Kayhan N. Batmanghelich

Maxwell Reynolds, Chaitanya Srinivasan, Vijay Cherupally et al.

Discovery of sensitive and biologically grounded biomarkers is essential for early detection and monitoring of Alzheimer's disease (AD). Structural MRI is widely available but typically relies on hand-crafted features such as cortical thickness or volume. We ask whether self-supervised learning (SSL) can uncover more powerful biomarkers from the same data. Existing SSL methods underperform FreeSurfer-derived features in disease classification, conversion prediction, and amyloid status prediction. We introduce Residual Noise Contrastive Estimation (R-NCE), a new SSL framework that integrates auxiliary FreeSurfer features while maximizing additional augmentation-invariant information. R-NCE outperforms traditional features and existing SSL methods across multiple benchmarks, including AD conversion prediction. To assess biological relevance, we derive Brain Age Gap (BAG) measures and perform genome-wide association studies. R-NCE-BAG shows high heritability and associations with MAPT and IRAG1, with enrichment in astrocytes and oligodendrocytes, indicating sensitivity to neurodegenerative and cerebrovascular processes.

Chenyu Wang, Tianle Chen, H. M. Sabbir Ahmad et al.

Uncertainty quantification (UQ) is vital for ensuring that vision-language models (VLMs) behave safely and reliably. A central challenge is to localize uncertainty to its source, determining whether it arises from the image, the text, or misalignment between the two. We introduce VLM-UQBench, a benchmark for modality-specific and cross-modal data uncertainty in VLMs, It consists of 600 real-world samples drawn from the VizWiz dataset, curated into clean, image-, text-, and cross-modal uncertainty subsets, and a scalable perturbation pipeline with 8 visual, 5 textual, and 3 cross-modal perturbations. We further propose two simple metrics that quantify the sensitivity of UQ scores to these perturbations and their correlation with hallucinations, and use them to evaluate a range of UQ methods across four VLMs and three datasets. Empirically, we find that: (i) existing UQ methods exhibit strong modality-specific specialization and substantial dependence on the underlying VLM, (ii) modality-specific uncertainty frequently co-occurs with hallucinations while current UQ scores provide only weak and inconsistent risk signals, and (iii) although UQ methods can rival reasoning-based chain-of-thought baselines on overt, group-level ambiguity, they largely fail to detect the subtle, instance-level ambiguity introduced by our perturbation pipeline. These results highlight a significant gap between current UQ practices and the fine-grained, modality-aware uncertainty required for reliable VLM deployment.