Joonho Lee

Ruining Deng, Tianyuan Yao, Yucheng Tang et al.

Chronic kidney disease (CKD) is a major global health issue, affecting over 10% of the population and causing significant mortality. While kidney biopsy remains the gold standard for CKD diagnosis and treatment, the lack of comprehensive benchmarks for kidney pathology segmentation hinders progress in the field. To address this, we organized the Kidney Pathology Image Segmentation (KPIs) Challenge, introducing a dataset that incorporates preclinical rodent models of CKD with over 10,000 annotated glomeruli from 60+ Periodic Acid Schiff (PAS)-stained whole slide images. The challenge includes two tasks, patch-level segmentation and whole slide image segmentation and detection, evaluated using the Dice Similarity Coefficient (DSC) and F1-score. By encouraging innovative segmentation methods that adapt to diverse CKD models and tissue conditions, the KPIs Challenge aims to advance kidney pathology analysis, establish new benchmarks, and enable precise, large-scale quantification for disease research and diagnosis.

Kumar Shridhar, Joonho Lee, Hideaki Hayashi et al.

Activation functions play an important role in training artificial neural networks. The majority of currently used activation functions are deterministic in nature, with their fixed input-output relationship. In this work, we propose a novel probabilistic activation function, called ProbAct. ProbAct is decomposed into a mean and variance and the output value is sampled from the formed distribution, making ProbAct a stochastic activation function. The values of mean and variances can be fixed using known functions or trained for each element. In the trainable ProbAct, the mean and the variance of the activation distribution is trained within the back-propagation framework alongside other parameters. We show that the stochastic perturbation induced through ProbAct acts as a viable generalization technique for feature augmentation. In our experiments, we compare ProbAct with well-known activation functions on classification tasks on different modalities: Images(CIFAR-10, CIFAR-100, and STL-10) and Text (Large Movie Review). We show that ProbAct increases the classification accuracy by +2-3% compared to ReLU or other conventional activation functions on both original datasets and when datasets are reduced to 50% and 25% of the original size. Finally, we show that ProbAct learns an ensemble of models by itself that can be used to estimate the uncertainties associated with the prediction and provides robustness to noisy inputs.