Wenxuan Wang

Wenxuan Wang, Jing Wang, Chen Chen et al.

The research community has witnessed the powerful potential of self-supervised Masked Image Modeling (MIM), which enables the models capable of learning visual representation from unlabeled data. In this paper, to incorporate both the crucial global structural information and local details for dense prediction tasks, we alter the perspective to the frequency domain and present a new MIM-based framework named FreMIM for self-supervised pre-training to better accomplish medical image segmentation tasks. Based on the observations that the detailed structural information mainly lies in the high-frequency components and the high-level semantics are abundant in the low-frequency counterparts, we further incorporate multi-stage supervision to guide the representation learning during the pre-training phase. Extensive experiments on three benchmark datasets show the superior advantage of our FreMIM over previous state-of-the-art MIM methods. Compared with various baselines trained from scratch, our FreMIM could consistently bring considerable improvements to model performance. The code will be publicly available at https://github.com/Rubics-Xuan/FreMIM.

Jing Wang, Jiangyun Li, Wei Li et al.

The contextual information is critical for various computer vision tasks, previous works commonly design plug-and-play modules and structural losses to effectively extract and aggregate the global context. These methods utilize fine-label to optimize the model but ignore that fine-trained features are also precious training resources, which can introduce preferable distribution to hard pixels (i.e., misclassified pixels). Inspired by contrastive learning in unsupervised paradigm, we apply the contrastive loss in a supervised manner and re-design the loss function to cast off the stereotype of unsupervised learning (e.g., imbalance of positives and negatives, confusion of anchors computing). To this end, we propose Positive-Negative Equal contrastive loss (PNE loss), which increases the latent impact of positive embedding on the anchor and treats the positive as well as negative sample pairs equally. The PNE loss can be directly plugged right into existing semantic segmentation frameworks and leads to excellent performance with neglectable extra computational costs. We utilize a number of classic segmentation methods (e.g., DeepLabV3, HRNetV2, OCRNet, UperNet) and backbone (e.g., ResNet, HRNet, Swin Transformer) to conduct comprehensive experiments and achieve state-of-the-art performance on three benchmark datasets (e.g., Cityscapes, COCO-Stuff and ADE20K). Our code will be publicly available soon.

Yichen Yan, Xingjian He, Wenxuan Wang et al.

Referring image segmentation (RIS) aims to segment an object mentioned in natural language from an image. The main challenge is text-to-pixel fine-grained correlation. In the previous methods, the final results are obtained by convolutions with a fixed kernel, which follows a similar pattern as traditional image segmentation. These methods lack explicit alignment of language and vision features in the segmentation stage, resulting in suboptimal correlation. In this paper, we introduce EAVL, a method explicitly aligning vision and language features. In contrast to fixed convolution kernels, we introduce a Vision-Language Aligner that aligns features in the segmentation stage using dynamic convolution kernels based on the input image and sentence. Specifically, we generate multiple queries representing different emphases of language expression. These queries are transformed into a series of query-based convolution kernels, which are applied in the segmentation stage to produce a series of masks. The final result is obtained by aggregating all masks. Our method harnesses the potential of the multi-modal features in the segmentation stage and aligns language features of different emphases with image features to achieve fine-grained text-to-pixel correlation. We surpass previous state-of-the-art methods on RefCOCO, RefCOCO+, and G-Ref by large margins. Additionally, our method is designed to be a generic plug-and-play module for cross-modality alignment in RIS task, making it easy to integrate with other RIS models for substantial performance improvements.

Wenxuan Wang, Chen Chen, Jing Wang et al.

