Huamin Qu

Qipeng Wang, Rui Sheng, Yafei Li et al.

Recent advancements in Large Language Models (LLMs) have demonstrated significant promise in clinical diagnosis. However, current models struggle to emulate the iterative, diagnostic hypothesis-driven reasoning of real clinical scenarios. Specifically, current LLMs suffer from three critical limitations: (1) generating hallucinated medical content due to weak grounding in verified knowledge, (2) asking redundant or inefficient questions rather than discriminative ones that hinder diagnostic progress, and (3) losing coherence over multi-turn dialogues, leading to contradictory or inconsistent conclusions. To address these challenges, we propose MedKGI, a diagnostic framework grounded in clinical practices. MedKGI integrates a medical knowledge graph (KG) to constrain reasoning to validated medical ontologies, selects questions based on information gain to maximize diagnostic efficiency, and adopts an OSCE-format structured state to maintain consistent evidence tracking across turns. Experiments on clinical benchmarks show that MedKGI outperforms strong LLM baselines in both diagnostic accuracy and inquiry efficiency, improving dialogue efficiency by 30% on average while maintaining state-of-the-art accuracy.

Jianben He, Xingbo Wang, Shiyi Liu et al.

Large language models (LLMs) have exhibited impressive abilities for multimodal content comprehension and reasoning with proper prompting in zero- or few-shot settings. Despite the proliferation of interactive systems developed to support prompt engineering for LLMs across various tasks, most have primarily focused on textual or visual inputs, thus neglecting the complex interplay between modalities within multimodal inputs. This oversight hinders the development of effective prompts that guide model multimodal reasoning processes by fully exploiting the rich context provided by multiple modalities. In this paper, we present POEM, a visual analytics system to facilitate efficient prompt engineering for enhancing the multimodal reasoning performance of LLMs. The system enables users to explore the interaction patterns across modalities at varying levels of detail for a comprehensive understanding of the multimodal knowledge elicited by various prompts. Through diverse recommendations of demonstration examples and instructional principles, POEM supports users in iteratively crafting and refining prompts to better align and enhance model knowledge with human insights. The effectiveness and efficiency of our system are validated through two case studies and interviews with experts.