Mingyao Li

Yinuo Xu, Yan Cui, Mingyao Li et al.

Identifying cell types and subtypes in routine histopathology is fundamental for understanding disease. Existing tile-based models capture nuclear detail but miss the broader tissue context that influences cell identity. Current human annotations are coarse-grained and uneven across studies, making fine-grained, subtype-level classification difficult. In this study, we build a marker-guided dataset from Xenium spatial transcriptomics with single-cell resolution labels for more than two million cells across eight organs and 16 classes to address the lack of high-quality annotations. Leveraging this data resource, we introduce NuClass, a pathologist workflow inspired framework for cell-wise multi-scale integration of nuclear morphology and microenvironmental context. It combines Path local, which focuses on nuclear morphology from 224x224 pixel crops, and Path global, which models the surrounding 1024x1024 pixel neighborhood, through a learnable gating module that balances local and global information. An uncertainty-guided objective directs the global path to prioritize regions where the local path is uncertain, and we provide calibrated confidence estimates and Grad-CAM maps for interpretability. Evaluated on three fully held-out cohorts, NuClass achieves up to 96 percent F1 for its best-performing class, outperforming strong baselines. Our results demonstrate that multi-scale, uncertainty-aware fusion can bridge the gap between slide-level pathological foundation models and reliable, cell-level phenotype prediction.

Chang-You Tai, Ming-Yao Li, Lun-Wei Ku

Automatic identification of salient aspects from user reviews is especially useful for opinion analysis. There has been significant progress in utilizing weakly supervised approaches, which require only a small set of seed words for training aspect classifiers. However, there is always room for improvement. First, no weakly supervised approaches fully utilize latent hierarchies between words. Second, each seed words representation should have different latent semantics and be distinct when it represents a different aspect. In this paper, we propose HDAE, a hyperbolic disentangled aspect extractor in which a hyperbolic aspect classifier captures words latent hierarchies, and aspect-disentangled representation models the distinct latent semantics of each seed word. Compared to previous baselines, HDAE achieves average F1 performance gains of 18.2% and 24.1% on Amazon product review and restaurant review datasets, respectively. In addition, the em-bedding visualization experience demonstrates that HDAE is a more effective approach to leveraging seed words. An ablation study and a case study further attest to the effectiveness of the proposed components