Sharath Chandra Guntuku

Sahaj K. Mistry, Sourav Saini, Aashray Gupta et al.

Brain tumor segmentation plays a crucial role in computer-aided diagnosis. This study introduces a novel segmentation algorithm utilizing a modified nnU-Net architecture. Within the nnU-Net architecture's encoder section, we enhance conventional convolution layers by incorporating omni-dimensional dynamic convolution layers, resulting in improved feature representation. Simultaneously, we propose a multi-scale attention strategy that harnesses contemporary insights from various scales. Our model's efficacy is demonstrated on diverse datasets from the BraTS-2023 challenge. Integrating omni-dimensional dynamic convolution (ODConv) layers and multi-scale features yields substantial improvement in the nnU-Net architecture's performance across multiple tumor segmentation datasets. Remarkably, our proposed model attains good accuracy during validation for the BraTS Africa dataset. The ODconv source code along with full training code is available on GitHub.

Young Min Cho, Sunny Rai, Lyle Ungar et al.

Mental health conversational agents (a.k.a. chatbots) are widely studied for their potential to offer accessible support to those experiencing mental health challenges. Previous surveys on the topic primarily consider papers published in either computer science or medicine, leading to a divide in understanding and hindering the sharing of beneficial knowledge between both domains. To bridge this gap, we conduct a comprehensive literature review using the PRISMA framework, reviewing 534 papers published in both computer science and medicine. Our systematic review reveals 136 key papers on building mental health-related conversational agents with diverse characteristics of modeling and experimental design techniques. We find that computer science papers focus on LLM techniques and evaluating response quality using automated metrics with little attention to the application while medical papers use rule-based conversational agents and outcome metrics to measure the health outcomes of participants. Based on our findings on transparency, ethics, and cultural heterogeneity in this review, we provide a few recommendations to help bridge the disciplinary divide and enable the cross-disciplinary development of mental health conversational agents.

Zepu Wang, Xiaobo Ma, Huajie Yang et al.

Crime forecasting is a critical component of urban analysis and essential for stabilizing society today. Unlike other time series forecasting problems, crime incidents are sparse, particularly in small regions and within specific time periods. Traditional spatial-temporal deep learning models often struggle with this sparsity, as they typically cannot effectively handle the non-Gaussian nature of crime data, which is characterized by numerous zeros and over-dispersed patterns. To address these challenges, we introduce a novel approach termed Spatial Temporal Multivariate Zero-Inflated Negative Binomial Graph Neural Networks (STMGNN-ZINB). This framework leverages diffusion and convolution networks to analyze spatial, temporal, and multivariate correlations, enabling the parameterization of probabilistic distributions of crime incidents. By incorporating a Zero-Inflated Negative Binomial model, STMGNN-ZINB effectively manages the sparse nature of crime data, enhancing prediction accuracy and the precision of confidence intervals. Our evaluation on real-world datasets confirms that STMGNN-ZINB outperforms existing models, providing a more reliable tool for predicting and understanding crime dynamics.

Sharath Chandra Guntuku, Thomas Talhelm, Garrick Sherman et al.

We used natural language processing to analyze a billion words to study cultural differences on Weibo, one of China's largest social media platforms. We compared predictions from two common explanations about cultural differences in China (economic development and urban-rural differences) against the less-obvious legacy of rice versus wheat farming. Rice farmers had to coordinate shared irrigation networks and exchange labor to cope with higher labor requirements. In contrast, wheat relied on rainfall and required half as much labor. We test whether this legacy made southern China more interdependent. Across all word categories, rice explained twice as much variance as economic development and urbanization. Rice areas used more words reflecting tight social ties, holistic thought, and a cautious, prevention orientation. We then used Twitter data comparing prefectures in Japan, which largely replicated the results from China. This provides crucial evidence of the rice theory in a different nation, language, and platform.

Young-Min Cho, Yuan Yuan, Sharath Chandra Guntuku et al.

Style features such as friendly, helpful, or concise are widely used in prompts to steer the behavior of Large Language Model (LLM) conversational agents, yet their unintended side effects remain poorly understood. In this work, we present the first systematic study of cross-feature stylistic side effects. We conduct a comprehensive survey of 127 conversational agent papers from ACL Anthology and identify 12 frequently used style features. Using controlled, synthetic dialogues across task-oriented and open domain settings, we quantify how prompting for one style feature causally affects others via a pairwise LLM as a Judge evaluation framework. Our results reveal consistent and structured side effects, such as prompting for conciseness significantly reduces perceived expertise. They demonstrate that style features are deeply entangled rather than orthogonal. To support future research, we introduce CASSE (Conversational Agent Stylistic Side Effects), a dataset capturing these complex interactions. We further evaluate prompt based and activation steering based mitigation strategies and find that while they can partially restore suppressed traits, they often degrade the primary intended style. These findings challenge the assumption of faithful style control in LLMs and highlight the need for multi-objective and more principled approaches to safe, targeted stylistic steering in conversational agents.