For 3D medical image (e.g. CT and MRI) segmentation, the difficulty of segmenting each slice in a clinical case varies greatly. Previous research on volumetric medical image segmentation in a slice-by-slice manner conventionally use the identical 2D deep neural network to segment all the slices of the same case, ignoring the data heterogeneity among image slices. In this paper, we focus on multi-modal 3D MRI brain tumor segmentation and propose a dynamic architecture network named Med-DANet based on adaptive model selection to achieve effective accuracy and efficiency trade-off. For each slice of the input 3D MRI volume, our proposed method learns a slice-specific decision by the Decision Network to dynamically select a suitable model from the predefined Model Bank for the subsequent 2D segmentation task. Extensive experimental results on both BraTS 2019 and 2020 datasets show that our proposed method achieves comparable or better results than previous state-of-the-art methods for 3D MRI brain tumor segmentation with much less model complexity. Compared with the state-of-the-art 3D method TransBTS, the proposed framework improves the model efficiency by up to 3.5x without sacrificing the accuracy. Our code will be publicly available soon.

Xin Li, Kun Yuan, Yajing Pei et al.

This paper reviews the NTIRE 2024 Challenge on Shortform UGC Video Quality Assessment (S-UGC VQA), where various excellent solutions are submitted and evaluated on the collected dataset KVQ from popular short-form video platform, i.e., Kuaishou/Kwai Platform. The KVQ database is divided into three parts, including 2926 videos for training, 420 videos for validation, and 854 videos for testing. The purpose is to build new benchmarks and advance the development of S-UGC VQA. The competition had 200 participants and 13 teams submitted valid solutions for the final testing phase. The proposed solutions achieved state-of-the-art performances for S-UGC VQA. The project can be found at https://github.com/lixinustc/KVQChallenge-CVPR-NTIRE2024.

Wenxuan Wang, Tongtian Yue, Yisi Zhang et al.

Referring expression segmentation (RES) aims at segmenting the foreground masks of the entities that match the descriptive natural language expression. Previous datasets and methods for classic RES task heavily rely on the prior assumption that one expression must refer to object-level targets. In this paper, we take a step further to finer-grained part-level RES task. To promote the object-level RES task towards finer-grained vision-language understanding, we put forward a new multi-granularity referring expression segmentation (MRES) task and construct an evaluation benchmark called RefCOCOm by manual annotations. By employing our automatic model-assisted data engine, we build the largest visual grounding dataset namely MRES-32M, which comprises over 32.2M high-quality masks and captions on the provided 1M images. Besides, a simple yet strong model named UniRES is designed to accomplish the unified object-level and part-level grounding task. Extensive experiments on our RefCOCOm for MRES and three datasets (i.e., RefCOCO(+/g) for classic RES task demonstrate the superiority of our method over previous state-of-the-art methods. To foster future research into fine-grained visual grounding, our benchmark RefCOCOm, the MRES-32M dataset and model UniRES will be publicly available at https://github.com/Rubics-Xuan/MRES

Jiachen Shen, Wenxuan Wang, Chen Chen et al.

The "pre-training then fine-tuning (FT)" paradigm is widely adopted to boost the model performance of deep learning-based methods for medical volumetric segmentation. However, conventional full FT incurs high computational and memory costs. Thus, it is of increasing importance to fine-tune pre-trained models for medical volumetric segmentation tasks in a both effective and parameter-efficient manner. In this paper, we introduce a new framework named Med-Tuning to realize parameter-efficient tuning (PET) for medical volumetric segmentation task and an efficient plug-and-play module named Med-Adapter for task-specific feature extraction. With a small number of tuned parameters, our framework enhances the 2D baselines's precision on segmentation tasks, which are pre-trained on natural images. Extensive experiments on three benchmark datasets (CT and MRI modalities) show that our method achieves better results than previous PET methods on volumetric segmentation tasks. Compared to full FT, Med-Tuning reduces the fine-tuned model parameters by up to 4x, with even better segmentation performance. Our project webpage is at \url{https://rubics-xuan.github.io/Med-Tuning/}.

Haoran Shen, Yifu Zhang, Wenxuan Wang et al.

