LGMay 28, 2022
TFLEX: Temporal Feature-Logic Embedding Framework for Complex Reasoning over Temporal Knowledge GraphXueyuan Lin, Chengjin Xu, Haihong E et al.
Multi-hop logical reasoning over knowledge graph (KG) plays a fundamental role in many artificial intelligence tasks. Recent complex query embedding (CQE) methods for reasoning focus on static KGs, while temporal knowledge graphs (TKGs) have not been fully explored. Reasoning over TKGs has two challenges: 1. The query should answer entities or timestamps; 2. The operators should consider both set logic on entity set and temporal logic on timestamp set. To bridge this gap, we define the multi-hop logical reasoning problem on TKGs. With generated three datasets, we propose the first temporal CQE named Temporal Feature-Logic Embedding framework (TFLEX) to answer the temporal complex queries. We utilize vector logic to compute the logic part of Temporal Feature-Logic embeddings, thus naturally modeling all First-Order Logic (FOL) operations on entity set. In addition, our framework extends vector logic on timestamp set to cope with three extra temporal operators (After, Before and Between). Experiments on numerous query patterns demonstrate the effectiveness of our method.
IRAug 3, 2022
Content-Based Landmark Retrieval Combining Global and Local Features using Siamese Neural NetworksTianyi Hu, Monika Kwiatkowski, Simon Matern et al.
In this work, we present a method for landmark retrieval that utilizes global and local features. A Siamese network is used for global feature extraction and metric learning, which gives an initial ranking of the landmark search. We utilize the extracted feature maps from the Siamese architecture as local descriptors, the search results are then further refined using a cosine similarity between local descriptors. We conduct a deeper analysis of the Google Landmark Dataset, which is used for evaluation, and augment the dataset to handle various intra-class variances. Furthermore, we conduct several experiments to compare the effects of transfer learning and metric learning, as well as experiments using other local descriptors. We show that a re-ranking using local features can improve the search results. We believe that the proposed local feature extraction using cosine similarity is a simple approach that can be extended to many other retrieval tasks.
AIMay 23, 2022
FLEX: Feature-Logic Embedding Framework for CompleX Knowledge Graph ReasoningXueyuan Lin, Haihong E, Gengxian Zhou et al.
Current best performing models for knowledge graph reasoning (KGR) introduce geometry objects or probabilistic distributions to embed entities and first-order logical (FOL) queries into low-dimensional vector spaces. They can be summarized as a center-size framework (point/box/cone, Beta/Gaussian distribution, etc.). However, they have limited logical reasoning ability. And it is difficult to generalize to various features, because the center and size are one-to-one constrained, unable to have multiple centers or sizes. To address these challenges, we instead propose a novel KGR framework named Feature-Logic Embedding framework, FLEX, which is the first KGR framework that can not only TRULY handle all FOL operations including conjunction, disjunction, negation and so on, but also support various feature spaces. Specifically, the logic part of feature-logic framework is based on vector logic, which naturally models all FOL operations. Experiments demonstrate that FLEX significantly outperforms existing state-of-the-art methods on benchmark datasets.
CLJan 30Code
DIVERGE: Diversity-Enhanced RAG for Open-Ended Information SeekingTianyi Hu, Niket Tandon, Akhil Arora
Existing retrieval-augmented generation (RAG) systems are primarily designed under the assumption that each query has a single correct answer. This overlooks common information-seeking scenarios with multiple plausible answers, where diversity is essential to avoid collapsing to a single dominant response, thereby constraining creativity and compromising fair and inclusive information access. Our analysis reveals a commonly overlooked limitation of standard RAG systems: they underutilize retrieved context diversity, such that increasing retrieval diversity alone does not yield diverse generations. To address this limitation, we propose DIVERGE, a plug-and-play agentic RAG framework with novel reflection-guided generation and memory-augmented iterative refinement, which promotes diverse viewpoints while preserving answer quality. We introduce novel metrics tailored to evaluating the diversity-quality trade-off in open-ended questions, and show that they correlate well with human judgments. We demonstrate that DIVERGE achieves the best diversity-quality trade-off compared to competitive baselines and previous state-of-the-art methods on the real-world Infinity-Chat dataset, substantially improving diversity while maintaining quality. More broadly, our results reveal a systematic limitation of current LLM-based systems for open-ended information-seeking and show that explicitly modeling diversity can mitigate it. Our code is available at: https://github.com/au-clan/Diverge
LGApr 22Code
CHASM: Unveiling Covert Advertisements on Chinese Social MediaJingyi Zheng, Tianyi Hu, Yule Liu et al.
