Zhiqiang Hu

CL
h-index22
26papers
3,975citations
Novelty47%
AI Score36

26 Papers

19.5CVMar 10, 2023Code
Adaptive Supervised PatchNCE Loss for Learning H&E-to-IHC Stain Translation with Inconsistent Groundtruth Image Pairs

Fangda Li, Zhiqiang Hu, Wen Chen et al.

Immunohistochemical (IHC) staining highlights the molecular information critical to diagnostics in tissue samples. However, compared to H&E staining, IHC staining can be much more expensive in terms of both labor and the laboratory equipment required. This motivates recent research that demonstrates that the correlations between the morphological information present in the H&E-stained slides and the molecular information in the IHC-stained slides can be used for H&E-to-IHC stain translation. However, due to a lack of pixel-perfect H&E-IHC groundtruth pairs, most existing methods have resorted to relying on expert annotations. To remedy this situation, we present a new loss function, Adaptive Supervised PatchNCE (ASP), to directly deal with the input to target inconsistencies in a proposed H&E-to-IHC image-to-image translation framework. The ASP loss is built upon a patch-based contrastive learning criterion, named Supervised PatchNCE (SP), and augments it further with weight scheduling to mitigate the negative impact of noisy supervision. Lastly, we introduce the Multi-IHC Stain Translation (MIST) dataset, which contains aligned H&E-IHC patches for 4 different IHC stains critical to breast cancer diagnosis. In our experiment, we demonstrate that our proposed method outperforms existing image-to-image translation methods for stain translation to multiple IHC stains. All of our code and datasets are available at https://github.com/lifangda01/AdaptiveSupervisedPatchNCE.

33.1CLApr 4, 2023Code
LLM-Adapters: An Adapter Family for Parameter-Efficient Fine-Tuning of Large Language Models

Zhiqiang Hu, Lei Wang, Yihuai Lan et al.

The success of large language models (LLMs), like GPT-4 and ChatGPT, has led to the development of numerous cost-effective and accessible alternatives that are created by finetuning open-access LLMs with task-specific data (e.g., ChatDoctor) or instruction data (e.g., Alpaca). Among the various fine-tuning methods, adapter-based parameter-efficient fine-tuning (PEFT) is undoubtedly one of the most attractive topics, as it only requires fine-tuning a few external parameters instead of the entire LLMs while achieving comparable or even better performance. To enable further research on PEFT methods of LLMs, this paper presents LLM-Adapters, an easy-to-use framework that integrates various adapters into LLMs and can execute these adapter-based PEFT methods of LLMs for different tasks. The framework includes state-of-the-art open-access LLMs such as LLaMA, BLOOM, and GPT-J, as well as widely used adapters such as Series adapters, Parallel adapter, Prompt-based learning and Reparametrization-based methods. Moreover, we conduct extensive empirical studies on the impact of adapter types, placement locations, and hyper-parameters to the best design for each adapter-based methods. We evaluate the effectiveness of the adapters on fourteen datasets from two different reasoning tasks, Arithmetic Reasoning and Commonsense Reasoning. The results demonstrate that using adapter-based PEFT in smaller-scale LLMs (7B) with few extra trainable parameters yields comparable, and in some cases superior, performance to powerful LLMs (175B) in zero-shot inference on both reasoning tasks.

1.4CLOct 24, 2022
Are Current Task-oriented Dialogue Systems Able to Satisfy Impolite Users?

Zhiqiang Hu, Roy Kaa-Wei Lee, Nancy F. Chen

Task-oriented dialogue (TOD) systems have assisted users on many tasks, including ticket booking and service inquiries. While existing TOD systems have shown promising performance in serving customer needs, these systems mostly assume that users would interact with the dialogue agent politely. This assumption is unrealistic as impatient or frustrated customers may also interact with TOD systems impolitely. This paper aims to address this research gap by investigating impolite users' effects on TOD systems. Specifically, we constructed an impolite dialogue corpus and conducted extensive experiments to evaluate the state-of-the-art TOD systems on our impolite dialogue corpus. Our experimental results show that existing TOD systems are unable to handle impolite user utterances. We also present a data augmentation method to improve TOD performance in impolite dialogues. Nevertheless, handling impolite dialogues remains a very challenging research task. We hope by releasing the impolite dialogue corpus and establishing the benchmark evaluations, more researchers are encouraged to investigate this new challenging research task.

