Qingyun Wang

Yumeng Wang, Zhiyuan Fan, Qingyun Wang et al.

Large Language Models (LLMs) are pretrained on extensive multilingual corpora to acquire both language-specific cultural knowledge and general knowledge. Ideally, while LLMs should provide consistent responses to culture-independent questions across languages, we observe significant performance disparities. To address this, we explore the Cross-Lingual Self-Aligning ability of Language Models (CALM) to align knowledge across languages. Specifically, for a given question, we sample multiple responses across different languages and select the most self-consistent response as the target, leaving the remaining responses as negative examples. We then employ direct preference optimization (DPO) to align the model's knowledge across different languages. Evaluations on the MEDQA and X-CSQA datasets demonstrate CALM's effectiveness in enhancing cross-lingual knowledge question answering, both in zero-shot and retrieval-augmented settings. We also found that increasing the number of languages involved in CALM training leads to higher accuracy and consistency. We offer a qualitative analysis of how cross-lingual consistency can enhance knowledge alignment and explore the method's generalizability.

Minghao Liu, Zhitao He, Zhiyuan Fan et al.

Text-guided image editing has seen significant progress in natural image domains, but its application in medical imaging remains limited and lacks standardized evaluation frameworks. Such editing could revolutionize clinical practices by enabling personalized surgical planning, enhancing medical education, and improving patient communication. To bridge this gap, we introduce MedEBench1, a robust benchmark designed to diagnose reliability in text-guided medical image editing. MedEBench consists of 1,182 clinically curated image-prompt pairs covering 70 distinct editing tasks and 13 anatomical regions. It contributes in three key areas: (1) a clinically grounded evaluation framework that measures Editing Accuracy, Context Preservation, and Visual Quality, complemented by detailed descriptions of intended edits and corresponding Region-of-Interest (ROI) masks; (2) a comprehensive comparison of seven state-of-theart models, revealing consistent patterns of failure; and (3) a diagnostic error analysis technique that leverages attention alignment, using Intersection-over-Union (IoU) between model attention maps and ROI masks to identify mislocalization issues, where models erroneously focus on incorrect anatomical regions. MedEBench sets the stage for developing more reliable and clinically effective text-guided medical image editing tools.

Ruiling Xu, Yifan Zhang, Qingyun Wang et al.

Organic reaction mechanisms are the stepwise elementary reactions by which reactants form intermediates and products, and are fundamental to understanding chemical reactivity and designing new molecules and reactions. Although large language models (LLMs) have shown promise in understanding chemical tasks such as synthesis design, it is unclear to what extent this reflects genuine chemical reasoning capabilities, i.e., the ability to generate valid intermediates, maintain chemical consistency, and follow logically coherent multi-step pathways. We address this by introducing oMeBench, the first large-scale, expert-curated benchmark for organic mechanism reasoning in organic chemistry. It comprises over 10,000 annotated mechanistic steps with intermediates, type labels, and difficulty ratings. Furthermore, to evaluate LLM capability more precisely and enable fine-grained scoring, we propose oMeS, a dynamic evaluation framework that combines step-level logic and chemical similarity. We analyze the performance of state-of-the-art LLMs, and our results show that although current models display promising chemical intuition, they struggle with correct and consistent multi-step reasoning. Notably, we find that using prompting strategy and fine-tuning a specialist model on our proposed dataset increases performance by 50% over the leading closed-source model. We hope that oMeBench will serve as a rigorous foundation for advancing AI systems toward genuine chemical reasoning.