Qiang Liu

Yihan Hu, Kun Li, Pingyuan Liang et al.

This paper presents our 2nd place solution for the NuPlan Challenge 2023. Autonomous driving in real-world scenarios is highly complex and uncertain. Achieving safe planning in the complex multimodal scenarios is a highly challenging task. Our approach, Imitation with Spatial-Temporal Heatmap, adopts the learning form of behavior cloning, innovatively predicts the future multimodal states with a heatmap representation, and uses trajectory refinement techniques to ensure final safety. The experiment shows that our method effectively balances the vehicle's progress and safety, generating safe and comfortable trajectories. In the NuPlan competition, we achieved the second highest overall score, while obtained the best scores in the ego progress and comfort metrics.

Ruidong Wu, Ruihan Guo, Rui Wang et al.

Despite the striking success of general protein folding models such as AlphaFold2(AF2, Jumper et al. (2021)), the accurate computational modeling of antibody-antigen complexes remains a challenging task. In this paper, we first analyze AF2's primary loss function, known as the Frame Aligned Point Error (FAPE), and raise a previously overlooked issue that FAPE tends to face gradient vanishing problem on high-rotational-error targets. To address this fundamental limitation, we propose a novel geodesic loss called Frame Aligned Frame Error (FAFE, denoted as F2E to distinguish from FAPE), which enables the model to better optimize both the rotational and translational errors between two frames. We then prove that F2E can be reformulated as a group-aware geodesic loss, which translates the optimization of the residue-to-residue error to optimizing group-to-group geodesic frame distance. By fine-tuning AF2 with our proposed new loss function, we attain a correct rate of 52.3\% (DockQ $>$ 0.23) on an evaluation set and 43.8\% correct rate on a subset with low homology, with substantial improvement over AF2 by 182\% and 100\% respectively.