Yutong Guo

Jingyao Cai, Shuaijun Liu, Abdul Rehman et al.

Large Language Models (LLMs) have substantially advanced persona-based dialogue agents for emotion-sensitive role simulation in healthcare, education, counseling, customer service, and interactive storytelling. However, two related lines of work leave a key gap. Persona-based dialogue systems often encode emotions as static traits or surface-level stylistic cues, and affective dialogue research has largely focused on empathetic response generation toward users rather than modeling the agent persona's own evolving emotional state. As a result, trigger-driven emotional evolution within a character remains underexplored. To address this limitation, we draw inspiration from the Component Process Model (CPM), a psychological theory that views emotion as a dynamic process shaped by the appraisal of external events. We propose CPM-MultiAgent, a CPM-grounded emotion evolution multi-agent framework for supporting emotional changes in persona-based dialogue. Instead of treating a character's emotion as a fixed attribute, CPM-MultiAgent represents it as a latent state that is continuously reshaped by dialogue triggers. Through affective trigger extraction, CPM-based collaborative appraisal, and emotion state updating, the framework enables more emotionally consistent role simulation in multi-turn interactions.Experiments with baseline comparisons, ablation studies, human evaluation, and case analyses demonstrate that CPM-MultiAgent effectively models dynamic emotional evolution in emotionally sensitive role-simulation settings.

Kewei Li, Yuqian Wu, Yinheng Li et al.

Since the mechanism of action of drug molecules in the human body is difficult to reproduce in the in vitro environment, it becomes difficult to reveal the causes of the activity cliff phenomenon of drug molecules. We found out the AC of small molecules has been extensively investigated but limited knowledge is accumulated about the AC phenomenon in peptides with canonical amino acids. Understanding the mechanism of AC in canonical amino acids might help understand the one in drug molecules. This study introduces a quantitative definition and benchmarking framework AMPCliff for the AC phenomenon in antimicrobial peptides (AMPs) composed by canonical amino acids. A comprehensive analysis of the existing AMP dataset reveals a significant prevalence of AC within AMPs. AMPCliff quantifies the activities of AMPs by the MIC, and defines 0.9 as the minimum threshold for the normalized BLOSUM62 similarity score between a pair of aligned peptides with at least two-fold MIC changes. This study establishes a benchmark dataset of paired AMPs in Staphylococcus aureus from the publicly available AMP dataset GRAMPA, and conducts a rigorous procedure to evaluate various AMP AC prediction models, including nine machine learning, four deep learning algorithms, four masked language models, and four generative language models. Our analysis reveals that these models are capable of detecting AMP AC events and the pre-trained protein language model ESM2 demonstrates superior performance across the evaluations. The predictive performance of AMP activity cliffs remains to be further improved, considering that ESM2 with 33 layers only achieves the Spearman correlation coefficient 0.4669 for the regression task of the MIC values on the benchmark dataset. Source code and additional resources are available at https://www.healthinformaticslab.org/supp/ or https://github.com/Kewei2023/AMPCliff-generation.

Guo Yutong, Wanying Wang, Yue Wu et al.

Table Visual Question Answering (Table VQA) is typically addressed by large vision-language models (VLMs). While such models can answer directly from images, they often miss fine-grained details unless scaled to very large sizes, which are computationally prohibitive, especially for mobile deployment. A lighter alternative is to have a small VLM perform OCR and then use a large language model (LLM) to reason over structured outputs such as Markdown tables. However, these representations are not naturally optimized for LLMs and still introduce substantial errors. We propose TALENT (Table VQA via Augmented Language-Enhanced Natural-text Transcription), a lightweight framework that leverages dual representations of tables. TALENT prompts a small VLM to produce both OCR text and natural language narration, then combines them with the question for reasoning by an LLM. This reframes Table VQA as an LLM-centric multimodal reasoning task, where the VLM serves as a perception-narration module rather than a monolithic solver. Additionally, we construct ReTabVQA, a more challenging Table VQA dataset requiring multi-step quantitative reasoning over table images. Experiments show that TALENT enables a small VLM-LLM combination to match or surpass a single large VLM at significantly lower computational cost on both public datasets and ReTabVQA.