Current benchmarks for evaluating large language models (LLMs) in social media moderation completely overlook a serious threat: covert advertisements, which disguise themselves as regular posts to deceive and mislead consumers into making purchases, leading to significant ethical and legal concerns. In this paper, we present the CHASM, a first-of-its-kind dataset designed to evaluate the capability of Multimodal Large Language Models (MLLMs) in detecting covert advertisements on social media. CHASM is a high-quality, anonymized, manually curated dataset consisting of 4,992 instances, based on real-world scenarios from the Chinese social media platform Rednote. The dataset was collected and annotated under strict privacy protection and quality control protocols. It includes many product experience sharing posts that closely resemble covert advertisements, making the dataset particularly challenging.The results show that under both zero-shot and in-context learning settings, none of the current MLLMs are sufficiently reliable for detecting covert advertisements.Our further experiments revealed that fine-tuning open-source MLLMs on our dataset yielded noticeable performance gains. However, significant challenges persist, such as detecting subtle cues in comments and differences in visual and textual structures.We provide in-depth error analysis and outline future research directions. We hope our study can serve as a call for the research community and platform moderators to develop more precise defenses against this emerging threat.
AIFeb 6
SeeUPO: Sequence-Level Agentic-RL with Convergence GuaranteesTianyi Hu, Qingxu Fu, Yanxi Chen et al.
Reinforcement learning (RL) has emerged as the predominant paradigm for training large language model (LLM)-based AI agents. However, existing backbone RL algorithms lack verified convergence guarantees in agentic scenarios, especially in multi-turn settings, which can lead to training instability and failure to converge to optimal policies. In this paper, we systematically analyze how different combinations of policy update mechanisms and advantage estimation methods affect convergence properties in single/multi-turn scenarios. We find that REINFORCE with Group Relative Advantage Estimation (GRAE) can converge to the globally optimal under undiscounted conditions, but the combination of PPO & GRAE breaks PPO's original monotonic improvement property. Furthermore, we demonstrate that mainstream backbone RL algorithms cannot simultaneously achieve both critic-free and convergence guarantees in multi-turn scenarios. To address this, we propose SeeUPO (Sequence-level Sequential Update Policy Optimization), a critic-free approach with convergence guarantees for multi-turn interactions. SeeUPO models multi-turn interaction as sequentially executed multi-agent bandit problems. Through turn-by-turn sequential policy updates in reverse execution order, it ensures monotonic improvement and convergence to global optimal solution via backward induction. Experiments on AppWorld and BFCL v4 demonstrate SeeUPO's substantial improvements over existing backbone algorithms: relative gains of 43.3%-54.6% on Qwen3-14B and 24.1%-41.9% on Qwen2.5-14B (averaged across benchmarks), along with superior training stability.
MADec 28, 2025
Heterogeneity in Multi-Agent Reinforcement LearningTianyi Hu, Zhiqiang Pu, Yuan Wang et al.
Heterogeneity is a fundamental property in multi-agent reinforcement learning (MARL), which is closely related not only to the functional differences of agents, but also to policy diversity and environmental interactions. However, the MARL field currently lacks a rigorous definition and deeper understanding of heterogeneity. This paper systematically discusses heterogeneity in MARL from the perspectives of definition, quantification, and utilization. First, based on an agent-level modeling of MARL, we categorize heterogeneity into five types and provide mathematical definitions. Second, we define the concept of heterogeneity distance and propose a practical quantification method. Third, we design a heterogeneity-based multi-agent dynamic parameter sharing algorithm as an example of the application of our methodology. Case studies demonstrate that our method can effectively identify and quantify various types of agent heterogeneity. Experimental results show that the proposed algorithm, compared to other parameter sharing baselines, has better interpretability and stronger adaptability. The proposed methodology will help the MARL community gain a more comprehensive and profound understanding of heterogeneity, and further promote the development of practical algorithms.
LGJan 29
Less Noise, More Voice: Reinforcement Learning for Reasoning via Instruction PurificationYiju Guo, Tianyi Hu, Zexu Sun et al.