22.1CLOct 12, 2023
Who Wrote it and Why? Prompting Large-Language Models for Authorship Verification

Chia-Yu Hung, Zhiqiang Hu, Yujia Hu et al.

Authorship verification (AV) is a fundamental task in natural language processing (NLP) and computational linguistics, with applications in forensic analysis, plagiarism detection, and identification of deceptive content. Existing AV techniques, including traditional stylometric and deep learning approaches, face limitations in terms of data requirements and lack of explainability. To address these limitations, this paper proposes PromptAV, a novel technique that leverages Large-Language Models (LLMs) for AV by providing step-by-step stylometric explanation prompts. PromptAV outperforms state-of-the-art baselines, operates effectively with limited training data, and enhances interpretability through intuitive explanations, showcasing its potential as an effective and interpretable solution for the AV task.

4.8CLJul 16, 2024Code
InstructAV: Instruction Fine-tuning Large Language Models for Authorship Verification

Yujia Hu, Zhiqiang Hu, Chun-Wei Seah et al.

Large Language Models (LLMs) have demonstrated remarkable proficiency in a wide range of NLP tasks. However, when it comes to authorship verification (AV) tasks, which involve determining whether two given texts share the same authorship, even advanced models like ChatGPT exhibit notable limitations. This paper introduces a novel approach, termed InstructAV, for authorship verification. This approach utilizes LLMs in conjunction with a parameter-efficient fine-tuning (PEFT) method to simultaneously improve accuracy and explainability. The distinctiveness of InstructAV lies in its ability to align classification decisions with transparent and understandable explanations, representing a significant progression in the field of authorship verification. Through comprehensive experiments conducted across various datasets, InstructAV demonstrates its state-of-the-art performance on the AV task, offering high classification accuracy coupled with enhanced explanation reliability.

8.7CVFeb 28, 2024Code
All in an Aggregated Image for In-Image Learning

Lei Wang, Wanyu Xu, Zhiqiang Hu et al.

This paper introduces a new in-context learning (ICL) mechanism called In-Image Learning (I$^2$L) that combines demonstration examples, visual cues, and chain-of-thought reasoning into an aggregated image to enhance the capabilities of Large Multimodal Models (e.g., GPT-4V) in multimodal reasoning tasks. Unlike previous approaches that rely on converting images to text or incorporating visual input into language models, I$^2$L consolidates all information into an aggregated image and leverages image processing, understanding, and reasoning abilities. This has several advantages: it reduces inaccurate textual descriptions of complex images, provides flexibility in positioning demonstration examples, and avoids multiple input images and lengthy prompts. We also introduce I$^2$L-Hybrid, a method that combines the strengths of I$^2$L with other ICL methods. Specifically, it uses an automatic strategy to select the most suitable method (I$^2$L or another certain ICL method) for a specific task instance. We conduct extensive experiments to assess the effectiveness of I$^2$L and I$^2$L-Hybrid on MathVista, which covers a variety of complex multimodal reasoning tasks. Additionally, we investigate the influence of image resolution, the number of demonstration examples in a single image, and the positions of these demonstrations in the aggregated image on the effectiveness of I$^2$L. Our code is publicly available at https://github.com/AGI-Edgerunners/IIL.