Harry Wang, Sharath Chandra Guntuku

The COVID-19 pandemic has been accompanied by an `infodemic' -- of accurate and inaccurate health information across social media. Detecting misinformation amidst dynamically changing information landscape is challenging; identifying relevant keywords and posts is arduous due to the large amount of human effort required to inspect the content and sources of posts. We aim to reduce the resource cost of this process by introducing a weakly-supervised iterative graph-based approach to detect keywords, topics, and themes related to misinformation, with a focus on COVID-19. Our approach can successfully detect specific topics from general misinformation-related seed words in a few seed texts. Our approach utilizes the BERT-based Word Graph Search (BWGS) algorithm that builds on context-based neural network embeddings for retrieving misinformation-related posts. We utilize Latent Dirichlet Allocation (LDA) topic modeling for obtaining misinformation-related themes from the texts returned by BWGS. Furthermore, we propose the BERT-based Multi-directional Word Graph Search (BMDWGS) algorithm that utilizes greater starting context information for misinformation extraction. In addition to a qualitative analysis of our approach, our quantitative analyses show that BWGS and BMDWGS are effective in extracting misinformation-related content compared to common baselines in low data resource settings. Extracting such content is useful for uncovering prevalent misconceptions and concerns and for facilitating precision public health messaging campaigns to improve health behaviors.

Shubham Chaudhary, Sadbhawna, Vinit Jakhetiya et al.

We propose a two-stage Convolutional Neural Network (CNN) based classification framework for detecting COVID-19 and Community-Acquired Pneumonia (CAP) using the chest Computed Tomography (CT) scan images. In the first stage, an infection - COVID-19 or CAP, is detected using a pre-trained DenseNet architecture. Then, in the second stage, a fine-grained three-way classification is done using EfficientNet architecture. The proposed COVID+CAP-CNN framework achieved a slice-level classification accuracy of over 94% at identifying COVID-19 and CAP. Further, the proposed framework has the potential to be an initial screening tool for differential diagnosis of COVID-19 and CAP, achieving a validation accuracy of over 89.3% at the finer three-way COVID-19, CAP, and healthy classification. Within the IEEE ICASSP 2021 Signal Processing Grand Challenge (SPGC) on COVID-19 Diagnosis, our proposed two-stage classification framework achieved an overall accuracy of 90% and sensitivity of .857, .9, and .942 at distinguishing COVID-19, CAP, and normal individuals respectively, to rank first in the evaluation. Code and model weights are available at https://github.com/shubhamchaudhary2015/ct_covid19_cap_cnn

Young-Min Cho, Sharath Chandra Guntuku, Lyle Ungar

Recent advancements in Large Language Models (LLMs) have enabled the emergence of multi-agent systems where LLMs interact, collaborate, and make decisions in shared environments. While individual model behavior has been extensively studied, the dynamics of peer influence in such systems remain underexplored. In this paper, we investigate herd behavior, the tendency of agents to align their outputs with those of their peers, within LLM-based multi-agent interactions. We present a series of controlled experiments that reveal how herd behaviors are shaped by multiple factors. First, we show that the gap between self-confidence and perceived confidence in peers significantly impacts an agent's likelihood to conform. Second, we find that the format in which peer information is presented plays a critical role in modulating the strength of herd behavior. Finally, we demonstrate that the degree of herd behavior can be systematically controlled, and that appropriately calibrated herd tendencies can enhance collaborative outcomes. These findings offer new insights into the social dynamics of LLM-based systems and open pathways for designing more effective and adaptive multi-agent collaboration frameworks.

Young-Min Cho, Dandan Pang, Stuti Thapa et al.

