology image analysis is the golden standard of clinical diagnosis for Cancers. In doctors daily routine and computer-aided diagnosis, the Whole Slide Image (WSI) of histopathology tissue is used for analysis. Because of the extremely large scale of resolution, previous methods generally divide the WSI into a large number of patches, then aggregate all patches within a WSI by Multi-Instance Learning (MIL) to make the slide-level prediction when developing computer-aided diagnosis tools. However, most previous WSI-MIL models using global-attention without pairwise interaction and any positional information, or self-attention with absolute position embedding can not well handle shape varying large WSIs, e.g. testing WSIs after model deployment may be larger than training WSIs, since the model development set is always limited due to the difficulty of histopathology WSIs collection. To deal with the problem, in this paper, we propose to amend position embedding for shape varying long-contextual WSI by introducing Linear Bias into Attention, and adapt it from 1-d long sequence into 2-d long-contextual WSI which helps model extrapolate position embedding to unseen or under-fitted positions. We further utilize Flash-Attention module to tackle the computational complexity of Transformer, which also keep full self-attention performance compared to previous attention approximation work. Our method, Long-contextual MIL (Long-MIL) are evaluated on extensive experiments including 4 dataset including WSI classification and survival prediction tasks to validate the superiority on shape varying WSIs. The source code will be open-accessed soon.

Yuxin Kang, Hansheng Li, Xuan Zhao et al.

While achieving remarkable success for medical image segmentation, deep convolution neural networks (DCNNs) often fail to maintain their robustness when confronting test data with the novel distribution. To address such a drawback, the inductive bias of DCNNs is recently well-recognized. Specifically, DCNNs exhibit an inductive bias towards image style (e.g., superficial texture) rather than invariant content (e.g., object shapes). In this paper, we propose a method, named Invariant Content Synergistic Learning (ICSL), to improve the generalization ability of DCNNs on unseen datasets by controlling the inductive bias. First, ICSL mixes the style of training instances to perturb the training distribution. That is to say, more diverse domains or styles would be made available for training DCNNs. Based on the perturbed distribution, we carefully design a dual-branches invariant content synergistic learning strategy to prevent style-biased predictions and focus more on the invariant content. Extensive experimental results on two typical medical image segmentation tasks show that our approach performs better than state-of-the-art domain generalization methods.

Zhenwei Zhu, Liying Yang, Xuxin Lin et al.

Deep learning technology has made great progress in multi-view 3D reconstruction tasks. At present, most mainstream solutions establish the mapping between views and shape of an object by assembling the networks of 2D encoder and 3D decoder as the basic structure while they adopt different approaches to obtain aggregation of features from several views. Among them, the methods using attention-based fusion perform better and more stable than the others, however, they still have an obvious shortcoming -- the strong independence of each view during predicting the weights for merging leads to a lack of adaption of the global state. In this paper, we propose a global-aware attention-based fusion approach that builds the correlation between each branch and the global to provide a comprehensive foundation for weights inference. In order to enhance the ability of the network, we introduce a novel loss function to supervise the shape overall and propose a dynamic two-stage training strategy that can effectively adapt to all reconstructors with attention-based fusion. Experiments on ShapeNet verify that our method outperforms existing SOTA methods while the amount of parameters is far less than the same type of algorithm, Pix2Vox++. Furthermore, we propose a view-reduction method based on maximizing diversity and discuss the cost-performance tradeoff of our model to achieve a better performance when facing heavy input amount and limited computational cost.

Honglin Li, Yusuan Sun, Chenglu Zhu et al.

