Toru Shirakawa

Jessie Z. Li, Zhiqing Hong, Toru Shirakawa et al.

Human mobility trajectories are widely studied in public health and social science, where different demographic groups exhibit significantly different mobility patterns. However, existing trajectory generation models rarely capture this heterogeneity because most trajectory datasets lack demographic labels. To address this gap in data, we propose ATLAS, a weakly supervised approach for demographic-conditioned trajectory generation using only (i) individual trajectories without demographic labels, (ii) region-level aggregated mobility features, and (iii) region-level demographic compositions from census data. ATLAS trains a trajectory generator and fine-tunes it so that simulated mobility matches observed regional aggregates while conditioning on demographics. Experiments on real trajectory data with demographic labels show that ATLAS substantially improves demographic realism over baselines (JSD $\downarrow$ 12%--69%) and closes much of the gap to strongly supervised training. We further develop theoretical analyses for when and why ATLAS works, identifying key factors including demographic diversity across regions and the informativeness of the aggregate feature, paired with experiments demonstrating the practical implications of our theory. We release our code at https://github.com/schang-lab/ATLAS.

Toru Shirakawa, Yi Li, Yulun Wu et al.

We propose Deep Longitudinal Targeted Minimum Loss-based Estimation (Deep LTMLE), a novel approach to estimate the counterfactual mean of outcome under dynamic treatment policies in longitudinal problem settings. Our approach utilizes a transformer architecture with heterogeneous type embedding trained using temporal-difference learning. After obtaining an initial estimate using the transformer, following the targeted minimum loss-based likelihood estimation (TMLE) framework, we statistically corrected for the bias commonly associated with machine learning algorithms. Furthermore, our method also facilitates statistical inference by enabling the provision of 95% confidence intervals grounded in asymptotic statistical theory. Simulation results demonstrate our method's superior performance over existing approaches, particularly in complex, long time-horizon scenarios. It remains effective in small-sample, short-duration contexts, matching the performance of asymptotically efficient estimators. To demonstrate our method in practice, we applied our method to estimate counterfactual mean outcomes for standard versus intensive blood pressure management strategies in a real-world cardiovascular epidemiology cohort study.

Emily Alsentzer, Marie-Laure Charpignon, Bill Chen et al.

The 6th Annual Conference on Health, Inference, and Learning (CHIL 2025), hosted by the Association for Health Learning and Inference (AHLI), was held in person on June 25-27, 2025, at the University of California, Berkeley, in Berkeley, California, USA. As part of this year's program, we hosted Research Roundtables to catalyze collaborative, small-group dialogue around critical, timely topics at the intersection of machine learning and healthcare. Each roundtable was moderated by a team of senior and junior chairs who fostered open exchange, intellectual curiosity, and inclusive engagement. The sessions emphasized rigorous discussion of key challenges, exploration of emerging opportunities, and collective ideation toward actionable directions in the field. In total, eight roundtables were held by 19 roundtable chairs on topics of "Explainability, Interpretability, and Transparency," "Uncertainty, Bias, and Fairness," "Causality," "Domain Adaptation," "Foundation Models," "Learning from Small Medical Data," "Multimodal Methods," and "Scalable, Translational Healthcare Solutions."