Reinforcement Learning with Verifiable Rewards (RLVR) has advanced LLM reasoning, but remains constrained by inefficient exploration under limited rollout budgets, leading to low sampling success and unstable training in complex tasks. We find that many exploration failures arise not from problem difficulty, but from a small number of prompt tokens that introduce interference. Building on this insight, we propose the Less Noise Sampling Framework (LENS), which first prompts by identifying and removing interference tokens. then transfers successful rollouts from the purification process to supervise policy optimization on the original noisy prompts, enabling the model to learn to ignore interference in the real-world, noisy prompting settings. Experimental results show that LENS significantly outperforms GRPO, delivering higher performance and faster convergence, with a 3.88% average gain and over 1.6$\times$ speedup. Our work highlights the critical role of pruning interference tokens in improving rollout efficiency, offering a new perspective for RLVR research.
AIJan 29
JADE: Bridging the Strategic-Operational Gap in Dynamic Agentic RAGYiqun Chen, Erhan Zhang, Tianyi Hu et al.
The evolution of Retrieval-Augmented Generation (RAG) has shifted from static retrieval pipelines to dynamic, agentic workflows where a central planner orchestrates multi-turn reasoning. However, existing paradigms face a critical dichotomy: they either optimize modules jointly within rigid, fixed-graph architectures, or empower dynamic planning while treating executors as frozen, black-box tools. We identify that this \textit{decoupled optimization} creates a ``strategic-operational mismatch,'' where sophisticated planning strategies fail to materialize due to unadapted local executors, often leading to negative performance gains despite increased system complexity. In this paper, we propose \textbf{JADE} (\textbf{J}oint \textbf{A}gentic \textbf{D}ynamic \textbf{E}xecution), a unified framework for the joint optimization of planning and execution within dynamic, multi-turn workflows. By modeling the system as a cooperative multi-agent team unified under a single shared backbone, JADE enables end-to-end learning driven by outcome-based rewards. This approach facilitates \textit{co-adaptation}: the planner learns to operate within the capability boundaries of the executors, while the executors evolve to align with high-level strategic intent. Empirical results demonstrate that JADE transforms disjoint modules into a synergistic system, yielding remarkable performance improvements via joint optimization and enabling a flexible balance between efficiency and effectiveness through dynamic workflow orchestration.
AIOct 17, 2025Code
Taming the Judge: Deconflicting AI Feedback for Stable Reinforcement LearningBoyin Liu, Zhuo Zhang, Sen Huang et al.
Aligning language models using LLM judge feedback offers a scalable alternative to human annotation, yet is plagued by judgment inconsistencies that destabilize reinforcement learning. While prior work has focused on judge accuracy, the critical issue of logical coherence particularly preference cycles has been largely unaddressed. To address this gap, this work introduces an end to end framework to systematically detect and resolve these inconsistencies within the reinforcement learning training loop. Our framework features two core contributions: the Conflict Detection Rate (CDR), a novel metric to quantify judgment conflicts, and Deconflicted Graph Rewards (DGR), a signal-purification framework that eliminates cycles before policy optimization. DGR constructs preference graphs from raw judgments, transforms them into conflict-free Directed Acyclic Graphs (DAGs), and generates a logically coherent reward signal compatible with any policy optimizer. Experiments confirm that our framework significantly improves training stability and model performance over strong baselines, establishing logical consistency as a crucial and now-addressable dimension of AI feedback. The code for our method is available at https://github.com/modelscope/RM-Gallery.
AIMar 20, 2025Code
Unreal-MAP: Unreal-Engine-Based General Platform for Multi-Agent Reinforcement LearningTianyi Hu, Qingxu Fu, Zhiqiang Pu et al.
In this paper, we propose Unreal Multi-Agent Playground (Unreal-MAP), an MARL general platform based on the Unreal-Engine (UE). Unreal-MAP allows users to freely create multi-agent tasks using the vast visual and physical resources available in the UE community, and deploy state-of-the-art (SOTA) MARL algorithms within them. Unreal-MAP is user-friendly in terms of deployment, modification, and visualization, and all its components are open-source. We also develop an experimental framework compatible with algorithms ranging from rule-based to learning-based provided by third-party frameworks. Lastly, we deploy several SOTA algorithms in example tasks developed via Unreal-MAP, and conduct corresponding experimental analyses. We believe Unreal-MAP can play an important role in the MARL field by closely integrating existing algorithms with user-customized tasks, thus advancing the field of MARL.
LGJan 17, 2025
OMoE: Diversifying Mixture of Low-Rank Adaptation by Orthogonal FinetuningJinyuan Feng, Zhiqiang Pu, Tianyi Hu et al.