Cervical Cancer continues to be the leading gynecological malignancy, posing a persistent threat to women's health on a global scale. Early screening via cytology Whole Slide Image (WSI) diagnosis is critical to prevent this Cancer progression and improve survival rate, but pathologist's single test suffers inevitable false negative due to the immense number of cells that need to be reviewed within a WSI. Though computer-aided automated diagnostic models can serve as strong complement for pathologists, their effectiveness is hampered by the paucity of extensive and detailed annotations, coupled with the limited interpretability and robustness. These factors significantly hinder their practical applicability and reliability in clinical settings. To tackle these challenges, we develop an AI approach, which is a Scalable Technology for Robust and Interpretable Diagnosis built on Extensive data (STRIDE) of cervical cytology. STRIDE addresses the bottleneck of limited annotations by integrating patient-level labels with a small portion of cell-level labels through an end-to-end training strategy, facilitating scalable learning across extensive datasets. To further improve the robustness to real-world domain shifts of cytology slide-making and imaging, STRIDE employs color adversarial samples training that mimic staining and imaging variations. Lastly, to achieve pathologist-level interpretability for the trustworthiness in clinical settings, STRIDE can generate explanatory textual descriptions that simulates pathologists' diagnostic processes by cell image feature and textual description alignment. Conducting extensive experiments and evaluations in 183 medical centers with a dataset of 341,889 WSIs and 0.1 billion cells from cervical cytology patients, STRIDE has demonstrated a remarkable superiority over previous state-of-the-art techniques.

Sunyi Zheng, Jingxiong Li, Zhongyi Shui et al.

Karyotyping is an important procedure to assess the possible existence of chromosomal abnormalities. However, because of the non-rigid nature, chromosomes are usually heavily curved in microscopic images and such deformed shapes hinder the chromosome analysis for cytogeneticists. In this paper, we present a self-attention guided framework to erase the curvature of chromosomes. The proposed framework extracts spatial information and local textures to preserve banding patterns in a regression module. With complementary information from the bent chromosome, a refinement module is designed to further improve fine details. In addition, we propose two dedicated geometric constraints to maintain the length and restore the distortion of chromosomes. To train our framework, we create a synthetic dataset where curved chromosomes are generated from the real-world straight chromosomes by grid-deformation. Quantitative and qualitative experiments are conducted on synthetic and real-world data. Experimental results show that our proposed method can effectively straighten bent chromosomes while keeping banding details and length.

Kenzhi Iskandar Wong, Lin Yang, Qian Ying Lee et al.

Industrial robotic object handling often involves boxes and packages whose mass and center of mass are not known in advance. These uncertainties affect the force--moment balance required for stable lifting, and improper regulation of contact wrenches can lead to slip, object drop, orientation deviation, or excessive squeezing. This paper presents a friction-aware dual-arm box-handling framework for objects with unknown inertial properties. The proposed approach estimates the object mass and center of mass online from measured contact wrenches, and computes friction-feasible contact forces and torsional moments through a second-order cone program (SOCP) under ellipsoidal friction-limit-surface constraints. An offline trajectory refinement stage is also included to reduce undesired object--environment contact when geometric constraints are present. By enforcing friction feasibility as a hard constraint and minimizing contact effort within the feasible region, the framework achieves stable lifting without treating slip avoidance and excessive squeezing as separately tuned objectives. Experiments on a real dual-arm robotic system under different center-of-mass configurations demonstrate that the method lifts objects with unknown inertial properties while maintaining stable frictional contact.

Yuxuan Sun, Hao Wu, Chenglu Zhu et al.

The emergence of large multimodal models has unlocked remarkable potential in AI, particularly in pathology. However, the lack of specialized, high-quality benchmark impeded their development and precise evaluation. To address this, we introduce PathMMU, the largest and highest-quality expert-validated pathology benchmark for Large Multimodal Models (LMMs). It comprises 33,428 multimodal multi-choice questions and 24,067 images from various sources, each accompanied by an explanation for the correct answer. The construction of PathMMU harnesses GPT-4V's advanced capabilities, utilizing over 30,000 image-caption pairs to enrich captions and generate corresponding Q&As in a cascading process. Significantly, to maximize PathMMU's authority, we invite seven pathologists to scrutinize each question under strict standards in PathMMU's validation and test sets, while simultaneously setting an expert-level performance benchmark for PathMMU. We conduct extensive evaluations, including zero-shot assessments of 14 open-sourced and 4 closed-sourced LMMs and their robustness to image corruption. We also fine-tune representative LMMs to assess their adaptability to PathMMU. The empirical findings indicate that advanced LMMs struggle with the challenging PathMMU benchmark, with the top-performing LMM, GPT-4V, achieving only a 49.8% zero-shot performance, significantly lower than the 71.8% demonstrated by human pathologists. After fine-tuning, significantly smaller open-sourced LMMs can outperform GPT-4V but still fall short of the expertise shown by pathologists. We hope that the PathMMU will offer valuable insights and foster the development of more specialized, next-generation LMMs for pathology.

