Xueping Peng

Wenpeng Lu, Sibo Wei, Xueping Peng et al.

By summarizing longer consumer health questions into shorter and essential ones, medical question-answering systems can more accurately understand consumer intentions and retrieve suitable answers. However, medical question summarization is very challenging due to obvious distinctions in health trouble descriptions from patients and doctors. Although deep learning has been applied to successfully address the medical question summarization (MQS) task, two challenges remain: how to correctly capture question focus to model its semantic intention, and how to obtain reliable datasets to fairly evaluate performance. To address these challenges, this paper proposes a novel medical question summarization framework based on entity-driven contrastive learning (ECL). ECL employs medical entities present in frequently asked questions (FAQs) as focuses and devises an effective mechanism to generate hard negative samples. This approach compels models to focus on essential information and consequently generate more accurate question summaries. Furthermore, we have discovered that some MQS datasets, such as the iCliniq dataset with a 33% duplicate rate, have significant data leakage issues. To ensure an impartial evaluation of the related methods, this paper carefully examines leaked samples to reorganize more reasonable datasets. Extensive experiments demonstrate that our ECL method outperforms the existing methods and achieves new state-of-the-art performance, i.e., 52.85, 43.16, 41.31, 43.52 in terms of ROUGE-1 metric on MeQSum, CHQ-Summ, iCliniq, HealthCareMagic dataset, respectively. The code and datasets are available at https://github.com/yrbobo/MQS-ECL.

Sibo Wei, Xueping Peng, Yi-Fei Wang et al.

The surge of large language models (LLMs) has driven significant progress in medical applications, including traditional Chinese medicine (TCM). However, current medical LLMs struggle with TCM diagnosis and syndrome differentiation due to substantial differences between TCM and modern medical theory, and the scarcity of specialized, high-quality corpora. To this end, in this paper we propose BianCang, a TCM-specific LLM, using a two-stage training process that first injects domain-specific knowledge and then aligns it through targeted stimulation to enhance diagnostic and differentiation capabilities. Specifically, we constructed pre-training corpora, instruction-aligned datasets based on real hospital records, and the ChP-TCM dataset derived from the Pharmacopoeia of the People's Republic of China. We compiled extensive TCM and medical corpora for continual pre-training and supervised fine-tuning, building a comprehensive dataset to refine the model's understanding of TCM. Evaluations across 11 test sets involving 31 models and 4 tasks demonstrate the effectiveness of BianCang, offering valuable insights for future research. Code, datasets, and models are available on https://github.com/QLU-NLP/BianCang.

Xueping Peng, Guodong Long, Tao Shen et al.

Sequential diagnosis prediction on the Electronic Health Record (EHR) has been proven crucial for predictive analytics in the medical domain. EHR data, sequential records of a patient's interactions with healthcare systems, has numerous inherent characteristics of temporality, irregularity and data insufficiency. Some recent works train healthcare predictive models by making use of sequential information in EHR data, but they are vulnerable to irregular, temporal EHR data with the states of admission/discharge from hospital, and insufficient data. To mitigate this, we propose an end-to-end robust transformer-based model called SETOR, which exploits neural ordinary differential equation to handle both irregular intervals between a patient's visits with admitted timestamps and length of stay in each visit, to alleviate the limitation of insufficient data by integrating medical ontology, and to capture the dependencies between the patient's visits by employing multi-layer transformer blocks. Experiments conducted on two real-world healthcare datasets show that, our sequential diagnoses prediction model SETOR not only achieves better predictive results than previous state-of-the-art approaches, irrespective of sufficient or insufficient training data, but also derives more interpretable embeddings of medical codes. The experimental codes are available at the GitHub repository (https://github.com/Xueping/SETOR).

Xueping Peng, Guodong Long, Tao Shen et al.

Understanding patients' journeys in healthcare system is a fundamental prepositive task for a broad range of AI-based healthcare applications. This task aims to learn an informative representation that can comprehensively encode hidden dependencies among medical events and its inner entities, and then the use of encoding outputs can greatly benefit the downstream application-driven tasks. A patient journey is a sequence of electronic health records (EHRs) over time that is organized at multiple levels: patient, visits and medical codes. The key challenge of patient journey understanding is to design an effective encoding mechanism which can properly tackle the aforementioned multi-level structured patient journey data with temporal sequential visits and a set of medical codes. This paper proposes a novel self-attention mechanism that can simultaneously capture the contextual and temporal relationships hidden in patient journeys. A multi-level self-attention network (MusaNet) is specifically designed to learn the representations of patient journeys that is used to be a long sequence of activities. The MusaNet is trained in end-to-end manner using the training data derived from EHRs. We evaluated the efficacy of our method on two medical application tasks with real-world benchmark datasets. The results have demonstrated the proposed MusaNet produces higher-quality representations than state-of-the-art baseline methods. The source code is available in https://github.com/xueping/MusaNet.

