Ziqi Xu

h-index9
2papers
379citations

2 Papers

7.7LGJul 6, 2023
Assisting Clinical Decisions for Scarcely Available Treatment via Disentangled Latent Representation

Bing Xue, Ahmed Sameh Said, Ziqi Xu et al.

Extracorporeal membrane oxygenation (ECMO) is an essential life-supporting modality for COVID-19 patients who are refractory to conventional therapies. However, the proper treatment decision has been the subject of significant debate and it remains controversial about who benefits from this scarcely available and technically complex treatment option. To support clinical decisions, it is a critical need to predict the treatment need and the potential treatment and no-treatment responses. Targeting this clinical challenge, we propose Treatment Variational AutoEncoder (TVAE), a novel approach for individualized treatment analysis. TVAE is specifically designed to address the modeling challenges like ECMO with strong treatment selection bias and scarce treatment cases. TVAE conceptualizes the treatment decision as a multi-scale problem. We model a patient's potential treatment assignment and the factual and counterfactual outcomes as part of their intrinsic characteristics that can be represented by a deep latent variable model. The factual and counterfactual prediction errors are alleviated via a reconstruction regularization scheme together with semi-supervision, and the selection bias and the scarcity of treatment cases are mitigated by the disentangled and distribution-matched latent space and the label-balancing generative strategy. We evaluate TVAE on two real-world COVID-19 datasets: an international dataset collected from 1651 hospitals across 63 countries, and a institutional dataset collected from 15 hospitals. The results show that TVAE outperforms state-of-the-art treatment effect models in predicting both the propensity scores and factual outcomes on heterogeneous COVID-19 datasets. Additional experiments also show TVAE outperforms the best existing models in individual treatment effect estimation on the synthesized IHDP benchmark dataset.

3.8CRJul 21, 2021
PoF: Proof-of-Following for Vehicle Platoons

Ziqi Xu, Jingcheng Li, Yanjun Pan et al.

Cooperative vehicle platooning significantly improves highway safety, fuel efficiency, and traffic flow. In this model, a set of vehicles move in line formation and coordinate acceleration, braking, and steering using a combination of physical sensing and vehicle-to-vehicle (V2V) messaging. The authenticity and integrity of the V2V messages are paramount to safety. For this reason, recent V2V and V2X standards support the integration of a PKI. However, a PKI cannot bind a vehicle's digital identity to the vehicle's physical state (location, velocity, etc.). As a result, a vehicle with valid cryptographic credentials can impact platoons from a remote location. In this paper, we seek to provide the missing link between the physical and the digital world in the context of vehicle platooning. We propose a new access control protocol we call Proof-of-Following (PoF) that verifies the following distance between a candidate and a verifier. The main idea is to draw security from the common, but constantly changing environment experienced by the closely traveling vehicles. We use the large-scale fading effect of ambient RF signals as a common source of randomness to construct a {\em PoF} primitive. The correlation of large-scale fading is an ideal candidate for the mobile outdoor environment because it exponentially decays with distance and time. We evaluate our PoF protocol on an experimental platoon of two vehicles in freeway, highway, and urban driving conditions. We demonstrate that the PoF withstands both the pre-recording and following attacks with overwhelming probability.