Sonja Greven

Marco Simnacher, Xiangnan Xu, Hani Park et al.

Conditional independence tests (CITs) test for conditional dependence between random variables. As existing CITs are limited in their applicability to complex, high-dimensional variables such as images, we introduce deep nonparametric CITs (DNCITs). The DNCITs combine embedding maps, which extract feature representations of high-dimensional variables, with nonparametric CITs applicable to these feature representations. For the embedding maps, we derive general properties on their parameter estimators to obtain valid DNCITs and show that these properties include embedding maps learned through (conditional) unsupervised or transfer learning. For the nonparametric CITs, appropriate tests are selected and adapted to be applicable to feature representations. Through simulations, we investigate the performance of the DNCITs for different embedding maps and nonparametric CITs under varying confounder dimensions and confounder relationships. We apply the DNCITs to brain MRI scans and behavioral traits, given confounders, of healthy individuals from the UK Biobank (UKB), confirming null results from a number of ambiguous personality neuroscience studies with a larger data set and with our more powerful tests. In addition, in a confounder control study, we apply the DNCITs to brain MRI scans and a confounder set to test for sufficient confounder control, leading to a potential reduction in the confounder dimension under improved confounder control compared to existing state-of-the-art confounder control studies for the UKB. Finally, we provide an R package implementing the DNCITs.

Vanessa Emanuela Guarino, Claudia Winklmayr, Jannik Franzen et al.

Uncertainty Quantification (UQ) is crucial for ensuring the reliability of automated image segmentations in safety-critical domains like biomedical image analysis or autonomous driving. In segmentation, UQ generates pixel-wise uncertainty scores that must be aggregated into image-level scores for downstream tasks like Out-of-Distribution (OoD) or failure detection. Despite routine use of aggregation strategies, their properties and impact on downstream task performance have not yet been comprehensively studied. Global Average is the default choice, yet it does not account for spatial and structural features of segmentation uncertainty. Alternatives like patch-, class- and threshold-based strategies exist, but lack systematic comparison, leading to inconsistent reporting and unclear best practices. We address this gap by (1) formally analyzing properties, limitations, and pitfalls of common strategies; (2) proposing novel strategies that incorporate spatial uncertainty structure and (3) benchmarking their performance on OoD and failure detection across ten datasets that vary in image geometry and structure. We find that aggregators leveraging spatial structure yield stronger performance in both downstream tasks studied. However, the performance of individual aggregators depends heavily on dataset characteristics, so we (4) propose a meta-aggregator that integrates multiple aggregators and performs robustly across datasets.

Almond Stöcker, Lisa Steyer, Sonja Greven

The "shape" of a planar curve and/or landmark configuration is considered its equivalence class under translation, rotation and scaling, its "form" its equivalence class under translation and rotation while scale is preserved. We extend generalized additive regression to models for such shapes/forms as responses respecting the resulting quotient geometry by employing the squared geodesic distance as loss function and a geodesic response function to map the additive predictor to the shape/form space. For fitting the model, we propose a Riemannian $L_2$-Boosting algorithm well suited for a potentially large number of possibly parameter-intensive model terms, which also yields automated model selection. We provide novel intuitively interpretable visualizations for (even non-linear) covariate effects in the shape/form space via suitable tensor-product factorization. The usefulness of the proposed framework is illustrated in an analysis of 1) astragalus shapes of wild and domesticated sheep and 2) cell forms generated in a biophysical model, as well as 3) in a realistic simulation study with response shapes and forms motivated from a dataset on bottle outlines.

Amanda Fernández-Fontelo, Pascal J. Kieslich, Felix Henninger et al.

A central goal of survey research is to collect robust and reliable data from respondents. However, despite researchers' best efforts in designing questionnaires, respondents may experience difficulty understanding questions' intent and therefore may struggle to respond appropriately. If it were possible to detect such difficulty, this knowledge could be used to inform real-time interventions through responsive questionnaire design, or to indicate and correct measurement error after the fact. Previous research in the context of web surveys has used paradata, specifically response times, to detect difficulties and to help improve user experience and data quality. However, richer data sources are now available, in the form of the movements respondents make with the mouse, as an additional and far more detailed indicator for the respondent-survey interaction. This paper uses machine learning techniques to explore the predictive value of mouse-tracking data with regard to respondents' difficulty. We use data from a survey on respondents' employment history and demographic information, in which we experimentally manipulate the difficulty of several questions. Using features derived from the cursor movements, we predict whether respondents answered the easy or difficult version of a question, using and comparing several state-of-the-art supervised learning methods. In addition, we develop a personalization method that adjusts for respondents' baseline mouse behavior and evaluate its performance. For all three manipulated survey questions, we find that including the full set of mouse movement features improved prediction performance over response-time-only models in nested cross-validation. Accounting for individual differences in mouse movements led to further improvements.

David Rügamer, Sonja Greven

We propose a statistical inference framework for the component-wise functional gradient descent algorithm (CFGD) under normality assumption for model errors, also known as $L_2$-Boosting. The CFGD is one of the most versatile tools to analyze data, because it scales well to high-dimensional data sets, allows for a very flexible definition of additive regression models and incorporates inbuilt variable selection. Due to the variable selection, we build on recent proposals for post-selection inference. However, the iterative nature of component-wise boosting, which can repeatedly select the same component to update, necessitates adaptations and extensions to existing approaches. We propose tests and confidence intervals for linear, grouped and penalized additive model components selected by $L_2$-Boosting. Our concepts also transfer to slow-learning algorithms more generally, and to other selection techniques which restrict the response space to more complex sets than polyhedra. We apply our framework to an additive model for sales prices of residential apartments and investigate the properties of our concepts in simulation studies.

David Rügamer, Sarah Brockhaus, Kornelia Gentsch et al.

The link between different psychophysiological measures during emotion episodes is not well understood. To analyse the functional relationship between electroencephalography (EEG) and facial electromyography (EMG), we apply historical function-on-function regression models to EEG and EMG data that were simultaneously recorded from 24 participants while they were playing a computerised gambling task. Given the complexity of the data structure for this application, we extend simple functional historical models to models including random historical effects, factor-specific historical effects, and factor-specific random historical effects. Estimation is conducted by a component-wise gradient boosting algorithm, which scales well to large data sets and complex models.