Yuchen Yuan

Xikai Yang, Juzheng Miao, Yuchen Yuan et al.

Medical large vision-language models (LVLMs) have demonstrated promising performance across various single-image question answering (QA) benchmarks, yet their capability in processing multi-image clinical scenarios remains underexplored. Unlike single image based tasks, medical tasks involving multiple images often demand sophisticated visual understanding capabilities, such as temporal reasoning and cross-modal analysis, which are poorly supported by current medical LVLMs. To bridge this critical gap, we present the Med-MIM instruction dataset, comprising 83.2K medical multi-image QA pairs that span four types of multi-image visual abilities (temporal understanding, reasoning, comparison, co-reference). Using this dataset, we fine-tune Mantis and LLaVA-Med, resulting in two specialized medical VLMs: MIM-LLaVA-Med and Med-Mantis, both optimized for multi-image analysis. Additionally, we develop the Med-MIM benchmark to comprehensively evaluate the medical multi-image understanding capabilities of LVLMs. We assess eight popular LVLMs, including our two models, on the Med-MIM benchmark. Experimental results show that both Med-Mantis and MIM-LLaVA-Med achieve superior performance on the held-in and held-out subsets of the Med-MIM benchmark, demonstrating that the Med-MIM instruction dataset effectively enhances LVLMs' multi-image understanding capabilities in the medical domain.

Xikai Yang, Jian Wu, Xi Wang et al.

Glaucoma is one of the major eye diseases that leads to progressive optic nerve fiber damage and irreversible blindness, afflicting millions of individuals. Glaucoma forecast is a good solution to early screening and intervention of potential patients, which is helpful to prevent further deterioration of the disease. It leverages a series of historical fundus images of an eye and forecasts the likelihood of glaucoma occurrence in the future. However, the irregular sampling nature and the imbalanced class distribution are two challenges in the development of disease forecasting approaches. To this end, we introduce the Multi-scale Spatio-temporal Transformer Network (MST-former) based on the transformer architecture tailored for sequential image inputs, which can effectively learn representative semantic information from sequential images on both temporal and spatial dimensions. Specifically, we employ a multi-scale structure to extract features at various resolutions, which can largely exploit rich spatial information encoded in each image. Besides, we design a time distance matrix to scale time attention in a non-linear manner, which could effectively deal with the irregularly sampled data. Furthermore, we introduce a temperature-controlled Balanced Softmax Cross-entropy loss to address the class imbalance issue. Extensive experiments on the Sequential fundus Images for Glaucoma Forecast (SIGF) dataset demonstrate the superiority of the proposed MST-former method, achieving an AUC of 98.6% for glaucoma forecasting. Besides, our method shows excellent generalization capability on the Alzheimer's Disease Neuroimaging Initiative (ADNI) MRI dataset, with an accuracy of 90.3% for mild cognitive impairment and Alzheimer's disease prediction, outperforming the compared method by a large margin.

Yiyi Zhang, Yuchen Yuan, Ying Zheng et al.

Surgical triplet recognition, which involves identifying instrument, verb, target, and their combinations, is a complex surgical scene understanding challenge plagued by long-tailed data distribution. The mainstream multi-task learning paradigm benefiting from cross-task collaborative promotion has shown promising performance in identifying triples, but two key challenges remain: 1) inter-task optimization conflicts caused by entangling task-generic and task-specific representations; 2) intra-task optimization conflicts due to class-imbalanced training data. To overcome these difficulties, we propose the MLLM-Engaged Joint Optimization (MEJO) framework that empowers both inter- and intra-task optimization for surgical triplet recognition. For inter-task optimization, we introduce the Shared-Specific-Disentangled (S$^2$D) learning scheme that decomposes representations into task-shared and task-specific components. To enhance task-shared representations, we construct a Multimodal Large Language Model (MLLM) powered probabilistic prompt pool to dynamically augment visual features with expert-level semantic cues. Additionally, comprehensive task-specific cues are modeled via distinct task prompts covering the temporal-spatial dimensions, effectively mitigating inter-task ambiguities. To tackle intra-task optimization conflicts, we develop a Coordinated Gradient Learning (CGL) strategy, which dissects and rebalances the positive-negative gradients originating from head and tail classes for more coordinated learning behaviors. Extensive experiments on the CholecT45 and CholecT50 datasets demonstrate the superiority of our proposed framework, validating its effectiveness in handling optimization conflicts.