1.5CVSep 13, 2023
Dynamic Spectrum Mixer for Visual Recognition

Zhiqiang Hu, Tao Yu

Recently, MLP-based vision backbones have achieved promising performance in several visual recognition tasks. However, the existing MLP-based methods directly aggregate tokens with static weights, leaving the adaptability to different images untouched. Moreover, Recent research demonstrates that MLP-Transformer is great at creating long-range dependencies but ineffective at catching high frequencies that primarily transmit local information, which prevents it from applying to the downstream dense prediction tasks, such as semantic segmentation. To address these challenges, we propose a content-adaptive yet computationally efficient structure, dubbed Dynamic Spectrum Mixer (DSM). The DSM represents token interactions in the frequency domain by employing the Discrete Cosine Transform, which can learn long-term spatial dependencies with log-linear complexity. Furthermore, a dynamic spectrum weight generation layer is proposed as the spectrum bands selector, which could emphasize the informative frequency bands while diminishing others. To this end, the technique can efficiently learn detailed features from visual input that contains both high- and low-frequency information. Extensive experiments show that DSM is a powerful and adaptable backbone for a range of visual recognition tasks. Particularly, DSM outperforms previous transformer-based and MLP-based models, on image classification, object detection, and semantic segmentation tasks, such as 83.8 \% top-1 accuracy on ImageNet, and 49.9 \% mIoU on ADE20K.

29.6CLJun 25, 2024Code
Math-LLaVA: Bootstrapping Mathematical Reasoning for Multimodal Large Language Models

Wenhao Shi, Zhiqiang Hu, Yi Bin et al.

Large language models (LLMs) have demonstrated impressive reasoning capabilities, particularly in textual mathematical problem-solving. However, existing open-source image instruction fine-tuning datasets, containing limited question-answer pairs per image, do not fully exploit visual information to enhance the multimodal mathematical reasoning capabilities of Multimodal LLMs (MLLMs). To bridge this gap, we address the lack of high-quality, diverse multimodal mathematical datasets by collecting 40K high-quality images with question-answer pairs from 24 existing datasets and synthesizing 320K new pairs, creating the MathV360K dataset, which enhances both the breadth and depth of multimodal mathematical questions. We introduce Math-LLaVA, a LLaVA-1.5-based model fine-tuned with MathV360K. This novel approach significantly improves the multimodal mathematical reasoning capabilities of LLaVA-1.5, achieving a 19-point increase and comparable performance to GPT-4V on MathVista's minitest split, and yielding leading performance on Math-V and MathVerse. Furthermore, Math-LLaVA demonstrates enhanced generalizability, showing substantial improvements on the MMMU benchmark. Our research highlights the importance of dataset diversity and synthesis in advancing MLLMs' mathematical reasoning abilities. The code and data are available at: \url{https://github.com/HZQ950419/Math-LLaVA}.

10.4IVMay 23, 2023Code
A Laplacian Pyramid Based Generative H&E Stain Augmentation Network

Fangda Li, Zhiqiang Hu, Wen Chen et al.

Hematoxylin and Eosin (H&E) staining is a widely used sample preparation procedure for enhancing the saturation of tissue sections and the contrast between nuclei and cytoplasm in histology images for medical diagnostics. However, various factors, such as the differences in the reagents used, result in high variability in the colors of the stains actually recorded. This variability poses a challenge in achieving generalization for machine-learning based computer-aided diagnostic tools. To desensitize the learned models to stain variations, we propose the Generative Stain Augmentation Network (G-SAN) -- a GAN-based framework that augments a collection of cell images with simulated yet realistic stain variations. At its core, G-SAN uses a novel and highly computationally efficient Laplacian Pyramid (LP) based generator architecture, that is capable of disentangling stain from cell morphology. Through the task of patch classification and nucleus segmentation, we show that using G-SAN-augmented training data provides on average 15.7% improvement in F1 score and 7.3% improvement in panoptic quality, respectively. Our code is available at https://github.com/lifangda01/GSAN-Demo.

