Qianwen Zhang

Zheng Guo, Jiaqi Cui, Haocheng Xiong et al.

Non-invasive prediction of Gleason Grade Group (GGG) in prostate cancer using multiparametric MRI (mpMRI) is clinically vital for reducing unnecessary biopsies. Existing GGG prediction methods face two major limitations. First, they often overlook non-image information critical for GGG prediction, including age, prostate-specific antigen (PSA), and expert priors embedded in radiology reports. Second, they tend to oversimplify GGG as flat categorical labels, failing to account for its intrinsic hierarchy of primary and secondary Gleason patterns. To this end, we propose a novel Knowledge-Driven Ordinal-Aware Learning (KOAL) framework with three synergistic modules. Specifically, the Clinical-Context Modulation (CCM) module uses clinical variables (e.g., age and PSA) to dynamically modulate discriminative image representations. The Knowledge-Guided Prototype Alignment (KGPA) module leverages an LLM to extract group-specific expert knowledge from training radiology reports and clinical guidelines, producing offline semantic anchors describing grade-specific radiological findings without requiring patient-specific reports at inference. Through prototype contrastive alignment, patient-specific mpMRI representations are matched with these anchors to promote pathology-aligned representation learning. The Hierarchical Ordinal-aware Constraints (HOC) module decouples primary and secondary Gleason pattern prediction and maps their probabilistic outputs to GGG via a Differentiable Bio-logic Mapping Layer (DBML), ensuring pathological grading consistency. Experiments on public PI-CAI and in-house datasets demonstrate that KOAL outperforms state-of-the-art methods. Code is available at: https://github.com/Gother-GZ/KOAL.

Yilin Xiao, Junnan Dong, Chuang Zhou et al.

Graph Retrieval Augmented Generation (GraphRAG) has garnered increasing recognition for its potential to enhance large language models (LLMs) by structurally organizing domain-specific corpora and facilitating complex reasoning. However, current evaluations of GraphRAG models predominantly rely on traditional question-answering datasets. Their limited scope in questions and evaluation metrics fails to comprehensively assess the reasoning capacity improvements enabled by GraphRAG models. To address this gap, we introduce GraphRAG-Bench, a large-scale, domain-specific benchmark designed to rigorously evaluate GraphRAG models. Our benchmark offers three key superiorities: \((i)\) Challenging question design. Featuring college-level, domain-specific questions that demand multi-hop reasoning, the benchmark ensures that simple content retrieval is insufficient for problem-solving. For example, some questions require mathematical reasoning or programming. \((ii)\) Diverse task coverage. The dataset includes a broad spectrum of reasoning tasks, multiple-choice, true/false, multi-select, open-ended, and fill-in-the-blank. It spans 16 disciplines in twenty core textbooks. \((iii)\) Holistic evaluation framework. GraphRAG-Bench provides comprehensive assessment across the entire GraphRAG pipeline, including graph construction, knowledge retrieval, and answer generation. Beyond final-answer correctness, it evaluates the logical coherence of the reasoning process. By applying nine contemporary GraphRAG methods to GraphRAG-Bench, we demonstrate its utility in quantifying how graph-based structuring improves model reasoning capabilities. Our analysis reveals critical insights about graph architectures, retrieval efficacy, and reasoning capabilities, offering actionable guidance for the research community.