Wenhua Liang

Wenhao Chi, Haiping Liu, Hongqiao Dong et al.

In the field of non-invasive medical imaging, radiomic features are utilized to measure tumor characteristics. However, these features can be affected by the techniques used to discretize the images, ultimately impacting the accuracy of diagnosis. To investigate the influence of various image discretization methods on diagnosis, it is common practice to evaluate multiple discretization strategies individually. This approach often leads to redundant and time-consuming tasks such as training predictive models and fine-tuning hyperparameters separately. This study examines the feasibility of employing multi-task Bayesian optimization to accelerate the hyperparameters search for classifying benign and malignant pulmonary nodules using RBF SVM. Our findings suggest that multi-task Bayesian optimization significantly accelerates the search for hyperparameters in comparison to a single-task approach. To the best of our knowledge, this is the first investigation to utilize multi-task Bayesian optimization in a critical medical context.

Lin Shi, Chiyu Ma, Wenhua Liang et al.

LLM-as-a-Judge has emerged as a promising alternative to human evaluators across various tasks, yet inherent biases - particularly position bias, the tendency to favor solutions based on their position within the prompt - compromise its reliability. This exploratory study evaluates position bias in LLM judges across pairwise and list-wise comparison settings, introducing three metrics: repetition stability, position consistency, and preference fairness. Our experiments, involving 15 LLM judges across MTBench and DevBench with 22 tasks and approximately 40 solution-generating models, result in over 150,000 evaluation instances. We identify Judge-Level, Candidate-Level, and Task-Level factors contributing to bias. The findings confirm that position bias is not due to random chance and varies significantly across judges and tasks. While position bias is weakly influenced by the length of prompt components, it is strongly affected by the quality gap between solutions. Our agreement and disagreement analysis among judges further provides insights into the distribution of judging difficulty across the dataset, and highlights the potential for dataset modifications.

Bo Liu, Wenhao Chi, Xinran Li et al.

Lung cancer is the commonest cause of cancer deaths worldwide, and its mortality can be reduced significantly by performing early diagnosis and screening. Since the 1960s, driven by the pressing needs to accurately and effectively interpret the massive volume of chest images generated daily, computer-assisted diagnosis of pulmonary nodule has opened up new opportunities to relax the limitation from physicians' subjectivity, experiences and fatigue. And the fair access to the reliable and affordable computer-assisted diagnosis will fight the inequalities in incidence and mortality between populations. It has been witnessed that significant and remarkable advances have been achieved since the 1980s, and consistent endeavors have been exerted to deal with the grand challenges on how to accurately detect the pulmonary nodules with high sensitivity at low false-positives rate as well as on how to precisely differentiate between benign and malignant nodules. There is a lack of comprehensive examination of the techniques' development which is evolving the pulmonary nodules diagnosis from classical approaches to machine learning-assisted decision support. The main goal of this investigation is to provide a comprehensive state-of-the-art review of the computer-assisted nodules detection and benign-malignant classification techniques developed over 3 decades, which have evolved from the complicated ad hoc analysis pipeline of conventional approaches to the simplified seamlessly integrated deep learning techniques. This review also identifies challenges and highlights opportunities for future work in learning models, learning algorithms and enhancement schemes for bridging current state to future prospect and satisfying future demand.