Shan Lin

Xiao Liang, Shan Lin, Fei Liu et al.

Deformable Image Registration (DIR) plays a significant role in quantifying deformation in medical data. Recent Deep Learning methods have shown promising accuracy and speedup for registering a pair of medical images. However, in 4D (3D + time) medical data, organ motion, such as respiratory motion and heart beating, can not be effectively modeled by pair-wise methods as they were optimized for image pairs but did not consider the organ motion patterns necessary when considering 4D data. This paper presents ORRN, an Ordinary Differential Equations (ODE)-based recursive image registration network. Our network learns to estimate time-varying voxel velocities for an ODE that models deformation in 4D image data. It adopts a recursive registration strategy to progressively estimate a deformation field through ODE integration of voxel velocities. We evaluate the proposed method on two publicly available lung 4DCT datasets, DIRLab and CREATIS, for two tasks: 1) registering all images to the extreme inhale image for 3D+t deformation tracking and 2) registering extreme exhale to inhale phase images. Our method outperforms other learning-based methods in both tasks, producing the smallest Target Registration Error of 1.24mm and 1.26mm, respectively. Additionally, it produces less than 0.001\% unrealistic image folding, and the computation speed is less than 1 second for each CT volume. ORRN demonstrates promising registration accuracy, deformation plausibility, and computation efficiency on group-wise and pair-wise registration tasks. It has significant implications in enabling fast and accurate respiratory motion estimation for treatment planning in radiation therapy or robot motion planning in thoracic needle insertion.

Ke Ma, Hongkai Chen, Shan Lin

Type 1 diabetes is a serious disease in which individuals are unable to regulate their blood glucose levels, leading to various medical complications. Artificial pancreas (AP) systems have been developed as a solution for type 1 diabetic patients to mimic the behavior of the pancreas and regulate blood glucose levels. However, current AP systems lack detection capabilities for exercise-induced glucose intake, which can last up to 4 to 8 hours. This incapability can lead to hypoglycemia, which if left untreated, could have serious consequences, including death. Existing exercise detection methods are either limited to single sensor data or use inaccurate models for exercise detection, making them less effective in practice. In this work, we propose an ensemble learning framework that combines a data-driven physiological model and a Siamese network to leverage multiple physiological signal streams for exercise detection with high accuracy. To evaluate the effectiveness of our proposed approach, we utilized a public dataset with 12 diabetic patients collected from an 8-week clinical trial. Our approach achieves a true positive rate for exercise detection of 86.4% and a true negative rate of 99.1%, outperforming state-of-the-art solutions.

Eugene P. W. Ang, Lin Shan, Alex C. Kot

In recent years, supervised Person Re-identification (Person ReID) approaches have demonstrated excellent performance. However, when these methods are applied to inputs from a different camera network, they typically suffer from significant performance degradation. Different from most domain adaptation (DA) approaches addressing this issue, we focus on developing a domain generalization (DG) Person ReID model that can be deployed without additional fine-tuning or adaptation. In this paper, we propose the Domain Embedding Expansion (DEX) module. DEX dynamically manipulates and augments deep features based on person and domain labels during training, significantly improving the generalization capability and robustness of Person ReID models to unseen domains. We also developed a light version of DEX (DEXLite), applying negative sampling techniques to scale to larger datasets and reduce memory usage for multi-branch networks. Our proposed DEX and DEXLite can be combined with many existing methods, Bag-of-Tricks (BagTricks), the Multi-Granularity Network (MGN), and Part-Based Convolutional Baseline (PCB), in a plug-and-play manner. With DEX and DEXLite, existing methods can gain significant improvements when tested on other unseen datasets, thereby demonstrating the general applicability of our method. Our solution outperforms the state-of-the-art DG Person ReID methods in all large-scale benchmarks as well as in most the small-scale benchmarks.