Ruobing Wang

Qingfei Zhao, Ruobing Wang, Dingling Xu et al.

Large language models (LLMs) have notably progressed in multi-step and long-chain reasoning. However, extending their reasoning capabilities to encompass deep interactions with search remains a non-trivial challenge, as models often fail to identify optimal reasoning-search interaction trajectories, resulting in suboptimal responses. We propose R-Search, a novel reinforcement learning framework for Reasoning-Search integration, designed to enable LLMs to autonomously execute multi-step reasoning with deep search interaction, and learn optimal reasoning search interaction trajectories via multi-reward signals, improving response quality in complex logic- and knowledge-intensive tasks. R-Search guides the LLM to dynamically decide when to retrieve or reason, while globally integrating key evidence to enhance deep knowledge interaction between reasoning and search. During RL training, R-Search provides multi-stage, multi-type rewards to jointly optimize the reasoning-search trajectory. Experiments on seven datasets show that R-Search outperforms advanced RAG baselines by up to 32.2% (in-domain) and 25.1% (out-of-domain). The code and data are available at https://github.com/QingFei1/R-Search.

Md Jahidul Islam, Ruobing Wang, Junaed Sattar

This paper presents a holistic approach to saliency-guided visual attention modeling (SVAM) for use by autonomous underwater robots. Our proposed model, named SVAM-Net, integrates deep visual features at various scales and semantics for effective salient object detection (SOD) in natural underwater images. The SVAM-Net architecture is configured in a unique way to jointly accommodate bottom-up and top-down learning within two separate branches of the network while sharing the same encoding layers. We design dedicated spatial attention modules (SAMs) along these learning pathways to exploit the coarse-level and fine-level semantic features for SOD at four stages of abstractions. The bottom-up branch performs a rough yet reasonably accurate saliency estimation at a fast rate, whereas the deeper top-down branch incorporates a residual refinement module (RRM) that provides fine-grained localization of the salient objects. Extensive performance evaluation of SVAM-Net on benchmark datasets clearly demonstrates its effectiveness for underwater SOD. We also validate its generalization performance by several ocean trials' data that include test images of diverse underwater scenes and waterbodies, and also images with unseen natural objects. Moreover, we analyze its computational feasibility for robotic deployments and demonstrate its utility in several important use cases of visual attention modeling.

Zhiyuan Ma, Ping Wang, Zehui Gao et al.

Warfarin dosing remains challenging due to narrow therapeutic index and highly individual variability. Incorrect warfarin dosing is associated with devastating adverse events. Remarkable efforts have been made to develop the machine learning based warfarin dosing algorithms incorporating clinical factors and genetic variants such as polymorphisms in CYP2C9 and VKORC1. The most widely validated pharmacogenetic algorithm is the IWPC algorithm based on multivariate linear regression (MLR). However, with only a single algorithm, the prediction performance may reach an upper limit even with optimal parameters. Here, we present novel algorithms using stacked generalization frameworks to estimate the warfarin dose, within which different types of machine learning algorithms function together through a meta-machine learning model to maximize the prediction accuracy. Compared to the IWPC-derived MLR algorithm, Stack 1 and 2 based on stacked generalization frameworks performed significantly better overall. Subgroup analysis revealed that the mean of the percentage of patients whose predicted dose of warfarin within 20% of the actual stable therapeutic dose (mean percentage within 20%) for Stack 1 was improved by 12.7% (from 42.47% to 47.86%) in Asians and by 13.5% (from 22.08% to 25.05%) in the low-dose group compared to that for MLR, respectively. These data suggest that our algorithms would especially benefit patients required low warfarin maintenance dose, as subtle changes in warfarin dose could lead to adverse clinical events (thrombosis or bleeding) in patients with low dose. Our study offers novel pharmacogenetic algorithms for clinical trials and practice.