Rongyao Wang, Wenpeng Lu, Shoujin Wang et al.

News recommender systems are essential for helping users to efficiently and effectively find out those interesting news from a large amount of news. Most of existing news recommender systems usually learn topic-level representations of users and news for recommendation, and neglect to learn more informative aspect-level features of users and news for more accurate recommendation. As a result, they achieve limited recommendation performance. Aiming at addressing this deficiency, we propose a novel Aspect-driven News Recommender System (ANRS) built on aspect-level user preference and news representation learning. Here, news aspect is fine-grained semantic information expressed by a set of related words, which indicates specific aspects described by the news. In ANRS, news aspect-level encoder and user aspect-level encoder are devised to learn the fine-grained aspect-level representations of user's preferences and news characteristics respectively, which are fed into click predictor to judge the probability of the user clicking the candidate news. Extensive experiments are done on the commonly used real-world dataset MIND, which demonstrate the superiority of our method compared with representative and state-of-the-art methods.

Xueping Peng, Guodong Long, Tao Shen et al.

Representation learning on electronic health records (EHRs) plays a vital role in downstream medical prediction tasks. Although natural language processing techniques, such as recurrent neural networks, and self-attention, have been adapted for learning medical representations from hierarchical, time-stamped EHR data, they often struggle when either general or task-specific data are limited. Recent efforts have attempted to mitigate this challenge by incorporating medical ontologies (i.e., knowledge graphs) into self-supervised tasks like diagnosis prediction. However, two main issues remain: (1) small and uniform ontologies that lack diversity for robust learning, and (2) insufficient attention to the critical contexts or dependencies underlying patient journeys, which could further enhance ontology-based learning. To address these gaps, we propose MIPO (Mutual Integration of Patient Journey and Medical Ontology), a robust end-to-end framework that employs a Transformer-based architecture for representation learning. MIPO emphasizes task-specific representation learning through a sequential diagnosis prediction task, while also incorporating an ontology-based disease-typing task. A graph-embedding module is introduced to integrate information from patient visit records, thus alleviating data insufficiency. This setup creates a mutually reinforcing loop, where both patient-journey embedding and ontology embedding benefit from each other. We validate MIPO on two real-world benchmark datasets, showing that it consistently outperforms baseline methods under both sufficient and limited data conditions. Furthermore, the resulting diagnosis embeddings offer improved interpretability, underscoring the promise of MIPO for real-world healthcare applications.

Xueping Peng, Guodong Long, Tao Shen et al.

Electronic health records (EHRs) are longitudinal records of a patient's interactions with healthcare systems. A patient's EHR data is organized as a three-level hierarchy from top to bottom: patient journey - all the experiences of diagnoses and treatments over a period of time; individual visit - a set of medical codes in a particular visit; and medical code - a specific record in the form of medical codes. As EHRs begin to amass in millions, the potential benefits, which these data might hold for medical research and medical outcome prediction, are staggering - including, for example, predicting future admissions to hospitals, diagnosing illnesses or determining the efficacy of medical treatments. Each of these analytics tasks requires a domain knowledge extraction method to transform the hierarchical patient journey into a vector representation for further prediction procedure. The representations should embed a sequence of visits and a set of medical codes with a specific timestamp, which are crucial to any downstream prediction tasks. Hence, expressively powerful representations are appealing to boost learning performance. To this end, we propose a novel self-attention mechanism that captures the contextual dependency and temporal relationships within a patient's healthcare journey. An end-to-end bidirectional temporal encoder network (BiteNet) then learns representations of the patient's journeys, based solely on the proposed attention mechanism. We have evaluated the effectiveness of our methods on two supervised prediction and two unsupervised clustering tasks with a real-world EHR dataset. The empirical results demonstrate the proposed BiteNet model produces higher-quality representations than state-of-the-art baseline methods.

Xueping Peng, Guodong Long, Tao Shen et al.

In longitudinal electronic health records (EHRs), the event records of a patient are distributed over a long period of time and the temporal relations between the events reflect sufficient domain knowledge to benefit prediction tasks such as the rate of inpatient mortality. Medical concept embedding as a feature extraction method that transforms a set of medical concepts with a specific time stamp into a vector, which will be fed into a supervised learning algorithm. The quality of the embedding significantly determines the learning performance over the medical data. In this paper, we propose a medical concept embedding method based on applying a self-attention mechanism to represent each medical concept. We propose a novel attention mechanism which captures the contextual information and temporal relationships between medical concepts. A light-weight neural net, "Temporal Self-Attention Network (TeSAN)", is then proposed to learn medical concept embedding based solely on the proposed attention mechanism. To test the effectiveness of our proposed methods, we have conducted clustering and prediction tasks on two public EHRs datasets comparing TeSAN against five state-of-the-art embedding methods. The experimental results demonstrate that the proposed TeSAN model is superior to all the compared methods. To the best of our knowledge, this work is the first to exploit temporal self-attentive relations between medical events.