38.9CLMay 6, 2023Code
Plan-and-Solve Prompting: Improving Zero-Shot Chain-of-Thought Reasoning by Large Language Models

Lei Wang, Wanyu Xu, Yihuai Lan et al.

Large language models (LLMs) have recently been shown to deliver impressive performance in various NLP tasks. To tackle multi-step reasoning tasks, few-shot chain-of-thought (CoT) prompting includes a few manually crafted step-by-step reasoning demonstrations which enable LLMs to explicitly generate reasoning steps and improve their reasoning task accuracy. To eliminate the manual effort, Zero-shot-CoT concatenates the target problem statement with "Let's think step by step" as an input prompt to LLMs. Despite the success of Zero-shot-CoT, it still suffers from three pitfalls: calculation errors, missing-step errors, and semantic misunderstanding errors. To address the missing-step errors, we propose Plan-and-Solve (PS) Prompting. It consists of two components: first, devising a plan to divide the entire task into smaller subtasks, and then carrying out the subtasks according to the plan. To address the calculation errors and improve the quality of generated reasoning steps, we extend PS prompting with more detailed instructions and derive PS+ prompting. We evaluate our proposed prompting strategy on ten datasets across three reasoning problems. The experimental results over GPT-3 show that our proposed zero-shot prompting consistently outperforms Zero-shot-CoT across all datasets by a large margin, is comparable to or exceeds Zero-shot-Program-of-Thought Prompting, and has comparable performance with 8-shot CoT prompting on the math reasoning problem. The code can be found at https://github.com/AGI-Edgerunners/Plan-and-Solve-Prompting.

9.4CVJul 8, 2021Code
Multi-frame Collaboration for Effective Endoscopic Video Polyp Detection via Spatial-Temporal Feature Transformation

Lingyun Wu, Zhiqiang Hu, Yuanfeng Ji et al.

Precise localization of polyp is crucial for early cancer screening in gastrointestinal endoscopy. Videos given by endoscopy bring both richer contextual information as well as more challenges than still images. The camera-moving situation, instead of the common camera-fixed-object-moving one, leads to significant background variation between frames. Severe internal artifacts (e.g. water flow in the human body, specular reflection by tissues) can make the quality of adjacent frames vary considerately. These factors hinder a video-based model to effectively aggregate features from neighborhood frames and give better predictions. In this paper, we present Spatial-Temporal Feature Transformation (STFT), a multi-frame collaborative framework to address these issues. Spatially, STFT mitigates inter-frame variations in the camera-moving situation with feature alignment by proposal-guided deformable convolutions. Temporally, STFT proposes a channel-aware attention module to simultaneously estimate the quality and correlation of adjacent frames for adaptive feature aggregation. Empirical studies and superior results demonstrate the effectiveness and stability of our method. For example, STFT improves the still image baseline FCOS by 10.6% and 20.6% on the comprehensive F1-score of the polyp localization task in CVC-Clinic and ASUMayo datasets, respectively, and outperforms the state-of-the-art video-based method by 3.6% and 8.0%, respectively. Code is available at \url{https://github.com/lingyunwu14/STFT}.

21.2CLMay 10, 2023
Adapter-TST: A Parameter Efficient Method for Multiple-Attribute Text Style Transfer

Zhiqiang Hu, Roy Ka-Wei Lee, Nancy F. Chen

Adapting a large language model for multiple-attribute text style transfer via fine-tuning can be challenging due to the significant amount of computational resources and labeled data required for the specific task. In this paper, we address this challenge by introducing AdapterTST, a framework that freezes the pre-trained model's original parameters and enables the development of a multiple-attribute text style transfer model. Using BART as the backbone model, Adapter-TST utilizes different neural adapters to capture different attribute information, like a plug-in connected to BART. Our method allows control over multiple attributes, like sentiment, tense, voice, etc., and configures the adapters' architecture to generate multiple outputs respected to attributes or compositional editing on the same sentence. We evaluate the proposed model on both traditional sentiment transfer and multiple-attribute transfer tasks. The experiment results demonstrate that Adapter-TST outperforms all the state-of-the-art baselines with significantly lesser computational resources. We have also empirically shown that each adapter is able to capture specific stylistic attributes effectively and can be configured to perform compositional editing.

