Xingyu Fan

Xingyu Fan, Feifei Li, Wenhui Que et al.

Conversational agents deployed in industrial-scale official account platforms must generate responses that are both contextually grounded and stylistically aligned-requirements that existing methods struggle to meet. Chain-of-thought (CoT) prompting induces significant latency due to multi-turn reasoning; per-account fine-tuning is computationally prohibitive; and long prompt-based methods degrade the model's ability to grasp injected context and style. In this paper, we propose WeStar, a lite-adaptive framework for stylized contextual question answering that scales to millions of official accounts. WeStar combines context-grounded generation via RAG with style-aware generation using Parametric RAG (PRAG), where LoRA modules are dynamically activated per style cluster. Our contributions are fourfold: (1) We introduce WeStar, a unified framework capable of serving large volumes of official accounts with minimal overhead. (2) We propose a multi-dimensional, cluster-based parameter sharing scheme that enables compact style representation while preserving stylistic diversity. (3) We develop a style-enhanced Direct Preference Optimization (SeDPO) method to optimize each style cluster's parameters for improved generation quality. (4) Experiments on a large-scale industrial dataset validate the effectiveness and efficiency of WeStar, underscoring its pracitical value in real-world deployment.

Qinze Yu, Zhihang Dong, Xingyu Fan et al.

Identifying the targets of an antimicrobial peptide is a fundamental step in studying the innate immune response and combating antibiotic resistance, and more broadly, precision medicine and public health. There have been extensive studies on the statistical and computational approaches to identify (i) whether a peptide is an antimicrobial peptide (AMP) or a non-AMP and (ii) which targets are these sequences effective to (Gram-positive, Gram-negative, etc.). Despite the existing deep learning methods on this problem, most of them are unable to handle the small AMP classes (anti-insect, anti-parasite, etc.). And more importantly, some AMPs can have multiple targets, which the previous methods fail to consider. In this study, we build a diverse and comprehensive multi-label protein sequence database by collecting and cleaning amino acids from various AMP databases. To generate efficient representations and features for the small classes dataset, we take advantage of a protein language model trained on 250 million protein sequences. Based on that, we develop an end-to-end hierarchical multi-label deep forest framework, HMD-AMP, to annotate AMP comprehensively. After identifying an AMP, it further predicts what targets the AMP can effectively kill from eleven available classes. Extensive experiments suggest that our framework outperforms state-of-the-art models in both the binary classification task and the multi-label classification task, especially on the minor classes.The model is robust against reduced features and small perturbations and produces promising results. We believe HMD-AMP contributes to both the future wet-lab investigations of the innate structural properties of different antimicrobial peptides and build promising empirical underpinnings for precise medicine with antibiotics.