Ying Long

Qiuhong Wei, Ying Cui, Mengwei Ding et al.

Large language models (LLMs) have demonstrated potential applications in medicine, yet data privacy and computational burden limit their deployment in healthcare institutions. Open-source and lightweight versions of LLMs emerge as potential solutions, but their performance, particularly in pediatric settings remains underexplored. In this cross-sectional study, 250 patient consultation questions were randomly selected from a public online medical forum, with 10 questions from each of 25 pediatric departments, spanning from December 1, 2022, to October 30, 2023. Two lightweight open-source LLMs, ChatGLM3-6B and Vicuna-7B, along with a larger-scale model, Vicuna-13B, and the widely-used proprietary ChatGPT-3.5, independently answered these questions in Chinese between November 1, 2023, and November 7, 2023. To assess reproducibility, each inquiry was replicated once. We found that ChatGLM3-6B demonstrated higher accuracy and completeness than Vicuna-13B and Vicuna-7B (P < .001), but all were outperformed by ChatGPT-3.5. ChatGPT-3.5 received the highest ratings in accuracy (65.2%) compared to ChatGLM3-6B (41.2%), Vicuna-13B (11.2%), and Vicuna-7B (4.4%). Similarly, in completeness, ChatGPT-3.5 led (78.4%), followed by ChatGLM3-6B (76.0%), Vicuna-13B (34.8%), and Vicuna-7B (22.0%) in highest ratings. ChatGLM3-6B matched ChatGPT-3.5 in readability, both outperforming Vicuna models (P < .001). In terms of empathy, ChatGPT-3.5 outperformed the lightweight LLMs (P < .001). In safety, all models performed comparably well (P > .05), with over 98.4% of responses being rated as safe. Repetition of inquiries confirmed these findings. In conclusion, Lightweight LLMs demonstrate promising application in pediatric healthcare. However, the observed gap between lightweight and large-scale proprietary LLMs underscores the need for continued development efforts.

Hanyue Zhang, Zhiliu Yang, Xinhe Zuo et al.

This paper proposes a novel framework for large-scale scene reconstruction based on 3D Gaussian splatting (3DGS) and aims to address the scalability and accuracy challenges faced by existing methods. For tackling the scalability issue, we split the large scene into multiple cells, and the candidate point-cloud and camera views of each cell are correlated through a visibility-based camera selection and a progressive point-cloud extension. To reinforce the rendering quality, three highlighted improvements are made in comparison with vanilla 3DGS, which are a strategy of the ray-Gaussian intersection and the novel Gaussians density control for learning efficiency, an appearance decoupling module based on ConvKAN network to solve uneven lighting conditions in large-scale scenes, and a refined final loss with the color loss, the depth distortion loss, and the normal consistency loss. Finally, the seamless stitching procedure is executed to merge the individual Gaussian radiance field for novel view synthesis across different cells. Evaluation of Mill19, Urban3D, and MatrixCity datasets shows that our method consistently generates more high-fidelity rendering results than state-of-the-art methods of large-scale scene reconstruction. We further validate the generalizability of the proposed approach by rendering on self-collected video clips recorded by a commercial drone.

Yecheng Zhang, Huimin Zhao, Ying Long

Rapidly acquiring three-dimensional (3D) building data, including geometric attributes like rooftop, height and orientations, as well as indicative attributes like function, quality, and age, is essential for accurate urban analysis, simulations, and policy updates. Current building datasets suffer from incomplete coverage of building multi-attributes. This paper introduces a geospatial artificial intelligence (GeoAI) framework for large-scale building modeling, presenting the first national-scale Multi-Attribute Building dataset (CMAB), covering 3,667 spatial cities, 29 million buildings, and 21.3 billion square meters of rooftops with an F1-Score of 89.93% in OCRNet-based extraction, totaling 337.7 billion cubic meters of building stock. We trained bootstrap aggregated XGBoost models with city administrative classifications, incorporating features such as morphology, location, and function. Using multi-source data, including billions of high-resolution Google Earth images and 60 million street view images (SVIs), we generated rooftop, height, function, age, and quality attributes for each building. Accuracy was validated through model benchmarks, existing similar products, and manual SVI validation, mostly above 80%. Our dataset and results are crucial for global SDGs and urban planning.

Dou Liu, Ying Long, Sophia Zuoqiu et al.