2.6CVJan 21, 2022Code
Contrastive and Selective Hidden Embeddings for Medical Image Segmentation

Zhuowei Li, Zihao Liu, Zhiqiang Hu et al.

Medical image segmentation has been widely recognized as a pivot procedure for clinical diagnosis, analysis, and treatment planning. However, the laborious and expensive annotation process lags down the speed of further advances. Contrastive learning-based weight pre-training provides an alternative by leveraging unlabeled data to learn a good representation. In this paper, we investigate how contrastive learning benefits the general supervised medical segmentation tasks. To this end, patch-dragsaw contrastive regularization (PDCR) is proposed to perform patch-level tugging and repulsing with the extent controlled by a continuous affinity score. And a new structure dubbed uncertainty-aware feature selection block (UAFS) is designed to perform the feature selection process, which can handle the learning target shift caused by minority features with high uncertainty. By plugging the proposed 2 modules into the existing segmentation architecture, we achieve state-of-the-art results across 8 public datasets from 6 domains. Newly designed modules further decrease the amount of training data to a quarter while achieving comparable, if not better, performances. From this perspective, we take the opposite direction of the original self/un-supervised contrastive learning by further excavating information contained within the label.

30.7CLSep 15, 2021
Improving Text Auto-Completion with Next Phrase Prediction

Dong-Ho Lee, Zhiqiang Hu, Roy Ka-Wei Lee

Language models such as GPT-2 have performed well on constructing syntactically sound sentences for text auto-completion task. However, such models often require considerable training effort to adapt to specific writing domains (e.g., medical). In this paper, we propose an intermediate training strategy to enhance pre-trained language models' performance in the text auto-completion task and fastly adapt them to specific domains. Our strategy includes a novel self-supervised training objective called Next Phrase Prediction (NPP), which encourages a language model to complete the partial query with enriched phrases and eventually improve the model's text auto-completion performance. Preliminary experiments have shown that our approach is able to outperform the baselines in auto-completion for email and academic writing domains.

30.6CLAug 12, 2021
Syntax Matters! Syntax-Controlled in Text Style Transfer

Zhiqiang Hu, Roy Ka-Wei Lee, Charu C. Aggarwal

Existing text style transfer (TST) methods rely on style classifiers to disentangle the text's content and style attributes for text style transfer. While the style classifier plays a critical role in existing TST methods, there is no known investigation on its effect on the TST methods. In this paper, we conduct an empirical study on the limitations of the style classifiers used in existing TST methods. We demonstrate that the existing style classifiers cannot learn sentence syntax effectively and ultimately worsen existing TST models' performance. To address this issue, we propose a novel Syntax-Aware Controllable Generation (SACG) model, which includes a syntax-aware style classifier that ensures learned style latent representations effectively capture the syntax information for TST. Through extensive experiments on two popular TST tasks, we show that our proposed method significantly outperforms the state-of-the-art methods. Our case studies have also demonstrated SACG's ability to generate fluent target-style sentences that preserved the original content.

6.5CVJul 2, 2021
Hybrid Supervision Learning for Pathology Whole Slide Image Classification

Jiahui Li, Wen Chen, Xiaodi Huang et al.

