Martina Descovich

Di Xu, Hengjie Liu, Yang Yang et al.

Accelerated dynamic volumetric magnetic resonance imaging (4DMRI) is essential for applications relying on motion resolution. Existing 4DMRI produces acceptable artifacts of averaged breathing phases, which can blur and misrepresent instantaneous dynamic information. Recovery of such information requires a new paradigm to reconstruct extremely undersampled non-Cartesian k-space data. We propose B-FIRE, a binning-free diffusion implicit neural representation framework for hyper-accelerated MR reconstruction capable of reflecting instantaneous 3D abdominal anatomy. B-FIRE employs a CNN-INR encoder-decoder backbone optimized using diffusion with a comprehensive loss that enforces image-domain fidelity and frequency-aware constraints. Motion binned image pairs were used as training references, while inference was performed on binning-free undersampled data. Experiments were conducted on a T1-weighted StarVIBE liver MRI cohort, with accelerations ranging from 8 spokes per frame (RV8) to RV1. B-FIRE was compared against direct NuFFT, GRASP-CS, and an unrolled CNN method. Reconstruction fidelity, motion trajectory consistency, and inference latency were evaluated.

Di Xu, Yang Yang, Hengjie Liu et al.

Computed tomography (CT) provides high spatial resolution visualization of 3D structures for scientific and clinical applications. Traditional analytical/iterative CT reconstruction algorithms require hundreds of angular data samplings, a condition that may not be met in practice due to physical and mechanical limitations. Sparse view CT reconstruction has been proposed using constrained optimization and machine learning methods with varying success, less so for ultra-sparse view CT reconstruction with one to two views. Neural radiance field (NeRF) is a powerful tool for reconstructing and rendering 3D natural scenes from sparse views, but its direct application to 3D medical image reconstruction has been minimally successful due to the differences between optical and X-ray photon transportation. Here, we develop a novel TomoGRAF framework incorporating the unique X-ray transportation physics to reconstruct high-quality 3D volumes using ultra-sparse projections without prior. TomoGRAF captures the CT imaging geometry, simulates the X-ray casting and tracing process, and penalizes the difference between simulated and ground truth CT sub-volume during training. We evaluated the performance of TomoGRAF on an unseen dataset of distinct imaging characteristics from the training data and demonstrated a vast leap in performance compared with state-of-the-art deep learning and NeRF methods. TomoGRAF provides the first generalizable solution for image-guided radiotherapy and interventional radiology applications, where only one or a few X-ray views are available, but 3D volumetric information is desired.