Woojung Han

Yeonkyung Lee, Woojung Han, Youngjun Jun et al.

Retinal foundation models have significantly advanced retinal image analysis by leveraging self-supervised learning to reduce dependence on labeled data while achieving strong generalization. Many recent approaches enhance retinal image understanding using report supervision, but obtaining clinical reports is often costly and challenging. In contrast, metadata (e.g., age, gender) is widely available and serves as a valuable resource for analyzing disease progression. To effectively incorporate patient-specific information, we propose PRETI, a retinal foundation model that integrates metadata-aware learning with robust self-supervised representation learning. We introduce Learnable Metadata Embedding (LME), which dynamically refines metadata representations. Additionally, we construct patient-level data pairs, associating images from the same individual to improve robustness against non-clinical variations. To further optimize retinal image representation, we propose Retina-Aware Adaptive Masking (RAAM), a strategy that selectively applies masking within the retinal region and dynamically adjusts the masking ratio during training. PRETI captures both global structures and fine-grained pathological details, resulting in superior diagnostic performance. Extensive experiments demonstrate that PRETI achieves state-of-the-art results across diverse diseases and biomarker predictions using in-house and public data, indicating the importance of metadata-guided foundation models in retinal disease analysis. Our code and pretrained model are available at https://github.com/MICV-yonsei/PRETI

Chanyoung Kim, Woojung Han, Dayun Ju et al.

Semantic segmentation has innately relied on extensive pixel-level annotated data, leading to the emergence of unsupervised methodologies. Among them, leveraging self-supervised Vision Transformers for unsupervised semantic segmentation (USS) has been making steady progress with expressive deep features. Yet, for semantically segmenting images with complex objects, a predominant challenge remains: the lack of explicit object-level semantic encoding in patch-level features. This technical limitation often leads to inadequate segmentation of complex objects with diverse structures. To address this gap, we present a novel approach, EAGLE, which emphasizes object-centric representation learning for unsupervised semantic segmentation. Specifically, we introduce EiCue, a spectral technique providing semantic and structural cues through an eigenbasis derived from the semantic similarity matrix of deep image features and color affinity from an image. Further, by incorporating our object-centric contrastive loss with EiCue, we guide our model to learn object-level representations with intra- and inter-image object-feature consistency, thereby enhancing semantic accuracy. Extensive experiments on COCO-Stuff, Cityscapes, and Potsdam-3 datasets demonstrate the state-of-the-art USS results of EAGLE with accurate and consistent semantic segmentation across complex scenes.

Woojung Han, Chanyoung Kim, Dayun Ju et al.

Recent advances in text-conditioned image generation diffusion models have begun paving the way for new opportunities in modern medical domain, in particular, generating Chest X-rays (CXRs) from diagnostic reports. Nonetheless, to further drive the diffusion models to generate CXRs that faithfully reflect the complexity and diversity of real data, it has become evident that a nontrivial learning approach is needed. In light of this, we propose CXRL, a framework motivated by the potential of reinforcement learning (RL). Specifically, we integrate a policy gradient RL approach with well-designed multiple distinctive CXR-domain specific reward models. This approach guides the diffusion denoising trajectory, achieving precise CXR posture and pathological details. Here, considering the complex medical image environment, we present "RL with Comparative Feedback" (RLCF) for the reward mechanism, a human-like comparative evaluation that is known to be more effective and reliable in complex scenarios compared to direct evaluation. Our CXRL framework includes jointly optimizing learnable adaptive condition embeddings (ACE) and the image generator, enabling the model to produce more accurate and higher perceptual CXR quality. Our extensive evaluation of the MIMIC-CXR-JPG dataset demonstrates the effectiveness of our RL-based tuning approach. Consequently, our CXRL generates pathologically realistic CXRs, establishing a new standard for generating CXRs with high fidelity to real-world clinical scenarios.

Woojung Han, Seil Kang, Kyobin Choo et al.

Leveraging semantically precise pseudo masks derived from image-level class knowledge for segmentation, namely image-level Weakly Supervised Semantic Segmentation (WSSS), still remains challenging. While Class Activation Maps (CAMs) using CNNs have steadily been contributing to the success of WSSS, the resulting activation maps often narrowly focus on class-specific parts (e.g., only face of human). On the other hand, recent works based on vision transformers (ViT) have shown promising results based on their self-attention mechanism to capture the semantic parts but fail in capturing complete class-specific details (e.g., entire body parts of human but also with a dog nearby). In this work, we propose Complementary Branch (CoBra), a novel dual branch framework consisting of two distinct architectures which provide valuable complementary knowledge of class (from CNN) and semantic (from ViT) to each branch. In particular, we learn Class-Aware Projection (CAP) for the CNN branch and Semantic-Aware Projection (SAP) for the ViT branch to explicitly fuse their complementary knowledge and facilitate a new type of extra patch-level supervision. Our model, through CoBra, fuses CNN and ViT's complementary outputs to create robust pseudo masks that integrate both class and semantic information effectively. Extensive experiments qualitatively and quantitatively investigate how CNN and ViT complement each other on the PASCAL VOC 2012 dataset, showing a state-of-the-art WSSS result. This includes not only the masks generated by our model, but also the segmentation results derived from utilizing these masks as pseudo labels.

Chanyoung Kim, Dayun Ju, Jinyeong Kim et al.

As recent text-conditioned diffusion models have enabled the generation of high-quality images, concerns over their potential misuse have also grown. This issue is critical in the medical domain, where text-conditioned generated medical images could enable insurance fraud or falsified records, highlighting the urgent need for reliable safeguards against unethical use. While watermarking techniques have emerged as a promising solution in general image domains, their direct application to medical imaging presents significant challenges. A key challenge is preserving fine-grained disease manifestations, as even minor distortions from a watermark may lead to clinical misinterpretation, which compromises diagnostic integrity. To overcome this gap, we present MedSign, a deep learning-based watermarking framework specifically designed for text-to-medical image synthesis, which preserves pathologically significant regions by adaptively adjusting watermark strength. Specifically, we generate a pathology localization map using cross-attention between medical text tokens and the diffusion denoising network, aggregating token-wise attention across layers, heads, and time steps. Leveraging this map, we optimize the LDM decoder to incorporate watermarking during image synthesis, ensuring cohesive integration while minimizing interference in diagnostically critical regions. Experimental results show that our MedSign preserves diagnostic integrity while ensuring watermark robustness, achieving state-of-the-art performance in image quality and detection accuracy on MIMIC-CXR and OIA-ODIR datasets.