Weak supervision learning on classification labels has demonstrated high performance in various tasks, while a few pixel-level fine annotations are also affordable. Naturally a question comes to us that whether the combination of pixel-level (e.g., segmentation) and image level (e.g., classification) annotation can introduce further improvement. However in computational pathology this is a difficult task for this reason: High resolution of whole slide images makes it difficult to do end-to-end classification model training, which is challenging to research of weak or hybrid supervision learning in the past. To handle this problem, we propose a hybrid supervision learning framework for this kind of high resolution images with sufficient image-level coarse annotations and a few pixel-level fine labels. This framework, when applied in training patch model, can carefully make use of coarse image-level labels to refine generated pixel-level pseudo labels. Complete strategy is proposed to suppress pixel-level false positives and false negatives. A large hybrid annotated dataset is used to evaluate the effectiveness of hybrid supervision learning. By extracting pixel-level pseudo labels in initially image-level labeled samples, we achieve 5.2% higher specificity than purely training on existing labels while retaining 100% sensitivity, in the task of image-level classification to be positive or negative.

1.8CLMar 14, 2021
DeepStyle: User Style Embedding for Authorship Attribution of Short Texts

Zhiqiang Hu, Roy Ka-Wei Lee, Lei Wang et al.

Authorship attribution (AA), which is the task of finding the owner of a given text, is an important and widely studied research topic with many applications. Recent works have shown that deep learning methods could achieve significant accuracy improvement for the AA task. Nevertheless, most of these proposed methods represent user posts using a single type of feature (e.g., word bi-grams) and adopt a text classification approach to address the task. Furthermore, these methods offer very limited explainability of the AA results. In this paper, we address these limitations by proposing DeepStyle, a novel embedding-based framework that learns the representations of users' salient writing styles. We conduct extensive experiments on two real-world datasets from Twitter and Weibo. Our experiment results show that DeepStyle outperforms the state-of-the-art baselines on the AA task.

2.8CLOct 24, 2020Code
Text Style Transfer: A Review and Experimental Evaluation

Zhiqiang Hu, Roy Ka-Wei Lee, Charu C. Aggarwal et al.

The stylistic properties of text have intrigued computational linguistics researchers in recent years. Specifically, researchers have investigated the Text Style Transfer (TST) task, which aims to change the stylistic properties of the text while retaining its style independent content. Over the last few years, many novel TST algorithms have been developed, while the industry has leveraged these algorithms to enable exciting TST applications. The field of TST research has burgeoned because of this symbiosis. This article aims to provide a comprehensive review of recent research efforts on text style transfer. More concretely, we create a taxonomy to organize the TST models and provide a comprehensive summary of the state of the art. We review the existing evaluation methodologies for TST tasks and conduct a large-scale reproducibility study where we experimentally benchmark 19 state-of-the-art TST algorithms on two publicly available datasets. Finally, we expand on current trends and provide new perspectives on the new and exciting developments in the TST field.

13.6CVAug 17, 2020
Multi-organ Segmentation via Co-training Weight-averaged Models from Few-organ Datasets

Rui Huang, Yuanjie Zheng, Zhiqiang Hu et al.

Multi-organ segmentation has extensive applications in many clinical applications. To segment multiple organs of interest, it is generally quite difficult to collect full annotations of all the organs on the same images, as some medical centers might only annotate a portion of the organs due to their own clinical practice. In most scenarios, one might obtain annotations of a single or a few organs from one training set, and obtain annotations of the the other organs from another set of training images. Existing approaches mostly train and deploy a single model for each subset of organs, which are memory intensive and also time inefficient. In this paper, we propose to co-train weight-averaged models for learning a unified multi-organ segmentation network from few-organ datasets. We collaboratively train two networks and let the coupled networks teach each other on un-annotated organs. To alleviate the noisy teaching supervisions between the networks, the weighted-averaged models are adopted to produce more reliable soft labels. In addition, a novel region mask is utilized to selectively apply the consistent constraint on the un-annotated organ regions that require collaborative teaching, which further boosts the performance. Extensive experiments on three public available single-organ datasets LiTS, KiTS, Pancreas and manually-constructed single-organ datasets from MOBA show that our method can better utilize the few-organ datasets and achieves superior performance with less inference computational cost.