Building mixture-of-experts (MoE) architecture for Low-rank adaptation (LoRA) is emerging as a potential direction in parameter-efficient fine-tuning (PEFT) for its modular design and remarkable performance. However, simply stacking the number of experts cannot guarantee significant improvement. In this work, we first conduct qualitative analysis to indicate that experts collapse to similar representations in vanilla MoE, limiting the capacity of modular design and computational efficiency. Ulteriorly, Our analysis reveals that the performance of previous MoE variants maybe limited by a lack of diversity among experts. Motivated by these findings, we propose Orthogonal Mixture-of-Experts (OMoE), a resource-efficient MoE variant that trains experts in an orthogonal manner to promote diversity. In OMoE, a Gram-Schmidt process is leveraged to enforce that the experts' representations lie within the Stiefel manifold. By applying orthogonal constraints directly to the architecture, OMoE keeps the learning objective unchanged, without compromising optimality. Our method is simple and alleviates memory bottlenecks, as it incurs minimal experts compared to vanilla MoE models. Experiments on diverse commonsense reasoning benchmarks demonstrate that OMoE can consistently achieve stable and efficient performance improvement when compared with the state-of-the-art methods while significantly reducing the number of required experts.
CRDec 26, 2024
CL-Attack: Textual Backdoor Attacks via Cross-Lingual TriggersJingyi Zheng, Tianyi Hu, Tianshuo Cong et al.
Backdoor attacks significantly compromise the security of large language models by triggering them to output specific and controlled content. Currently, triggers for textual backdoor attacks fall into two categories: fixed-token triggers and sentence-pattern triggers. However, the former are typically easy to identify and filter, while the latter, such as syntax and style, do not apply to all original samples and may lead to semantic shifts. In this paper, inspired by cross-lingual (CL) prompts of LLMs in real-world scenarios, we propose a higher-dimensional trigger method at the paragraph level, namely CL-attack. CL-attack injects the backdoor by using texts with specific structures that incorporate multiple languages, thereby offering greater stealthiness and universality compared to existing backdoor attack techniques. Extensive experiments on different tasks and model architectures demonstrate that CL-attack can achieve nearly 100% attack success rate with a low poisoning rate in both classification and generation tasks. We also empirically show that the CL-attack is more robust against current major defense methods compared to baseline backdoor attacks. Additionally, to mitigate CL-attack, we further develop a new defense called TranslateDefense, which can partially mitigate the impact of CL-attack.
CLMay 28, 2025
Evaluation Hallucination in Multi-Round Incomplete Information Lateral-Driven Reasoning TasksWenhan Dong, Tianyi Hu, Jingyi Zheng et al.
Multi-round incomplete information tasks are crucial for evaluating the lateral thinking capabilities of large language models (LLMs). Currently, research primarily relies on multiple benchmarks and automated evaluation metrics to assess these abilities. However, our study reveals novel insights into the limitations of existing methods, as they often yield misleading results that fail to uncover key issues, such as shortcut-taking behaviors, rigid patterns, and premature task termination. These issues obscure the true reasoning capabilities of LLMs and undermine the reliability of evaluations. To address these limitations, we propose a refined set of evaluation standards, including inspection of reasoning paths, diversified assessment metrics, and comparative analyses with human performance.
LGAug 7, 2025
Will You Be Aware? Eye Tracking-Based Modeling of Situational Awareness in Augmented RealityZhehan Qu, Tianyi Hu, Christian Fronk et al.
Augmented Reality (AR) systems, while enhancing task performance through real-time guidance, pose risks of inducing cognitive tunneling-a hyperfocus on virtual content that compromises situational awareness (SA) in safety-critical scenarios. This paper investigates SA in AR-guided cardiopulmonary resuscitation (CPR), where responders must balance effective compressions with vigilance to unpredictable hazards (e.g., patient vomiting). We developed an AR app on a Magic Leap 2 that overlays real-time CPR feedback (compression depth and rate) and conducted a user study with simulated unexpected incidents (e.g., bleeding) to evaluate SA, in which SA metrics were collected via observation and questionnaires administered during freeze-probe events. Eye tracking analysis revealed that higher SA levels were associated with greater saccadic amplitude and velocity, and with reduced proportion and frequency of fixations on virtual content. To predict SA, we propose FixGraphPool, a graph neural network that structures gaze events (fixations, saccades) into spatiotemporal graphs, effectively capturing dynamic attentional patterns. Our model achieved 83.0% accuracy (F1=81.0%), outperforming feature-based machine learning and state-of-the-art time-series models by leveraging domain knowledge and spatial-temporal information encoded in ET data. These findings demonstrate the potential of eye tracking for SA modeling in AR and highlight its utility in designing AR systems that ensure user safety and situational awareness.
