Hanwen Liu

Zhenyu Bi, Sajib Acharjee Dip, Daniel Hajialigol et al.

The capabilities of AI for biomedicine span a wide spectrum, from the atomic level, where it solves partial differential equations for quantum systems, to the molecular level, predicting chemical or protein structures, and further extending to societal predictions like infectious disease outbreaks. Recent advancements in large language models, exemplified by models like ChatGPT, have showcased significant prowess in natural language tasks, such as translating languages, constructing chatbots, and answering questions. When we consider biomedical data, we observe a resemblance to natural language in terms of sequences: biomedical literature and health records presented as text, biological sequences or sequencing data arranged in sequences, or sensor data like brain signals as time series. The question arises: Can we harness the potential of recent large language models to drive biomedical knowledge discoveries? In this survey, we will explore the application of large language models to three crucial categories of biomedical data: 1) textual data, 2) biological sequences, and 3) brain signals. Furthermore, we will delve into large language model challenges in biomedical research, including ensuring trustworthiness, achieving personalization, and adapting to multi-modal data representation

Pablo Navarrete Michelini, Wenbin Chen, Hanwen Liu et al.

Multi-Grid Back-Projection (MGBP) is a fully-convolutional network architecture that can learn to restore images and videos with upscaling artifacts. Using the same strategy of multi-grid partial differential equation (PDE) solvers this multiscale architecture scales computational complexity efficiently with increasing output resolutions. The basic processing block is inspired in the iterative back-projection (IBP) algorithm and constitutes a type of cross-scale residual block with feedback from low resolution references. The architecture performs in par with state-of-the-arts alternatives for regression targets that aim to recover an exact copy of a high resolution image or video from which only a downscale image is known. A perceptual quality target aims to create more realistic outputs by introducing artificial changes that can be different from a high resolution original content as long as they are consistent with the low resolution input. For this target we propose a strategy using noise inputs in different resolution scales to control the amount of artificial details generated in the output. The noise input controls the amount of innovation that the network uses to create artificial realistic details. The effectiveness of this strategy is shown in benchmarks and it is explained as a particular strategy to traverse the perception-distortion plane.

Pablo Navarrete Michelini, Wenbin Chen, Hanwen Liu et al.

Here, we describe our solution for the AIM-2019 Extreme Super-Resolution Challenge, where we won the 1st place in terms of perceptual quality (MOS) similar to the ground truth and achieved the 5th place in terms of high-fidelity (PSNR). To tackle this challenge, we introduce the second generation of MultiGrid BackProjection networks (MGBPv2) whose major modifications make the system scalable and more general than its predecessor. It combines the scalability of the multigrid algorithm and the performance of iterative backprojections. In its original form, MGBP is limited to a small number of parameters due to a strongly recursive structure. In MGBPv2, we make full use of the multigrid recursion from the beginning of the network; we allow different parameters in every module of the network; we simplify the main modules; and finally, we allow adjustments of the number of network features based on the scale of operation. For inference tasks, we introduce an overlapping patch approach to further allow processing of very large images (e.g. 8K). Our training strategies make use of a multiscale loss, combining distortion and/or perception losses on the output as well as downscaled output images. The final system can balance between high quality and high performance.

Pablo Navarrete Michelini, Hanwen Liu, Yunhua Lu et al.

Convolutional networks are large linear systems divided into layers and connected by non-linear units. These units are the "articulations" that allow the network to adapt to the input. To understand how a network manages to solve a problem we must look at the articulated decisions in entirety. If we could capture the actions of non-linear units for a particular input, we would be able to replay the whole system back and forth as if it was always linear. It would also reveal the actions of non-linearities because the resulting linear system, a Linear Interpreter, depends on the input image. We introduce a hooking layer, called a LinearScope, which allows us to run the network and the linear interpreter in parallel. Its implementation is simple, flexible and efficient. From here we can make many curious inquiries: how do these linear systems look like? When the rows and columns of the transformation matrix are images, how do they look like? What type of basis do these linear transformations rely on? The answers depend on the problems presented, through which we take a tour to some popular architectures used for classification, super-resolution (SR) and image-to-image translation (I2I). For classification we observe that popular networks use a pixel-wise vote per class strategy and heavily rely on bias parameters. For SR and I2I we find that CNNs use wavelet-type basis similar to the human visual system. For I2I we reveal copy-move and template-creation strategies to generate outputs.

Andrey Ignatov, Radu Timofte, Thang Van Vu et al.

This paper reviews the first challenge on efficient perceptual image enhancement with the focus on deploying deep learning models on smartphones. The challenge consisted of two tracks. In the first one, participants were solving the classical image super-resolution problem with a bicubic downscaling factor of 4. The second track was aimed at real-world photo enhancement, and the goal was to map low-quality photos from the iPhone 3GS device to the same photos captured with a DSLR camera. The target metric used in this challenge combined the runtime, PSNR scores and solutions' perceptual results measured in the user study. To ensure the efficiency of the submitted models, we additionally measured their runtime and memory requirements on Android smartphones. The proposed solutions significantly improved baseline results defining the state-of-the-art for image enhancement on smartphones.

Pablo Navarrete Michelini, Dan Zhu, Hanwen Liu

We describe our solution for the PIRM Super-Resolution Challenge 2018 where we achieved the 2nd best perceptual quality for average RMSE<=16, 5th best for RMSE<=12.5, and 7th best for RMSE<=11.5. We modify a recently proposed Multi-Grid Back-Projection (MGBP) architecture to work as a generative system with an input parameter that can control the amount of artificial details in the output. We propose a discriminator for adversarial training with the following novel properties: it is multi-scale that resembles a progressive-GAN; it is recursive that balances the architecture of the generator; and it includes a new layer to capture significant statistics of natural images. Finally, we propose a training strategy that avoids conflicts between reconstruction and perceptual losses. Our configuration uses only 281k parameters and upscales each image of the competition in 0.2s in average.

Pablo Navarrete Michelini, Hanwen Liu, Dan Zhu

We introduce a novel deep-learning architecture for image upscaling by large factors (e.g. 4x, 8x) based on examples of pristine high-resolution images. Our target is to reconstruct high-resolution images from their downscale versions. The proposed system performs a multi-level progressive upscaling, starting from small factors (2x) and updating for higher factors (4x and 8x). The system is recursive as it repeats the same procedure at each level. It is also residual since we use the network to update the outputs of a classic upscaler. The network residuals are improved by Iterative Back-Projections (IBP) computed in the features of a convolutional network. To work in multiple levels we extend the standard back-projection algorithm using a recursion analogous to Multi-Grid algorithms commonly used as solvers of large systems of linear equations. We finally show how the network can be interpreted as a standard upsampling-and-filter upscaler with a space-variant filter that adapts to the geometry. This approach allows us to visualize how the network learns to upscale. Finally, our system reaches state of the art quality for models with relatively few number of parameters.

Pablo Navarrete Michelini, Hanwen Liu

We interpret convolutional networks as adaptive filters and combine them with so-called MuxOut layers to efficiently upscale low resolution images. We formalize this interpretation by deriving a linear and space-variant structure of a convolutional network when its activations are fixed. We introduce general purpose algorithms to analyze a network and show its overall filter effect for each given location. We use this analysis to evaluate two types of image upscalers: deterministic upscalers that target the recovery of details from original content; and second, a new generation of upscalers that can sample the distribution of upscale aliases (images that share the same downscale version) that look like real content.