Yaoyao Zhu

Yaoyao Zhu, Xiuding Cai, Yingkai Wang et al.

Deep learning models excel in computer vision tasks but often fail to generalize to out-of-distribution (OOD) domains. Invariant Risk Minimization (IRM) aims to address OOD generalization by learning domain-invariant features. However, IRM struggles with datasets exhibiting significant diversity shifts. While data augmentation methods like Mixup and Semantic Data Augmentation (SDA) enhance diversity, they risk over-augmentation and label instability. To address these challenges, we propose a domain-shared Semantic Data Augmentation (SDA) module, a novel implementation of Variance Risk Minimization (VRM) designed to enhance dataset diversity while maintaining label consistency. We further provide a Rademacher complexity analysis, establishing a tighter generalization error bound compared to baseline methods. Extensive evaluations on OOD benchmarks, including PACS, VLCS, OfficeHome, and TerraIncognita, demonstrate consistent performance improvements over state-of-the-art domain generalization methods.

Yingkai Wang, Yaoyao Zhu, Xiuding Cai et al.

Medical image segmentation plays a crucial role in clinical workflows, but domain shift often leads to performance degradation when models are applied to unseen clinical domains. This challenge arises due to variations in imaging conditions, scanner types, and acquisition protocols, limiting the practical deployment of segmentation models. Unlike natural images, medical images typically exhibit consistent anatomical structures across patients, with domain-specific variations mainly caused by imaging conditions. This unique characteristic makes medical image segmentation particularly challenging. To address this challenge, we propose a domain generalization framework tailored for medical image segmentation. Our approach improves robustness to domain-specific variations by introducing implicit feature perturbations guided by domain statistics. Specifically, we employ a learnable semantic direction selector and a covariance-based semantic intensity sampler to modulate domain-variant features while preserving task-relevant anatomical consistency. Furthermore, we design an adaptive consistency constraint that is selectively applied only when feature adjustment leads to degraded segmentation performance. This constraint encourages the adjusted features to align with the original predictions, thereby stabilizing feature selection and improving the reliability of the segmentation. Extensive experiments on two public multi-center benchmarks show that our framework consistently outperforms existing domain generalization approaches, achieving robust and generalizable segmentation performance across diverse clinical domains.

Yaoyao Zhu, Xiuding Cai, Yingkai Wang et al.

Deep learning has achieved remarkable success in medical image classification. However, its clinical application is often hindered by data heterogeneity caused by variations in scanner vendors, imaging protocols, and operators. Approaches such as invariant risk minimization (IRM) aim to address this challenge of out-of-distribution generalization. For instance, VIRM improves upon IRM by tackling the issue of insufficient feature support overlap, demonstrating promising potential. Nonetheless, these methods face limitations in medical imaging due to the scarcity of annotated data and the inefficiency of augmentation strategies. To address these issues, we propose a novel domain-oriented direction selector to replace the random augmentation strategy used in VIRM. Our method leverages inter-domain covariance as a guider for augmentation direction, guiding data augmentation towards the target domain. This approach effectively reduces domain discrepancies and enhances generalization performance. Experiments on a multi-center diabetic retinopathy dataset demonstrate that our method outperforms state-of-the-art approaches, particularly under limited data conditions and significant domain heterogeneity.