Honglin Li, Yunlong Zhang, Pingyi Chen et al.

Histopathology Whole Slide Image (WSI) analysis serves as the gold standard for clinical cancer diagnosis in the daily routines of doctors. To develop computer-aided diagnosis model for WSIs, previous methods typically employ Multi-Instance Learning to enable slide-level prediction given only slide-level labels. Among these models, vanilla attention mechanisms without pairwise interactions have traditionally been employed but are unable to model contextual information. More recently, self-attention models have been utilized to address this issue. To alleviate the computational complexity of long sequences in large WSIs, methods like HIPT use region-slicing, and TransMIL employs approximation of full self-attention. Both approaches suffer from suboptimal performance due to the loss of key information. Moreover, their use of absolute positional embedding struggles to effectively handle long contextual dependencies in shape-varying WSIs. In this paper, we first analyze how the low-rank nature of the long-sequence attention matrix constrains the representation ability of WSI modelling. Then, we demonstrate that the rank of attention matrix can be improved by focusing on local interactions via a local attention mask. Our analysis shows that the local mask aligns with the attention patterns in the lower layers of the Transformer. Furthermore, the local attention mask can be implemented during chunked attention calculation, reducing the quadratic computational complexity to linear with a small local bandwidth. Building on this, we propose a local-global hybrid Transformer for both computational acceleration and local-global information interactions modelling. Our method, Long-contextual MIL (LongMIL), is evaluated through extensive experiments on various WSI tasks to validate its superiority. Our code will be available at github.com/invoker-LL/Long-MIL.

Min Gan, Guang-Yong Chen, Yang Yi et al.

The proliferation of saddle points, rather than poor local minima, is increasingly understood to be a primary obstacle in large-scale non-convex optimization for machine learning. Variable elimination algorithms, like Variable Projection (VarPro), have long been observed to exhibit superior convergence and robustness in practice, yet a principled understanding of why they so effectively navigate these complex energy landscapes has remained elusive. In this work, we provide a rigorous geometric explanation by comparing the optimization landscapes of the original and reduced formulations. Through a rigorous analysis based on Hessian inertia and the Schur complement, we prove that variable elimination fundamentally reshapes the critical point structure of the objective function, revealing that local maxima in the reduced landscape are created from, and correspond directly to, saddle points in the original formulation. Our findings are illustrated on the canonical problem of non-convex matrix factorization, visualized directly on two-parameter neural networks, and finally validated in training deep Residual Networks, where our approach yields dramatic improvements in stability and convergence to superior minima. This work goes beyond explaining an existing method; it establishes landscape simplification via saddle point transformation as a powerful principle that can guide the design of a new generation of more robust and efficient optimization algorithms.

Chao Yi, Dian Chen, Gaoyang Guo et al.

