Jesse Hamilton

Lixuan Chen, Zhongnan Liu, Jesse Hamilton et al.

Prospective reconstruction is crucial in many clinical applications such as MRI-guided radiotherapy, which demands accurate image reconstruction and fast motion estimation from currently acquired measurements. However, prospective reconstruction remains challenging due to ultra-sparse sampling and stringent latency requirements. In this work, we propose PDMR, a Prospective Dynamic 3D MRI Reconstruction framework with latent-space motion tracking. Our core idea is to learn an efficient and generalizable latent manifold of motion fields offline, enabling rapid online adaptation for prospective reconstruction. Specifically, we parameterize the deformation vector fields (DVFs) on a low-dimensional manifold, effectively reducing the search space for fast online adaptation, and employ a tri-plane representation to achieve geometry-aware and memory-efficient encoding of 3D motion. Experiments on both XCAT digital phantoms and in-house abdominal MRI datasets demonstrate that PDMR achieves high-fidelity and temporally consistent reconstruction across multiple prospective scenarios (Immediate and After-2min), outperforming state-of-the-art retrospective and online methods. Our results suggest a promising pathway toward ultra-fast, motion-aware prospective MRI reconstruction in clinical practice.

Han Ouyang, Jesse Hamilton, Saeed Amal

We utilized a cohort of 214 meningitis patients and 46,303 non-meningitis patients from the MIMIC-III database. After extensive data preprocessing, which included ICD-based cohort selection, one-hot encoding of coding, and a two-stage feature selection process (for both the training set and the testing sets), clinically relevant features such as gender and high-risk ICD codes (including subarachnoid hemorrhage, secondary malignant neoplasm of the brain, and generalized epilepsy) are selected. Overall, these clinically reasonable and temporally adherent features provided excellent modeling performance. Three models (Random Forest, LightGBM, and Deep Neural Networks (DNN) are trained as base models for Ensemble Learning. Base model outputs are aggregated and stacked into a meta model (Logistic Regression) that uses the base model outputs as input values in training. Ultimately, soldier outputs (AUC of Testing Set 1: 0.9637, AUC of Testing Set 2: 0.9472) are obtained through ensemble learning. We created a challenging condition for diagnosing meningitis, simulating a real-world ER (Emergency Room) scenario to enhance clinical use in real-world applications. While directly deploying a diagnostic tool that clinicians can use is challenging, this paper paves the way for a potential future AI-driven diagnostic approach for meningitis using Ensemble Learning.