Recent works have shown that the computational efficiency of 3D medical image (e.g. CT and MRI) segmentation can be impressively improved by dynamic inference based on slice-wise complexity. As a pioneering work, a dynamic architecture network for medical volumetric segmentation (i.e. Med-DANet) has achieved a favorable accuracy and efficiency trade-off by dynamically selecting a suitable 2D candidate model from the pre-defined model bank for different slices. However, the issues of incomplete data analysis, high training costs, and the two-stage pipeline in Med-DANet require further improvement. To this end, this paper further explores a unified formulation of the dynamic inference framework from the perspective of both the data itself and the model structure. For each slice of the input volume, our proposed method dynamically selects an important foreground region for segmentation based on the policy generated by our Decision Network and Crop Position Network. Besides, we propose to insert a stage-wise quantization selector to the employed segmentation model (e.g. U-Net) for dynamic architecture adapting. Extensive experiments on BraTS 2019 and 2020 show that our method achieves comparable or better performance than previous state-of-the-art methods with much less model complexity. Compared with previous methods Med-DANet and TransBTS with dynamic and static architecture respectively, our framework improves the model efficiency by up to nearly 4.1 and 17.3 times with comparable segmentation results on BraTS 2019.

Jiangyun Li, Wenxuan Wang, Chen Chen et al.

Transformer, benefiting from global (long-range) information modeling using self-attention mechanism, has been successful in natural language processing and computer vision recently. Convolutional Neural Networks, capable of capturing local features, are difficult to model explicit long-distance dependencies from global feature space. However, both local and global features are crucial for dense prediction tasks, especially for 3D medical image segmentation. In this paper, we present the further attempt to exploit Transformer in 3D CNN for 3D medical image volumetric segmentation and propose a novel network named TransBTSV2 based on the encoder-decoder structure. Different from TransBTS, the proposed TransBTSV2 is not limited to brain tumor segmentation (BTS) but focuses on general medical image segmentation, providing a stronger and more efficient 3D baseline for volumetric segmentation of medical images. As a hybrid CNN-Transformer architecture, TransBTSV2 can achieve accurate segmentation of medical images without any pre-training, possessing the strong inductive bias as CNNs and powerful global context modeling ability as Transformer. With the proposed insight to redesign the internal structure of Transformer block and the introduced Deformable Bottleneck Module to capture shape-aware local details, a highly efficient architecture is achieved with superior performance. Extensive experimental results on four medical image datasets (BraTS 2019, BraTS 2020, LiTS 2017 and KiTS 2019) demonstrate that TransBTSV2 achieves comparable or better results compared to the state-of-the-art methods for the segmentation of brain tumor, liver tumor as well as kidney tumor. Code will be publicly available at https://github.com/Wenxuan-1119/TransBTS.

Wenxuan Wang, Chen Chen, Meng Ding et al.

Transformer, which can benefit from global (long-range) information modeling using self-attention mechanisms, has been successful in natural language processing and 2D image classification recently. However, both local and global features are crucial for dense prediction tasks, especially for 3D medical image segmentation. In this paper, we for the first time exploit Transformer in 3D CNN for MRI Brain Tumor Segmentation and propose a novel network named TransBTS based on the encoder-decoder structure. To capture the local 3D context information, the encoder first utilizes 3D CNN to extract the volumetric spatial feature maps. Meanwhile, the feature maps are reformed elaborately for tokens that are fed into Transformer for global feature modeling. The decoder leverages the features embedded by Transformer and performs progressive upsampling to predict the detailed segmentation map. Extensive experimental results on both BraTS 2019 and 2020 datasets show that TransBTS achieves comparable or higher results than previous state-of-the-art 3D methods for brain tumor segmentation on 3D MRI scans. The source code is available at https://github.com/Wenxuan-1119/TransBTS

Jie Liu, Wenxuan Wang, Yihang Su et al.