Large language models (LLMs) have demonstrated remarkable potential in transforming recommender systems from implicit behavioral pattern matching to explicit intent reasoning. While RecGPT-V1 successfully pioneered this paradigm by integrating LLM-based reasoning into user interest mining and item tag prediction, it suffers from four fundamental limitations: (1) computational inefficiency and cognitive redundancy across multiple reasoning routes; (2) insufficient explanation diversity in fixed-template generation; (3) limited generalization under supervised learning paradigms; and (4) simplistic outcome-focused evaluation that fails to match human standards. To address these challenges, we present RecGPT-V2 with four key innovations. First, a Hierarchical Multi-Agent System restructures intent reasoning through coordinated collaboration, eliminating cognitive duplication while enabling diverse intent coverage. Combined with Hybrid Representation Inference that compresses user-behavior contexts, our framework reduces GPU consumption by 60% and improves exclusive recall from 9.39% to 10.99%. Second, a Meta-Prompting framework dynamically generates contextually adaptive prompts, improving explanation diversity by +7.3%. Third, constrained reinforcement learning mitigates multi-reward conflicts, achieving +24.1% improvement in tag prediction and +13.0% in explanation acceptance. Fourth, an Agent-as-a-Judge framework decomposes assessment into multi-step reasoning, improving human preference alignment. Online A/B tests on Taobao demonstrate significant improvements: +2.98% CTR, +3.71% IPV, +2.19% TV, and +11.46% NER. RecGPT-V2 establishes both the technical feasibility and commercial viability of deploying LLM-powered intent reasoning at scale, bridging the gap between cognitive exploration and industrial utility.

Lin Yang, Junlong Lyu, Wenlong Lyu et al.

Bayesian Optimization (BO) is a sample-efficient optimization algorithm widely employed across various applications. In some challenging BO tasks, input uncertainty arises due to the inevitable randomness in the optimization process, such as machining errors, execution noise, or contextual variability. This uncertainty deviates the input from the intended value before evaluation, resulting in significant performance fluctuations in the final result. In this paper, we introduce a novel robust Bayesian Optimization algorithm, AIRBO, which can effectively identify a robust optimum that performs consistently well under arbitrary input uncertainty. Our method directly models the uncertain inputs of arbitrary distributions by empowering the Gaussian Process with the Maximum Mean Discrepancy (MMD) and further accelerates the posterior inference via Nystrom approximation. Rigorous theoretical regret bound is established under MMD estimation error and extensive experiments on synthetic functions and real problems demonstrate that our approach can handle various input uncertainties and achieve state-of-the-art performance.

Dongqi Fu, Kaushik Rangadurai, Haiyu Lu et al.

The increase in data volume, computational resources, and model parameters during training has led to the development of numerous large-scale industrial retrieval models for recommendation tasks. However, effectively and efficiently deploying these large-scale foundational retrieval models remains a critical challenge that has not been fully addressed. Common quick-win solutions for deploying these massive models include relying on offline computations (such as cached user dictionaries) or distilling large models into smaller ones. Yet, both approaches fall short of fully leveraging the representational and inference capabilities of foundational models. In this paper, we explore whether it is possible to learn a hierarchical organization over the memory of foundational retrieval models. Such a hierarchical structure would enable more efficient search by reducing retrieval costs while preserving exactness. To achieve this, we propose jointly learning a hierarchical index using cross-attention and residual quantization for large-scale retrieval models. We also present its real-world deployment at Meta, supporting daily advertisement recommendations for billions of Facebook and Instagram users. Interestingly, we discovered that the intermediate nodes in the learned index correspond to a small set of high-quality data. Fine-tuning the model on this set further improves inference performance, and concretize the concept of "test-time training" within the recommendation system domain. We demonstrate these findings using both internal and public datasets with strong baseline comparisons and hope they contribute to the community's efforts in developing the next generation of foundational retrieval models.

Gheorghe Comanici, Eric Bieber, Mike Schaekermann et al. · amazon-science, baidu

In this report, we introduce the Gemini 2.X model family: Gemini 2.5 Pro and Gemini 2.5 Flash, as well as our earlier Gemini 2.0 Flash and Flash-Lite models. Gemini 2.5 Pro is our most capable model yet, achieving SoTA performance on frontier coding and reasoning benchmarks. In addition to its incredible coding and reasoning skills, Gemini 2.5 Pro is a thinking model that excels at multimodal understanding and it is now able to process up to 3 hours of video content. Its unique combination of long context, multimodal and reasoning capabilities can be combined to unlock new agentic workflows. Gemini 2.5 Flash provides excellent reasoning abilities at a fraction of the compute and latency requirements and Gemini 2.0 Flash and Flash-Lite provide high performance at low latency and cost. Taken together, the Gemini 2.X model generation spans the full Pareto frontier of model capability vs cost, allowing users to explore the boundaries of what is possible with complex agentic problem solving.

