Yi Xu

Zhimiao Yu, Tiancheng Lin, Yi Xu

Improving the feature representation ability is the foundation of many whole slide pathological image (WSIs) tasks. Recent works have achieved great success in pathological-specific self-supervised learning (SSL). However, most of them only focus on learning patch-level representations, thus there is still a gap between pretext and slide-level downstream tasks, e.g., subtyping, grading and staging. Aiming towards slide-level representations, we propose Slide-Level Prototypical Distillation (SLPD) to explore intra- and inter-slide semantic structures for context modeling on WSIs. Specifically, we iteratively perform intra-slide clustering for the regions (4096x4096 patches) within each WSI to yield the prototypes and encourage the region representations to be closer to the assigned prototypes. By representing each slide with its prototypes, we further select similar slides by the set distance of prototypes and assign the regions by cross-slide prototypes for distillation. SLPD achieves state-of-the-art results on multiple slide-level benchmarks and demonstrates that representation learning of semantic structures of slides can make a suitable proxy task for WSI analysis. Code will be available at https://github.com/Carboxy/SLPD.

Zhimiao Yu, Tiancheng Lin, Yi Xu

Recent few-shot segmentation (FSS) methods introduce an extra pre-training stage before meta-training to obtain a stronger backbone, which has become a standard step in few-shot learning. Despite the effectiveness, current pre-training scheme suffers from the merged background problem: only base classes are labelled as foregrounds, making it hard to distinguish between novel classes and actual background. In this paper, we propose a new pre-training scheme for FSS via decoupling the novel classes from background, called Background Clustering Pre-Training (BCPT). Specifically, we adopt online clustering to the pixel embeddings of merged background to explore the underlying semantic structures, bridging the gap between pre-training and adaptation to novel classes. Given the clustering results, we further propose the background mining loss and leverage base classes to guide the clustering process, improving the quality and stability of clustering results. Experiments on PASCAL-5i and COCO-20i show that BCPT yields advanced performance. Code will be available.