Zachary Shah

Mengze Gao, Zachary Shah, Xiaozhi Cao et al.

Spatiotemporal magnetic field variations from B0-inhomogeneity and diffusion-encoding-induced eddy-currents can be detrimental to rapid image-encoding schemes such as spiral, EPI and 3D-cones, resulting in undesirable image artifacts. In this work, a data driven approach for automatic estimation of these field imperfections is developed by combining autofocus metrics with deep learning, and by leveraging a compact basis representation of the expected field imperfections. The method was applied to single-shot spiral diffusion MRI at high b-values where accurate estimation of B0 and eddy were obtained, resulting in high quality image reconstruction without need for additional external calibrations.

Yonatan Urman, Zachary Shah, Ashwin Kumar et al.

Purpose: To accelerate MRI acquisition by incorporating the previous scans of a subject during reconstruction. Although longitudinal imaging constitutes much of clinical MRI, leveraging previous scans is challenging due to the complex relationship between scan sessions, potentially involving substantial anatomical or pathological changes, and the lack of open-access datasets with both longitudinal pairs and raw k-space needed for training deep learning-based reconstruction models. Methods: We propose a diffusion-model-based reconstruction framework that eliminates the need for longitudinally paired training data. During training, we treat all scan timepoints as samples from the same distribution, therefore requiring only standalone images. At inference, our framework integrates a subject's prior scan in magnitude DICOM format, which is readily available in clinical workflows, to guide reconstruction of the follow-up. To support future development, we introduce an open-access clinical dataset containing multi-session pairs including prior DICOMs and follow-up k-space. Results: Our method consistently outperforms both longitudinal and non-longitudinal baseline reconstruction methods across various accelerated Cartesian acquisition strategies. In imaging regions highly similar to the prior scan, we observe up to 10\% higher SSIM and 2 dB higher PSNR, without degradation in dissimilar areas. Compared to longitudinal reconstruction baselines, our method demonstrates robustness to varying degrees of anatomical change and misregistration. Conclusion: We demonstrate that prior scans can be effectively integrated with state-of-the-art diffusion-based reconstruction methods to improve image quality and enable greater scan acceleration, without requiring an extensive longitudinally-paired training dataset.

Ivan Villa-Renteria, Mason L. Wang, Zachary Shah et al.

We present Subtractive Training, a simple and novel method for synthesizing individual musical instrument stems given other instruments as context. This method pairs a dataset of complete music mixes with 1) a variant of the dataset lacking a specific stem, and 2) LLM-generated instructions describing how the missing stem should be reintroduced. We then fine-tune a pretrained text-to-audio diffusion model to generate the missing instrument stem, guided by both the existing stems and the text instruction. Our results demonstrate Subtractive Training's efficacy in creating authentic drum stems that seamlessly blend with the existing tracks. We also show that we can use the text instruction to control the generation of the inserted stem in terms of rhythm, dynamics, and genre, allowing us to modify the style of a single instrument in a full song while keeping the remaining instruments the same. Lastly, we extend this technique to MIDI formats, successfully generating compatible bass, drum, and guitar parts for incomplete arrangements.