While affective expressions on social media have been extensively studied, most research has focused on the Western context. This paper explores cultural differences in affective expressions by comparing valence and arousal on Twitter/X (geolocated to the US) and Sina Weibo (in Mainland China). Using the NRC-VAD lexicon to measure valence and arousal, we identify distinct patterns of emotional expression across both platforms. Our analysis reveals a functional representation between valence and arousal, showing a negative offset in contrast to traditional lab-based findings which suggest a positive offset. Furthermore, we uncover significant cross-cultural differences in arousal, with US users displaying higher emotional intensity than Chinese users, regardless of the valence of the content. Finally, we conduct a comprehensive language analysis correlating n-grams and LDA topics with affective dimensions to deepen our understanding of how language and culture shape emotional expression. These findings contribute to a more nuanced understanding of affective communication across cultural and linguistic contexts on social media.

Aaron Xuxiang Tian, Ruofan Zhang, Jiayao Tang et al.

We study multi-turn multi-agent orchestration, where multiple large language model (LLM) agents interact over multiple turns by iteratively proposing answers or casting votes until reaching consensus. Using four LLMs (Gemini 2.5 Pro, GPT-5, Grok 4, and Claude Sonnet 4) on GPQA-Diamond, IFEval, and MuSR, we conduct two experiments: (i) benchmarking orchestration against single-LLM baselines; and (ii) ablations on GPQA-Diamond that vary whether agents see who authored answers and whether they can observe ongoing votes. Orchestration matches or exceeds the strongest single model and consistently outperforms the others. Analysis of best-achievable orchestration performance shows potential for further gains. The ablations show that revealing authorship increases self-voting and ties, and that showing ongoing votes amplifies herding, which speeds convergence but can sometimes yield premature consensus.

Neil K. R. Sehgal, Jena Shaw Tronieri, Lyle Ungar et al.

Social media can reveal patient experiences with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) that extend beyond clinical trial data. We analyzed 410,198 Reddit posts (May 2019-June 2025) mentioning semaglutide or tirzepatide. A total of 67,008 users self-reported using these medications, and 43.5% described at least one side effect. Gastrointestinal symptoms predominated, including nausea (36.9%), fatigue (16.7%), vomiting (16.3%), constipation (15.3%), and diarrhea (12.6%). Notably, reproductive symptoms (e.g., menstrual irregularities) and temperature-related complaints (e.g., chills, hot flashes) emerged as unrecognized potential effects. These findings highlight patient concerns not well captured in current labeling or trials. Large-scale social media analysis can complement traditional pharmacovigilance by detecting emerging safety signals and expanding understanding of the real-world safety profile of GLP-1 RAs.

Shreya Havaldar, Salvatore Giorgi, Sunny Rai et al.

Cultural variation exists between nations (e.g., the United States vs. China), but also within regions (e.g., California vs. Texas, Los Angeles vs. San Francisco). Measuring this regional cultural variation can illuminate how and why people think and behave differently. Historically, it has been difficult to computationally model cultural variation due to a lack of training data and scalability constraints. In this work, we introduce a new research problem for the NLP community: How do we measure variation in cultural constructs across regions using language? We then provide a scalable solution: building knowledge-guided lexica to model cultural variation, encouraging future work at the intersection of NLP and cultural understanding. We also highlight modern LLMs' failure to measure cultural variation or generate culturally varied language.

Shubham Innani, Prasad Dutande, Ujjwal Baid et al.

Skin cancer is a serious condition that requires accurate diagnosis and treatment. One way to assist clinicians in this task is using computer-aided diagnosis (CAD) tools that automatically segment skin lesions from dermoscopic images. We propose a novel adversarial learning-based framework called Efficient-GAN (EGAN) that uses an unsupervised generative network to generate accurate lesion masks. It consists of a generator module with a top-down squeeze excitation-based compound scaled path, an asymmetric lateral connection-based bottom-up path, and a discriminator module that distinguishes between original and synthetic masks. A morphology-based smoothing loss is also implemented to encourage the network to create smooth semantic boundaries of lesions. The framework is evaluated on the International Skin Imaging Collaboration (ISIC) Lesion Dataset 2018. It outperforms the current state-of-the-art skin lesion segmentation approaches with a Dice coefficient, Jaccard similarity, and Accuracy of 90.1%, 83.6%, and 94.5%, respectively. We also design a lightweight segmentation framework (MGAN) that achieves comparable performance as EGAN but with an order of magnitude lower number of training parameters, thus resulting in faster inference times for low compute resource settings.

Jesse Cui, Tingdan Zhang, Kokil Jaidka et al.

