Xiaodi Li

Yuxi Xiao, Li Li, Xiaodi Li et al.

Two-view structure from motion (SfM) is the cornerstone of 3D reconstruction and visual SLAM (vSLAM). Many existing end-to-end learning-based methods usually formulate it as a brute regression problem. However, the inadequate utilization of traditional geometry model makes the model not robust in unseen environments. To improve the generalization capability and robustness of end-to-end two-view SfM network, we formulate the two-view SfM problem as a maximum likelihood estimation (MLE) and solve it with the proposed framework, denoted as DeepMLE. First, we propose to take the deep multi-scale correlation maps to depict the visual similarities of 2D image matches decided by ego-motion. In addition, in order to increase the robustness of our framework, we formulate the likelihood function of the correlations of 2D image matches as a Gaussian and Uniform mixture distribution which takes the uncertainty caused by illumination changes, image noise and moving objects into account. Meanwhile, an uncertainty prediction module is presented to predict the pixel-wise distribution parameters. Finally, we iteratively refine the depth and relative camera pose using the gradient-like information to maximize the likelihood function of the correlations. Extensive experimental results on several datasets prove that our method significantly outperforms the state-of-the-art end-to-end two-view SfM approaches in accuracy and generalization capability.

Haoyuan Shi, Tao Xu, Xiaodi Li et al.

Predicting the response of a cancer cell line to a therapeutic drug is pivotal for personalized medicine. Despite numerous deep learning methods that have been developed for drug response prediction, integrating diverse information about biological entities and predicting the directional response remain major challenges. Here, we propose a novel interpretable predictive model, DRExplainer, which leverages a directed graph convolutional network to enhance the prediction in a directed bipartite network framework. DRExplainer constructs a directed bipartite network integrating multi-omics profiles of cell lines, the chemical structure of drugs and known drug response to achieve directed prediction. Then, DRExplainer identifies the most relevant subgraph to each prediction in this directed bipartite network by learning a mask, facilitating critical medical decision-making. Additionally, we introduce a quantifiable method for model interpretability that leverages a ground truth benchmark dataset curated from biological features. In computational experiments, DRExplainer outperforms state-of-the-art predictive methods and another graph-based explanation method under the same experimental setting. Finally, the case studies further validate the interpretability and the effectiveness of DRExplainer in predictive novel drug response. Our code is available at: https://github.com/vshy-dream/DRExplainer.

Xiaodi Li, Jianfeng Gui, Qian Gao et al.

Graph Neural Networks have been widely applied in critical decision-making areas that demand interpretable predictions, leading to the flourishing development of interpretability algorithms. However, current graph interpretability algorithms tend to emphasize generality and often overlook biological significance, thereby limiting their applicability in predicting cancer drug responses. In this paper, we propose a novel post-hoc interpretability algorithm for cancer drug response prediction, CETExplainer, which incorporates a controllable edge-type-specific weighting mechanism. It considers the mutual information between subgraphs and predictions, proposing a structural scoring approach to provide fine-grained, biologically meaningful explanations for predictive models. We also introduce a method for constructing ground truth based on real-world datasets to quantitatively evaluate the proposed interpretability algorithm. Empirical analysis on the real-world dataset demonstrates that CETExplainer achieves superior stability and improves explanation quality compared to leading algorithms, thereby offering a robust and insightful tool for cancer drug prediction.

Xiaodi Li, Dingcheng Li, Rujun Gao et al.

Continual learning has become essential in many practical applications such as online news summaries and product classification. The primary challenge is known as catastrophic forgetting, a phenomenon where a model inadvertently discards previously learned knowledge when it is trained on new tasks. Existing solutions involve storing exemplars from previous classes, regularizing parameters during the fine-tuning process, or assigning different model parameters to each task. The proposed solution LSEBMCL (Latent Space Energy-Based Model for Continual Learning) in this work is to use energy-based models (EBMs) to prevent catastrophic forgetting by sampling data points from previous tasks when training on new ones. The EBM is a machine learning model that associates an energy value with each input data point. The proposed method uses an EBM layer as an outer-generator in the continual learning framework for NLP tasks. The study demonstrates the efficacy of EBM in NLP tasks, achieving state-of-the-art results in all experiments.