CLSep 16, 2025
Do LLMs Understand Wine Descriptors Across Cultures? A Benchmark for Cultural Adaptations of Wine ReviewsChenye Zou, Xingyue Wen, Tianyi Hu et al.
Recent advances in large language models (LLMs) have opened the door to culture-aware language tasks. We introduce the novel problem of adapting wine reviews across Chinese and English, which goes beyond literal translation by incorporating regional taste preferences and culture-specific flavor descriptors. In a case study on cross-cultural wine review adaptation, we compile the first parallel corpus of professional reviews, containing 8k Chinese and 16k Anglophone reviews. We benchmark both neural-machine-translation baselines and state-of-the-art LLMs with automatic metrics and human evaluation. For the latter, we propose three culture-oriented criteria -- Cultural Proximity, Cultural Neutrality, and Cultural Genuineness -- to assess how naturally a translated review resonates with target-culture readers. Our analysis shows that current models struggle to capture cultural nuances, especially in translating wine descriptions across different cultures. This highlights the challenges and limitations of translation models in handling cultural content.
CLJul 29, 2025
Culinary Crossroads: A RAG Framework for Enhancing Diversity in Cross-Cultural Recipe AdaptationTianyi Hu, Andrea Morales-Garzón, Jingyi Zheng et al.
In cross-cultural recipe adaptation, the goal is not only to ensure cultural appropriateness and retain the original dish's essence, but also to provide diverse options for various dietary needs and preferences. Retrieval Augmented Generation (RAG) is a promising approach, combining the retrieval of real recipes from the target cuisine for cultural adaptability with large language models (LLMs) for relevance. However, it remains unclear whether RAG can generate diverse adaptation results. Our analysis shows that RAG tends to overly rely on a limited portion of the context across generations, failing to produce diverse outputs even when provided with varied contextual inputs. This reveals a key limitation of RAG in creative tasks with multiple valid answers: it fails to leverage contextual diversity for generating varied responses. To address this issue, we propose CARRIAGE, a plug-and-play RAG framework for cross-cultural recipe adaptation that enhances diversity in both retrieval and context organization. To our knowledge, this is the first RAG framework that explicitly aims to generate highly diverse outputs to accommodate multiple user preferences. Our experiments show that CARRIAGE achieves Pareto efficiency in terms of diversity and quality of recipe adaptation compared to closed-book LLMs.
LGMay 23, 2025
CoMoE: Contrastive Representation for Mixture-of-Experts in Parameter-Efficient Fine-tuningJinyuan Feng, Chaopeng Wei, Tenghai Qiu et al.
In parameter-efficient fine-tuning, mixture-of-experts (MoE), which involves specializing functionalities into different experts and sparsely activating them appropriately, has been widely adopted as a promising approach to trade-off between model capacity and computation overhead. However, current MoE variants fall short on heterogeneous datasets, ignoring the fact that experts may learn similar knowledge, resulting in the underutilization of MoE's capacity. In this paper, we propose Contrastive Representation for MoE (CoMoE), a novel method to promote modularization and specialization in MoE, where the experts are trained along with a contrastive objective by sampling from activated and inactivated experts in top-k routing. We demonstrate that such a contrastive objective recovers the mutual-information gap between inputs and the two types of experts. Experiments on several benchmarks and in multi-task settings demonstrate that CoMoE can consistently enhance MoE's capacity and promote modularization among the experts.
MAJan 20, 2024
Measuring Policy Distance for Multi-Agent Reinforcement LearningTianyi Hu, Zhiqiang Pu, Xiaolin Ai et al.
Diversity plays a crucial role in improving the performance of multi-agent reinforcement learning (MARL). Currently, many diversity-based methods have been developed to overcome the drawbacks of excessive parameter sharing in traditional MARL. However, there remains a lack of a general metric to quantify policy differences among agents. Such a metric would not only facilitate the evaluation of the diversity evolution in multi-agent systems, but also provide guidance for the design of diversity-based MARL algorithms. In this paper, we propose the multi-agent policy distance (MAPD), a general tool for measuring policy differences in MARL. By learning the conditional representations of agents' decisions, MAPD can computes the policy distance between any pair of agents. Furthermore, we extend MAPD to a customizable version, which can quantify differences among agent policies on specified aspects. Based on the online deployment of MAPD, we design a multi-agent dynamic parameter sharing (MADPS) algorithm as an example of the MAPD's applications. Extensive experiments demonstrate that our method is effective in measuring differences in agent policies and specific behavioral tendencies. Moreover, in comparison to other methods of parameter sharing, MADPS exhibits superior performance.