Modeling differential stress expressions in urban and rural regions in China can provide a better understanding of the effects of urbanization on psychological well-being in a country that has rapidly grown economically in the last two decades. This paper studies linguistic differences in the experiences and expressions of stress in urban-rural China from Weibo posts from over 65,000 users across 329 counties using hierarchical mixed-effects models. We analyzed phrases, topical themes, and psycho-linguistic word choices in Weibo posts mentioning stress to better understand appraisal differences surrounding psychological stress in urban and rural communities in China; we then compared them with large-scale polls from Gallup. After controlling for socioeconomic and gender differences, we found that rural communities tend to express stress in emotional and personal themes such as relationships, health, and opportunity while users in urban areas express stress using relative, temporal, and external themes such as work, politics, and economics. These differences exist beyond controlling for GDP and urbanization, indicating a fundamentally different lifestyle between rural and urban residents in very specific environments, arguably having different sources of stress. We found corroborative trends in physical, financial, and social wellness with urbanization in Gallup polls.

Anietie Andy, Sharath Guntuku

Individuals recovering from substance use often seek social support (emotional and informational) on online recovery forums, where they can both write and comment on posts, expressing their struggles and successes. A common challenge in these forums is that certain posts (some of which may be support seeking) receive no comments. In this work, we use data from two Reddit substance recovery forums:/r/Leaves and/r/OpiatesRecovery, to determine the relationship between the social supports expressed in the titles of posts and the number of comments they receive. We show that the types of social support expressed in post titles that elicit comments vary from one substance use recovery forum to the other.

Roshan Santosh, H. Andrew Schwartz, Johannes C. Eichstaedt et al.

In this paper, we present an iterative graph-based approach for the detection of symptoms of COVID-19, the pathology of which seems to be evolving. More generally, the method can be applied to finding context-specific words and texts (e.g. symptom mentions) in large imbalanced corpora (e.g. all tweets mentioning #COVID-19). Given the novelty of COVID-19, we also test if the proposed approach generalizes to the problem of detecting Adverse Drug Reaction (ADR). We find that the approach applied to Twitter data can detect symptom mentions substantially before being reported by the Centers for Disease Control (CDC).

Salvatore Giorgi, Sharath Chandra Guntuku, McKenzie Himelein-Wachowiak et al.

Black Lives Matter (BLM) is a decentralized social movement protesting violence against Black individuals and communities, with a focus on police brutality. The movement gained significant attention following the killings of Ahmaud Arbery, Breonna Taylor, and George Floyd in 2020. The #BlackLivesMatter social media hashtag has come to represent the grassroots movement, with similar hashtags counter protesting the BLM movement, such as #AllLivesMatter, and #BlueLivesMatter. We introduce a data set of 63.9 million tweets from 13.0 million users from over 100 countries which contain one of the following keywords: BlackLivesMatter, AllLivesMatter, and BlueLivesMatter. This data set contains all currently available tweets from the beginning of the BLM movement in 2013 to 2021. We summarize the data set and show temporal trends in use of both the BlackLivesMatter keyword and keywords associated with counter movements. Additionally, for each keyword, we create and release a set of Latent Dirichlet Allocation (LDA) topics (i.e., automatically clustered groups of semantically co-occuring words) to aid researchers in identifying linguistic patterns across the three keywords.

Sharath Chandra Guntuku, Mingyang Li, Louis Tay et al.

Global acceptance of Emojis suggests a cross-cultural, normative use of Emojis. Meanwhile, nuances in Emoji use across cultures may also exist due to linguistic differences in expressing emotions and diversity in conceptualizing topics. Indeed, literature in cross-cultural psychology has found both normative and culture-specific ways in which emotions are expressed. In this paper, using social media, we compare the Emoji usage based on frequency, context, and topic associations across countries in the East (China and Japan) and the West (United States, United Kingdom, and Canada). Across the East and the West, our study examines a) similarities and differences on the usage of different categories of Emojis such as People, Food \& Drink, Travel \& Places etc., b) potential mapping of Emoji use differences with previously identified cultural differences in users' expression about diverse concepts such as death, money emotions and family, and c) relative correspondence of validated psycho-linguistic categories with Ekman's emotions. The analysis of Emoji use in the East and the West reveals recognizable normative and culture specific patterns. This research reveals the ways in which Emojis can be used for cross-cultural communication.

Sharath Chandra Guntuku, Daniel Preotiuc-Pietro, Johannes C. Eichstaedt et al.