Effective physician-patient communications in pre-diagnostic environments, and most specifically in complex and sensitive medical areas such as infertility, are critical but consume a lot of time and, therefore, cause clinic workflows to become inefficient. Recent advancements in Large Language Models (LLMs) offer a potential solution for automating conversational medical history-taking and improving diagnostic accuracy. This study evaluates the feasibility and performance of LLMs in those tasks for infertility cases. An AI-driven conversational system was developed to simulate physician-patient interactions with ChatGPT-4o and ChatGPT-4o-mini. A total of 70 real-world infertility cases were processed, generating 420 diagnostic histories. Model performance was assessed using F1 score, Differential Diagnosis (DDs) Accuracy, and Accuracy of Infertility Type Judgment (ITJ). ChatGPT-4o-mini outperformed ChatGPT-4o in information extraction accuracy (F1 score: 0.9258 vs. 0.9029, p = 0.045, d = 0.244) and demonstrated higher completeness in medical history-taking (97.58% vs. 77.11%), suggesting that ChatGPT-4o-mini is more effective in extracting detailed patient information, which is critical for improving diagnostic accuracy. In contrast, ChatGPT-4o performed slightly better in differential diagnosis accuracy (2.0524 vs. 2.0048, p > 0.05). ITJ accuracy was higher in ChatGPT-4o-mini (0.6476 vs. 0.5905) but with lower consistency (Cronbach's $α$ = 0.562), suggesting variability in classification reliability. Both models demonstrated strong feasibility in automating infertility history-taking, with ChatGPT-4o-mini excelling in completeness and extraction accuracy. In future studies, expert validation for accuracy and dependability in a clinical setting, AI model fine-tuning, and larger datasets with a mix of cases of infertility have to be prioritized.

Dou Liu, Ying Long, Sophia Zuoqiu et al.

Large language models (LLMs) are increasingly adopted in clinical decision support, yet aligning them with the multifaceted reasoning pathways of real-world medicine remains a major challenge. Using more than 8,000 infertility treatment records, we systematically evaluate four alignment strategies: Supervised Fine-Tuning (SFT), Direct Preference Optimization (DPO), Group Relative Policy Optimization (GRPO), and In-Context Learning (ICL) through a dual-layer framework combining automatic benchmarks with blinded doctor-in-the-loop assessments. GRPO achieves the highest algorithmic accuracy across multiple decision layers, confirming the value of reinforcement-based optimization for structured prediction tasks. However, clinicians consistently prefer the SFT model, citing clearer reasoning processes (p = 0.035) and higher therapeutic feasibility (p = 0.019). In blinded pairwise comparisons, SFT attains the highest winning rate (51.2%), outperforming both GRPO (26.2%) and even physicians' original decisions (22.7%). These results reveal an alignment paradox: algorithmic improvements do not necessarily translate into higher clinical trust, and may diverge from human-centered preferences. Our findings highlight the need for alignment strategies that prioritize clinically interpretable and practically feasible reasoning, rather than solely optimizing decision-level accuracy.

Dou Liu, Ying Long, Sophia Zuoqiu et al.

Creating high-quality clinical Chains-of-Thought (CoTs) is crucial for explainable medical Artificial Intelligence (AI) while constrained by data scarcity. Although Large Language Models (LLMs) can synthesize medical data, their clinical reliability remains unverified. This study evaluates the reliability of LLM-generated CoTs and investigates prompting strategies to enhance their quality. In a blinded comparative study, senior clinicians in Assisted Reproductive Technology (ART) evaluated CoTs generated via three distinct strategies: Zero-shot, Random Few-shot (using shallow examples), and Selective Few-shot (using diverse, high-quality examples). These expert ratings were compared against evaluations from a state-of-the-art AI model (GPT-4o). The Selective Few-shot strategy significantly outperformed other strategies across all human evaluation metrics (p < .001). Critically, the Random Few-shot strategy offered no significant improvement over the Zero-shot baseline, demonstrating that low-quality examples are as ineffective as no examples. The success of the Selective strategy is attributed to two principles: "Gold-Standard Depth" (reasoning quality) and "Representative Diversity" (generalization). Notably, the AI evaluator failed to discern these critical performance differences. The clinical reliability of synthetic CoTs is dictated by strategic prompt curation, not the mere presence of examples. We propose a "Dual Principles" framework as a foundational methodology to generate trustworthy data at scale. This work offers a validated solution to the data bottleneck and confirms the indispensable role of human expertise in evaluating high-stakes clinical AI.

Qiyuan Hong, Huimin Zhao, Ying Long

This study leverages GPT-4o to assess neighbourhood housing quality using multi-source textural user-generated content (UGC) from Dianping, Weibo, and the Government Message Board. The analysis involves filtering relevant texts, extracting structured evaluation units, and conducting sentiment scoring. A refined housing quality assessment system with 46 indicators across 11 categories was developed, highlighting an objective-subjective method gap and platform-specific differences in focus. GPT-4o outperformed rule-based and BERT models, achieving 92.5% accuracy in fine-tuned settings. The findings underscore the value of integrating UGC and GPT-driven analysis for scalable, resident-centric urban assessments, offering practical insights for policymakers and urban planners.