The significant breakthroughs of Medical Multi-Modal Large Language Models (Med-MLLMs) renovate modern healthcare with robust information synthesis and medical decision support. However, these models are often evaluated on benchmarks that are unsuitable for the Med-MLLMs due to the complexity of real-world diagnostics across diverse specialties. To address this gap, we introduce Asclepius, a novel Med-MLLM benchmark that comprehensively assesses Med-MLLMs in terms of: distinct medical specialties (cardiovascular, gastroenterology, etc.) and different diagnostic capacities (perception, disease analysis, etc.). Grounded in 3 proposed core principles, Asclepius ensures a comprehensive evaluation by encompassing 15 medical specialties, stratifying into 3 main categories and 8 sub-categories of clinical tasks, and exempting overlap with existing VQA dataset. We further provide an in-depth analysis of 6 Med-MLLMs and compare them with 3 human specialists, providing insights into their competencies and limitations in various medical contexts. Our work not only advances the understanding of Med-MLLMs' capabilities but also sets a precedent for future evaluations and the safe deployment of these models in clinical environments.

Wenxuan Wang, Fan Zhang, Yufeng Cui et al.

Existing vision tokenization isolates the optimization of vision tokenizers from downstream training, implicitly assuming the visual tokens can generalize well across various tasks, e.g., image generation and visual question answering. The vision tokenizer optimized for low-level reconstruction is agnostic to downstream tasks requiring varied representations and semantics. This decoupled paradigm introduces a critical misalignment: The loss of the vision tokenization can be the representation bottleneck for target tasks. For example, errors in tokenizing text in a given image lead to poor results when recognizing or generating them. To address this, we propose ETT, an end-to-end vision tokenizer tuning approach that enables joint optimization between vision tokenization and target autoregressive tasks. Unlike prior autoregressive models that use only discrete indices from a frozen vision tokenizer, ETT leverages the visual embeddings of the tokenizer codebook, and optimizes the vision tokenizers end-to-end with both reconstruction and caption objectives. ETT can be seamlessly integrated into existing training pipelines with minimal architecture modifications. Our ETT is simple to implement and integrate, without the need to adjust the original codebooks or architectures of the employed large language models. Extensive experiments demonstrate that our proposed end-to-end vision tokenizer tuning unlocks significant performance gains, i.e., 2-6% for multimodal understanding and visual generation tasks compared to frozen tokenizer baselines, while preserving the original reconstruction capability. We hope this very simple and strong method can empower multimodal foundation models besides image generation and understanding.

Liwen Wang, Wenxuan Wang, Shuai Wang et al.

The rapid advancement of Large Language Models (LLMs) has led to the emergence of Multi-Agent Systems (MAS) to perform complex tasks through collaboration. However, the intricate nature of MAS, including their architecture and agent interactions, raises significant concerns regarding intellectual property (IP) protection. In this paper, we introduce MASLEAK, a novel attack framework designed to extract sensitive information from MAS applications. MASLEAK targets a practical, black-box setting, where the adversary has no prior knowledge of the MAS architecture or agent configurations. The adversary can only interact with the MAS through its public API, submitting attack query $q$ and observing outputs from the final agent. Inspired by how computer worms propagate and infect vulnerable network hosts, MASLEAK carefully crafts adversarial query $q$ to elicit, propagate, and retain responses from each MAS agent that reveal a full set of proprietary components, including the number of agents, system topology, system prompts, task instructions, and tool usages. We construct the first synthetic dataset of MAS applications with 810 applications and also evaluate MASLEAK against real-world MAS applications, including Coze and CrewAI. MASLEAK achieves high accuracy in extracting MAS IP, with an average attack success rate of 87% for system prompts and task instructions, and 92% for system architecture in most cases. We conclude by discussing the implications of our findings and the potential defenses.

Jie Liu, Wenxuan Wang, Zizhan Ma et al.

Clinical decision making (CDM) is a complex, dynamic process crucial to healthcare delivery, yet it remains a significant challenge for artificial intelligence systems. While Large Language Model (LLM)-based agents have been tested on general medical knowledge using licensing exams and knowledge question-answering tasks, their performance in the CDM in real-world scenarios is limited due to the lack of comprehensive testing datasets that mirror actual medical practice. To address this gap, we present MedChain, a dataset of 12,163 clinical cases that covers five key stages of clinical workflow. MedChain distinguishes itself from existing benchmarks with three key features of real-world clinical practice: personalization, interactivity, and sequentiality. Further, to tackle real-world CDM challenges, we also propose MedChain-Agent, an AI system that integrates a feedback mechanism and a MCase-RAG module to learn from previous cases and adapt its responses. MedChain-Agent demonstrates remarkable adaptability in gathering information dynamically and handling sequential clinical tasks, significantly outperforming existing approaches.

