Rui Xu

Peixiang Huang, Songtao Zhang, Yulu Gan et al. · pku

Deep learning in digital pathology brings intelligence and automation as substantial enhancements to pathological analysis, the gold standard of clinical diagnosis. However, multiple steps from tissue preparation to slide imaging introduce various image corruptions, making it difficult for deep neural network (DNN) models to achieve stable diagnostic results for clinical use. In order to assess and further enhance the robustness of the models, we analyze the physical causes of the full-stack corruptions throughout the pathological life-cycle and propose an Omni-Corruption Emulation (OmniCE) method to reproduce 21 types of corruptions quantified with 5-level severity. We then construct three OmniCE-corrupted benchmark datasets at both patch level and slide level and assess the robustness of popular DNNs in classification and segmentation tasks. Further, we explore to use the OmniCE-corrupted datasets as augmentation data for training and experiments to verify that the generalization ability of the models has been significantly enhanced.

Rui Xu, Wenkang Qin, Peixiang Huang et al.

Deep Neural Networks (DNNs) are expected to provide explanation for users to understand their black-box predictions. Saliency map is a common form of explanation illustrating the heatmap of feature attributions, but it suffers from noise in distinguishing important features. In this paper, we propose a model-agnostic learning method called Saliency Constrained Adaptive Adversarial Training (SCAAT) to improve the quality of such DNN interpretability. By constructing adversarial samples under the guidance of saliency map, SCAAT effectively eliminates most noise and makes saliency maps sparser and more faithful without any modification to the model architecture. We apply SCAAT to multiple DNNs and evaluate the quality of the generated saliency maps on various natural and pathological image datasets. Evaluations on different domains and metrics show that SCAAT significantly improves the interpretability of DNNs by providing more faithful saliency maps without sacrificing their predictive power.

Qiujie Dong, Huibiao Wen, Rui Xu et al.

Quadrilateral mesh generation plays a crucial role in numerical simulations within Computer-Aided Design and Engineering (CAD/E). Producing high-quality quadrangulation typically requires satisfying four key criteria. First, the quadrilateral mesh should closely align with principal curvature directions. Second, singular points should be strategically placed and effectively minimized. Third, the mesh should accurately conform to sharp feature edges. Lastly, quadrangulation results should exhibit robustness against noise and minor geometric variations. Existing methods generally involve first computing a regular cross field to represent quad element orientations across the surface, followed by extracting a quadrilateral mesh aligned closely with this cross field. A primary challenge with this approach is balancing the smoothness of the cross field with its alignment to pre-computed principal curvature directions, which are sensitive to small surface perturbations and often ill-defined in spherical or planar regions. To tackle this challenge, we propose NeurCross, a novel framework that simultaneously optimizes a cross field and a neural signed distance function (SDF), whose zero-level set serves as a proxy of the input shape. Our joint optimization is guided by three factors: faithful approximation of the optimized SDF surface to the input surface, alignment between the cross field and the principal curvature field derived from the SDF surface, and smoothness of the cross field. Acting as an intermediary, the neural SDF contributes in two essential ways. First, it provides an alternative, optimizable base surface exhibiting more regular principal curvature directions for guiding the cross field. Second, we leverage the Hessian matrix of the neural SDF to implicitly enforce cross field alignment with principal curvature directions...