Jiarui Zhu

Weixing Chen, Yang Liu, Ce Wang et al.

Radiology Report Generation (RRG) is essential for computer-aided diagnosis and medication guidance, which can relieve the heavy burden of radiologists by automatically generating the corresponding radiology reports according to the given radiology image. However, generating accurate lesion descriptions remains challenging due to spurious correlations from visual-linguistic biases and inherent limitations of radiological imaging, such as low resolution and noise interference. To address these issues, we propose a two-stage framework named CrossModal Causal Representation Learning (CMCRL), consisting of the Radiological Cross-modal Alignment and Reconstruction Enhanced (RadCARE) pre-training and the Visual-Linguistic Causal Intervention (VLCI) fine-tuning. In the pre-training stage, RadCARE introduces a degradation-aware masked image restoration strategy tailored for radiological images, which reconstructs high-resolution patches from low-resolution inputs to mitigate noise and detail loss. Combined with a multiway architecture and four adaptive training strategies (e.g., text postfix generation with degraded images and text prefixes), RadCARE establishes robust cross-modal correlations even with incomplete data. In the VLCI phase, we deploy causal front-door intervention through two modules: the Visual Deconfounding Module (VDM) disentangles local-global features without fine-grained annotations, while the Linguistic Deconfounding Module (LDM) eliminates context bias without external terminology databases. Experiments on IU-Xray and MIMIC-CXR show that our CMCRL pipeline significantly outperforms state-of-the-art methods, with ablation studies confirming the necessity of both stages. Code and models are available at https://github.com/WissingChen/CMCRL.

Jiarui Zhu, Werxing Chen, Hongfei Sun et al.

Cone-beam computed tomography (CBCT) is routinely collected during image-guided radiation therapy (IGRT) to provide updated patient anatomy information for cancer treatments. However, CBCT images often suffer from streaking artifacts and noise caused by under-rate sampling projections and low-dose exposure, resulting in low clarity and information loss. While recent deep learning-based CBCT enhancement methods have shown promising results in suppressing artifacts, they have limited performance on preserving anatomical details since conventional pixel-to-pixel loss functions are incapable of describing detailed anatomy. To address this issue, we propose a novel feature-oriented deep learning framework that translates low-quality CBCT images into high-quality CT-like imaging via a multi-task customized feature-to-feature perceptual loss function. The framework comprises two main components: a multi-task learning feature-selection network(MTFS-Net) for customizing the perceptual loss function; and a CBCT-to-CT translation network guided by feature-to-feature perceptual loss, which uses advanced generative models such as U-Net, GAN and CycleGAN. Our experiments showed that the proposed framework can generate synthesized CT (sCT) images for the lung that achieved a high similarity to CT images, with an average SSIM index of 0.9869 and an average PSNR index of 39.9621. The sCT images also achieved visually pleasing performance with effective artifacts suppression, noise reduction, and distinctive anatomical details preservation. Our experiment results indicate that the proposed framework outperforms the state-of-the-art models for pulmonary CBCT enhancement. This framework holds great promise for generating high-quality anatomical imaging from CBCT that is suitable for various clinical applications.