Previous work has found strong links between the choice of social media images and users' emotions, demographics and personality traits. In this study, we examine which attributes of profile and posted images are associated with depression and anxiety of Twitter users. We used a sample of 28,749 Facebook users to build a language prediction model of survey-reported depression and anxiety, and validated it on Twitter on a sample of 887 users who had taken anxiety and depression surveys. We then applied it to a different set of 4,132 Twitter users to impute language-based depression and anxiety labels, and extracted interpretable features of posted and profile pictures to uncover the associations with users' depression and anxiety, controlling for demographics. For depression, we find that profile pictures suppress positive emotions rather than display more negative emotions, likely because of social media self-presentation biases. They also tend to show the single face of the user (rather than show her in groups of friends), marking increased focus on the self, emblematic for depression. Posted images are dominated by grayscale and low aesthetic cohesion across a variety of image features. Profile images of anxious users are similarly marked by grayscale and low aesthetic cohesion, but less so than those of depressed users. Finally, we show that image features can be used to predict depression and anxiety, and that multitask learning that includes a joint modeling of demographics improves prediction performance. Overall, we find that the image attributes that mark depression and anxiety offer a rich lens into these conditions largely congruent with the psychological literature, and that images on Twitter allow inferences about the mental health status of users.

Sharath Chandra Guntuku, Anneke Buffone, Kokil Jaidka et al.

A body of literature has demonstrated that users' mental health conditions, such as depression and anxiety, can be predicted from their social media language. There is still a gap in the scientific understanding of how psychological stress is expressed on social media. Stress is one of the primary underlying causes and correlates of chronic physical illnesses and mental health conditions. In this paper, we explore the language of psychological stress with a dataset of 601 social media users, who answered the Perceived Stress Scale questionnaire and also consented to share their Facebook and Twitter data. Firstly, we find that stressed users post about exhaustion, losing control, increased self-focus and physical pain as compared to posts about breakfast, family-time, and travel by users who are not stressed. Secondly, we find that Facebook language is more predictive of stress than Twitter language. Thirdly, we demonstrate how the language based models thus developed can be adapted and be scaled to measure county-level trends. Since county-level language is easily available on Twitter using the Streaming API, we explore multiple domain adaptation algorithms to adapt user-level Facebook models to Twitter language. We find that domain-adapted and scaled social media-based measurements of stress outperform sociodemographic variables (age, gender, race, education, and income), against ground-truth survey-based stress measurements, both at the user- and the county-level in the U.S. Twitter language that scores higher in stress is also predictive of poorer health, less access to facilities and lower socioeconomic status in counties. We conclude with a discussion of the implications of using social media as a new tool for monitoring stress levels of both individuals and counties.

Sharath Chandra Guntuku, Michael James Scott, Gheorghita Ghinea et al.

Whilst affective responses to various forms and genres of multimedia content have been well researched, precious few studies have investigated the combined impact that multimedia system parameters and human factors have on affect. Consequently, in this paper we explore the role that two primordial dimensions of human factors - personality and culture - in conjunction with system factors - frame rate, resolution, and bit rate - have on user affect and enjoyment of multimedia presentations. To this end, a two-site, cross-cultural study was undertaken, the results of which produced three predictve models. Personality and Culture traits were shown statistically to represent 5.6% of the variance in positive affect, 13.6% in negative affect and 9.3% in enjoyment. The correlation between affect and enjoyment, was significant. Predictive modeling incorporating human factors showed about 8%, 7% and 9% improvement in predicting positive affect, negative affect and enjoyment respectively when compared to models trained only on system factors. Results and analysis indicate the significant role played by human factors in influencing affect that users experience while watching multimedia.

Sharath Chandra Guntuku, Pratik Narang, Chittaranjan Hota

Over the past decade, the Cyberspace has seen an increasing number of attacks coming from botnets using the Peer-to-Peer (P2P) architecture. Peer-to-Peer botnets use a decentralized Command & Control architecture. Moreover, a large number of such botnets already exist, and newer versions- which significantly differ from their parent bot- are also discovered practically every year. In this work, the authors propose and implement a novel hybrid framework for detecting P2P botnets in live network traffic by integrating Neural Networks with Bayesian Regularization. Bayesian Regularization helps in achieving better generalization of the dataset, thereby enabling the detection of botnet activity even of those bots which were never used in training the Neural Network. Hence such a framework is suitable for detection of newer and unseen botnets in live traffic of a network. This was verified by testing the Framework on test data unseen to the Detection module (using untrained botnet dataset), and the authors were successful in detecting this activity with an accuracy of 99.2 %.