Baorong Shi, Bo Cui, Boyuan Jiang et al.

We present MedXIAOHE, a medical vision-language foundation model designed to advance general-purpose medical understanding and reasoning in real-world clinical applications. MedXIAOHE achieves state-of-the-art performance across diverse medical benchmarks and surpasses leading closed-source multimodal systems on multiple capabilities. To achieve this, we propose an entity-aware continual pretraining framework that organizes heterogeneous medical corpora to broaden knowledge coverage and reduce long-tail gaps (e.g., rare diseases). For medical expert-level reasoning and interaction, MedXIAOHE incorporates diverse medical reasoning patterns via reinforcement learning and tool-augmented agentic training, enabling multi-step diagnostic reasoning with verifiable decision traces. To improve reliability in real-world use, MedXIAOHE integrates user-preference rubrics, evidence-grounded reasoning, and low-hallucination long-form report generation, with improved adherence to medical instructions. We release this report to document our practical design choices, scaling insights, and evaluation framework, hoping to inspire further research.

Lin Yang, Anirvan Dutta, Yuan Ji et al.

Achieving human-level dexterity in contact-rich, tool-mediated manipulation remains a significant challenge due to visual occlusion and the underdetermined nature of haptic sensing. This paper introduces a parameterized Equilibrium Manifold (EM) as a unified representation for tool-mediated interaction, and develops a closed-loop framework that integrates haptic estimation, online planning, and adaptive stiffness control. We establish a physical-geometric duality using an adaptive manipulation potential incorporating a differentiable contact model, which induces the manifold's geometric structure and ensures that complex physical interactions are encapsulated as continuous operations on the EM. Within this framework, we reformulate haptic estimation as a manifold parameter estimation problem. Specifically, a hybrid inference strategy (haptic SLAM) is employed in which discrete object shapes are classified via particle filtering, while the continuous object pose is estimated using analytical gradients for efficient optimization. By continuously updating the parameters of the manipulation potential, the framework dynamically reshapes the induced EM to guide online trajectory replanning and implement uncertainty-aware impedance control, thereby closing the perception-action loop. The system is validated through simulation and over 260 real-world screw-loosening trials. Experimental results demonstrate robust identification and manipulation success in standard scenarios while maintaining accurate tracking. Furthermore, ablation studies confirm that haptic SLAM and uncertainty-aware stiffness modulation outperform fixed impedance baselines, effectively preventing jamming during tight tolerance interactions.

Jiacheng Guo, Suozhi Huang, Zixin Yao et al.

This paper introduces CryptoBench, the first expert-curated, dynamic benchmark designed to rigorously evaluate the real-world capabilities of Large Language Model (LLM) agents in the uniquely demanding and fast-paced cryptocurrency domain. Unlike general-purpose agent benchmarks for search and prediction, professional crypto analysis presents specific challenges: \emph{extreme time-sensitivity}, \emph{a highly adversarial information environment}, and the critical need to synthesize data from \emph{diverse, specialized sources}, such as on-chain intelligence platforms and real-time Decentralized Finance (DeFi) dashboards. CryptoBench thus serves as a much more challenging and valuable scenario for LLM agent assessment. To address these challenges, we constructed a live, dynamic benchmark featuring 50 questions per month, expertly designed by crypto-native professionals to mirror actual analyst workflows. These tasks are rigorously categorized within a four-quadrant system: Simple Retrieval, Complex Retrieval, Simple Prediction, and Complex Prediction. This granular categorization enables a precise assessment of an LLM agent's foundational data-gathering capabilities alongside its advanced analytical and forecasting skills. Our evaluation of ten LLMs, both directly and within an agentic framework, reveals a performance hierarchy and uncovers a failure mode. We observe a \textit{retrieval-prediction imbalance}, where many leading models, despite being proficient at data retrieval, demonstrate a pronounced weakness in tasks requiring predictive analysis. This highlights a problematic tendency for agents to appear factually grounded while lacking the deeper analytical capabilities to synthesize information.