LGFeb 21, 2022
Hybrid Learning for Orchestrating Deep Learning Inference in Multi-user Edge-cloud NetworksSina Shahhosseini, Tianyi Hu, Dongjoo Seo et al.
Deep-learning-based intelligent services have become prevalent in cyber-physical applications including smart cities and health-care. Collaborative end-edge-cloud computing for deep learning provides a range of performance and efficiency that can address application requirements through computation offloading. The decision to offload computation is a communication-computation co-optimization problem that varies with both system parameters (e.g., network condition) and workload characteristics (e.g., inputs). Identifying optimal orchestration considering the cross-layer opportunities and requirements in the face of varying system dynamics is a challenging multi-dimensional problem. While Reinforcement Learning (RL) approaches have been proposed earlier, they suffer from a large number of trial-and-errors during the learning process resulting in excessive time and resource consumption. We present a Hybrid Learning orchestration framework that reduces the number of interactions with the system environment by combining model-based and model-free reinforcement learning. Our Deep Learning inference orchestration strategy employs reinforcement learning to find the optimal orchestration policy. Furthermore, we deploy Hybrid Learning (HL) to accelerate the RL learning process and reduce the number of direct samplings. We demonstrate efficacy of our HL strategy through experimental comparison with state-of-the-art RL-based inference orchestration, demonstrating that our HL strategy accelerates the learning process by up to 166.6x.
LGFeb 21, 2022
Online Learning for Orchestration of Inference in Multi-User End-Edge-Cloud NetworksSina Shahhosseini, Dongjoo Seo, Anil Kanduri et al.
Deep-learning-based intelligent services have become prevalent in cyber-physical applications including smart cities and health-care. Deploying deep-learning-based intelligence near the end-user enhances privacy protection, responsiveness, and reliability. Resource-constrained end-devices must be carefully managed in order to meet the latency and energy requirements of computationally-intensive deep learning services. Collaborative end-edge-cloud computing for deep learning provides a range of performance and efficiency that can address application requirements through computation offloading. The decision to offload computation is a communication-computation co-optimization problem that varies with both system parameters (e.g., network condition) and workload characteristics (e.g., inputs). On the other hand, deep learning model optimization provides another source of tradeoff between latency and model accuracy. An end-to-end decision-making solution that considers such computation-communication problem is required to synergistically find the optimal offloading policy and model for deep learning services. To this end, we propose a reinforcement-learning-based computation offloading solution that learns optimal offloading policy considering deep learning model selection techniques to minimize response time while providing sufficient accuracy. We demonstrate the effectiveness of our solution for edge devices in an end-edge-cloud system and evaluate with a real-setup implementation using multiple AWS and ARM core configurations. Our solution provides 35% speedup in the average response time compared to the state-of-the-art with less than 0.9% accuracy reduction, demonstrating the promise of our online learning framework for orchestrating DL inference in end-edge-cloud systems.
IVDec 23, 2021
KFWC: A Knowledge-Driven Deep Learning Model for Fine-grained Classification of Wet-AMDHaihong E, Jiawen He, Tianyi Hu et al.
Automated diagnosis using deep neural networks can help ophthalmologists detect the blinding eye disease wet Age-related Macular Degeneration (AMD). Wet-AMD has two similar subtypes, Neovascular AMD and Polypoidal Choroidal Vessels (PCV). However, due to the difficulty in data collection and the similarity between images, most studies have only achieved the coarse-grained classification of wet-AMD rather than a finer-grained one of wet-AMD subtypes. To solve this issue, in this paper we propose a Knowledge-driven Fine-grained Wet-AMD Classification Model (KFWC), to classify fine-grained diseases with insufficient data. With the introduction of a priori knowledge of 10 lesion signs of input images into the KFWC, we aim to accelerate the KFWC by means of multi-label classification pre-training, to locate the decisive image features in the fine-grained disease classification task and therefore achieve better classification. Simultaneously, the KFWC can also provide good interpretability and effectively alleviate the pressure of data collection and annotation in the field of fine-grained disease classification for wet-AMD. The experiments demonstrate the effectiveness of the KFWC which reaches 99.71% in AU-ROC scores, and its considerable improvements over the data-driven w/o Knowledge and ophthalmologists, with the rates of 6.69% over the strongest baseline and 4.14% over ophthalmologists.