Wenxuan Wang, Jing Liu, Xingjian He et al.

Referring image segmentation (RIS) is a fundamental vision-language task that intends to segment a desired object from an image based on a given natural language expression. Due to the essentially distinct data properties between image and text, most of existing methods either introduce complex designs towards fine-grained vision-language alignment or lack required dense alignment, resulting in scalability issues or mis-segmentation problems such as over- or under-segmentation. To achieve effective and efficient fine-grained feature alignment in the RIS task, we explore the potential of masked multimodal modeling coupled with self-distillation and propose a novel cross-modality masked self-distillation framework named CM-MaskSD, in which our method inherits the transferred knowledge of image-text semantic alignment from CLIP model to realize fine-grained patch-word feature alignment for better segmentation accuracy. Moreover, our CM-MaskSD framework can considerably boost model performance in a nearly parameter-free manner, since it shares weights between the main segmentation branch and the introduced masked self-distillation branches, and solely introduces negligible parameters for coordinating the multimodal features. Comprehensive experiments on three benchmark datasets (i.e. RefCOCO, RefCOCO+, G-Ref) for the RIS task convincingly demonstrate the superiority of our proposed framework over previous state-of-the-art methods.

Yanwei Fu, Feng Li, Wenxuan Wang et al.

The Coronavirus disease 2019 (COVID-19) has affected several million people. With the outbreak of the epidemic, many researchers are devoting themselves to the COVID-19 screening system. The standard practices for rapid risk screening of COVID-19 are the CT imaging or RT-PCR (real-time polymerase chain reaction). However, these methods demand professional efforts of the acquisition of CT images and saliva samples, a certain amount of waiting time, and most importantly prohibitive examination fee in some countries. Recently, some literatures have shown that the COVID-19 patients usually accompanied by ocular manifestations consistent with the conjunctivitis, including conjunctival hyperemia, chemosis, epiphora, or increased secretions. After more than four months study, we found that the confirmed cases of COVID-19 present the consistent ocular pathological symbols; and we propose a new screening method of analyzing the eye-region images, captured by common CCD and CMOS cameras, could reliably make a rapid risk screening of COVID-19 with very high accuracy. We believe a system implementing such an algorithm should assist the triage management or the clinical diagnosis. To further evaluate our algorithm and approved by the Ethics Committee of Shanghai public health clinic center of Fudan University, we conduct a study of analyzing the eye-region images of 303 patients (104 COVID-19, 131 pulmonary, and 68 ocular patients), as well as 136 healthy people. Remarkably, our results of COVID-19 patients in testing set consistently present similar ocular pathological symbols; and very high testing results have been achieved in terms of sensitivity and specificity. We hope this study can be inspiring and helpful for encouraging more researches in this topic.

Wenxuan Wang, Qiang Sun, Tao Chen et al.

The recent research of facial expression recognition has made a lot of progress due to the development of deep learning technologies, but some typical challenging problems such as the variety of rich facial expressions and poses are still not resolved. To solve these problems, we develop a new Facial Expression Recognition (FER) framework by involving the facial poses into our image synthesizing and classification process. There are two major novelties in this work. First, we create a new facial expression dataset of more than 200k images with 119 persons, 4 poses and 54 expressions. To our knowledge this is the first dataset to label faces with subtle emotion changes for expression recognition purpose. It is also the first dataset that is large enough to validate the FER task on unbalanced poses, expressions, and zero-shot subject IDs. Second, we propose a facial pose generative adversarial network (FaPE-GAN) to synthesize new facial expression images to augment the data set for training purpose, and then learn a LightCNN based Fa-Net model for expression classification. Finally, we advocate four novel learning tasks on this dataset. The experimental results well validate the effectiveness of the proposed approach.