7.9CVApr 26, 2020
A Global Benchmark of Algorithms for Segmenting Late Gadolinium-Enhanced Cardiac Magnetic Resonance Imaging

Zhaohan Xiong, Qing Xia, Zhiqiang Hu et al.

Segmentation of cardiac images, particularly late gadolinium-enhanced magnetic resonance imaging (LGE-MRI) widely used for visualizing diseased cardiac structures, is a crucial first step for clinical diagnosis and treatment. However, direct segmentation of LGE-MRIs is challenging due to its attenuated contrast. Since most clinical studies have relied on manual and labor-intensive approaches, automatic methods are of high interest, particularly optimized machine learning approaches. To address this, we organized the "2018 Left Atrium Segmentation Challenge" using 154 3D LGE-MRIs, currently the world's largest cardiac LGE-MRI dataset, and associated labels of the left atrium segmented by three medical experts, ultimately attracting the participation of 27 international teams. In this paper, extensive analysis of the submitted algorithms using technical and biological metrics was performed by undergoing subgroup analysis and conducting hyper-parameter analysis, offering an overall picture of the major design choices of convolutional neural networks (CNNs) and practical considerations for achieving state-of-the-art left atrium segmentation. Results show the top method achieved a dice score of 93.2% and a mean surface to a surface distance of 0.7 mm, significantly outperforming prior state-of-the-art. Particularly, our analysis demonstrated that double, sequentially used CNNs, in which a first CNN is used for automatic region-of-interest localization and a subsequent CNN is used for refined regional segmentation, achieved far superior results than traditional methods and pipelines containing single CNNs. This large-scale benchmarking study makes a significant step towards much-improved segmentation methods for cardiac LGE-MRIs, and will serve as an important benchmark for evaluating and comparing the future works in the field.

18.9HCApr 3, 2020
SenseCare: A Research Platform for Medical Image Informatics and Interactive 3D Visualization

Qi Duan, Guotai Wang, Rui Wang et al.

Clinical research on smart health has an increasing demand for intelligent and clinic-oriented medical image computing algorithms and platforms that support various applications. To this end, we have developed SenseCare research platform, which is designed to facilitate translational research on intelligent diagnosis and treatment planning in various clinical scenarios. To enable clinical research with Artificial Intelligence (AI), SenseCare provides a range of AI toolkits for different tasks, including image segmentation, registration, lesion and landmark detection from various image modalities ranging from radiology to pathology. In addition, SenseCare is clinic-oriented and supports a wide range of clinical applications such as diagnosis and surgical planning for lung cancer, pelvic tumor, coronary artery disease, etc. SenseCare provides several appealing functions and features such as advanced 3D visualization, concurrent and efficient web-based access, fast data synchronization and high data security, multi-center deployment, support for collaborative research, etc. In this report, we present an overview of SenseCare as an efficient platform providing comprehensive toolkits and high extensibility for intelligent image analysis and clinical research in different application scenarios. We also summarize the research outcome through the collaboration with multiple hospitals.

8.5IVOct 9, 2019
Large-scale Gastric Cancer Screening and Localization Using Multi-task Deep Neural Network

Hong Yu, Xiaofan Zhang, Lingjun Song et al.

Gastric cancer is one of the most common cancers, which ranks third among the leading causes of cancer death. Biopsy of gastric mucosa is a standard procedure in gastric cancer screening test. However, manual pathological inspection is labor-intensive and time-consuming. Besides, it is challenging for an automated algorithm to locate the small lesion regions in the gigapixel whole-slide image and make the decision correctly.To tackle these issues, we collected large-scale whole-slide image dataset with detailed lesion region annotation and designed a whole-slide image analyzing framework consisting of 3 networks which could not only determine the screening result but also present the suspicious areas to the pathologist for reference. Experiments demonstrated that our proposed framework achieves sensitivity of 97.05% and specificity of 92.72% in screening task and Dice coefficient of 0.8331 in segmentation task. Furthermore, we tested our best model in real-world scenario on 10,315 whole-slide images collected from 4 medical centers.

18.3CVJul 9, 2019
Signet Ring Cell Detection With a Semi-supervised Learning Framework

Jiahui Li, Shuang Yang, Xiaodi Huang et al.

Signet ring cell carcinoma is a type of rare adenocarcinoma with poor prognosis. Early detection leads to huge improvement of patients' survival rate. However, pathologists can only visually detect signet ring cells under the microscope. This procedure is not only laborious but also prone to omission. An automatic and accurate signet ring cell detection solution is thus important but has not been investigated before. In this paper, we take the first step to present a semi-supervised learning framework for the signet ring cell detection problem. Self-training is proposed to deal with the challenge of incomplete annotations, and cooperative-training is adapted to explore the unlabeled regions. Combining the two techniques, our semi-supervised learning framework can make better use of both labeled and unlabeled data. Experiments on large real clinical data demonstrate the effectiveness of our design. Our framework achieves accurate signet ring cell detection and can be readily applied in the clinical trails. The dataset will be released soon to facilitate the development of the area.

4.7CVJul 9, 2019
Accurate Nuclear Segmentation with Center Vector Encoding

Jiahui Li, Zhiqiang Hu, Shuang Yang

Nuclear segmentation is important and frequently demanded for pathology image analysis, yet is also challenging due to nuclear crowdedness and possible occlusion. In this paper, we present a novel bottom-up method for nuclear segmentation. The concepts of Center Mask and Center Vector are introduced to better depict the relationship between pixels and nuclear instances. The instance differentiation process are thus largely simplified and easier to understand. Experiments demonstrate the effectiveness of Center Vector Encoding, where our method outperforms state-of-the-arts by a clear margin.

21.7LGOct 28, 2018Code
Towards Understanding Learning Representations: To What Extent Do Different Neural Networks Learn the Same Representation

Liwei Wang, Lunjia Hu, Jiayuan Gu et al.

It is widely believed that learning good representations is one of the main reasons for the success of deep neural networks. Although highly intuitive, there is a lack of theory and systematic approach quantitatively characterizing what representations do deep neural networks learn. In this work, we move a tiny step towards a theory and better understanding of the representations. Specifically, we study a simpler problem: How similar are the representations learned by two networks with identical architecture but trained from different initializations. We develop a rigorous theory based on the neuron activation subspace match model. The theory gives a complete characterization of the structure of neuron activation subspace matches, where the core concepts are maximum match and simple match which describe the overall and the finest similarity between sets of neurons in two networks respectively. We also propose efficient algorithms to find the maximum match and simple matches. Finally, we conduct extensive experiments using our algorithms. Experimental results suggest that, surprisingly, representations learned by the same convolutional layers of networks trained from different initializations are not as similar as prevalently expected, at least in terms of subspace match.

30.0CVSep 2, 2018Code
Learning to Navigate for Fine-grained Classification

Ze Yang, Tiange Luo, Dong Wang et al.

Fine-grained classification is challenging due to the difficulty of finding discriminative features. Finding those subtle traits that fully characterize the object is not straightforward. To handle this circumstance, we propose a novel self-supervision mechanism to effectively localize informative regions without the need of bounding-box/part annotations. Our model, termed NTS-Net for Navigator-Teacher-Scrutinizer Network, consists of a Navigator agent, a Teacher agent and a Scrutinizer agent. In consideration of intrinsic consistency between informativeness of the regions and their probability being ground-truth class, we design a novel training paradigm, which enables Navigator to detect most informative regions under the guidance from Teacher. After that, the Scrutinizer scrutinizes the proposed regions from Navigator and makes predictions. Our model can be viewed as a multi-agent cooperation, wherein agents benefit from each other, and make progress together. NTS-Net can be trained end-to-end, while provides accurate fine-grained classification predictions as well as highly informative regions during inference. We achieve state-of-the-art performance in extensive benchmark datasets.