Shen Wang

Khayrul Islam, Ratul Paul, Shen Wang et al.

Label-free cell classification is advantageous for supplying pristine cells for further use or examination, yet existing techniques frequently fall short in terms of specificity and speed. In this study, we address these limitations through the development of a novel machine learning framework, Multiplex Image Machine Learning (MIML). This architecture uniquely combines label-free cell images with biomechanical property data, harnessing the vast, often underutilized morphological information intrinsic to each cell. By integrating both types of data, our model offers a more holistic understanding of the cellular properties, utilizing morphological information typically discarded in traditional machine learning models. This approach has led to a remarkable 98.3\% accuracy in cell classification, a substantial improvement over models that only consider a single data type. MIML has been proven effective in classifying white blood cells and tumor cells, with potential for broader application due to its inherent flexibility and transfer learning capability. It's particularly effective for cells with similar morphology but distinct biomechanical properties. This innovative approach has significant implications across various fields, from advancing disease diagnostics to understanding cellular behavior.

Shen Wang, Mehdi Nikfar, Joshua C. Agar et al.

Computational fluid dynamics (CFD) simulations are broadly applied in engineering and physics. A standard description of fluid dynamics requires solving the Navier-Stokes (N-S) equations in different flow regimes. However, applications of CFD simulations are computationally-limited by the availability, speed, and parallelism of high-performance computing. To improve computational efficiency, machine learning techniques have been used to create accelerated data-driven approximations for CFD. A majority of such approaches rely on large labeled CFD datasets that are expensive to obtain at the scale necessary to build robust data-driven models. We develop a weakly-supervised approach to solve the steady-state N-S equations under various boundary conditions, using a multi-channel input with boundary and geometric conditions. We achieve state-of-the-art results without any labeled simulation data, but using a custom data-driven and physics-informed loss function by using and small-scale solutions to prime the model to solve the N-S equations. To improve the resolution and predictability, we train stacked models of increasing complexity generating the numerical solutions for N-S equations. Without expensive computations, our model achieves high predictability with a variety of obstacles and boundary conditions. Given its high flexibility, the model can generate a solution on a 64 x 64 domain within 5 ms on a regular desktop computer which is 1000 times faster than a regular CFD solver. Translation of interactive CFD simulation on local consumer computing hardware enables new applications in real-time predictions on the internet of things devices where data transfer is prohibitive and can increase the scale, speed, and computational cost of boundary-value fluid problems.

Shen Wang, Kongming Liang, Chengwei Pan et al.

The midline related pathological image features are crucial for evaluating the severity of brain compression caused by stroke or traumatic brain injury (TBI). The automated midline delineation not only improves the assessment and clinical decision making for patients with stroke symptoms or head trauma but also reduces the time of diagnosis. Nevertheless, most of the previous methods model the midline by localizing the anatomical points, which are hard to detect or even missing in severe cases. In this paper, we formulate the brain midline delineation as a segmentation task and propose a three-stage framework. The proposed framework firstly aligns an input CT image into the standard space. Then, the aligned image is processed by a midline detection network (MD-Net) integrated with the CoordConv Layer and Cascade AtrousCconv Module to obtain the probability map. Finally, we formulate the optimal midline selection as a pathfinding problem to solve the problem of the discontinuity of midline delineation. Experimental results show that our proposed framework can achieve superior performance on one in-house dataset and one public dataset.

Yue Wang, Chenwei Zhang, Shen Wang et al.

We formalize networks with evolving structures as temporal networks and propose a generative link prediction model, Generative Link Sequence Modeling (GLSM), to predict future links for temporal networks. GLSM captures the temporal link formation patterns from the observed links with a sequence modeling framework and has the ability to generate the emerging links by inferring from the probability distribution on the potential future links. To avoid overfitting caused by treating each link as a unique token, we propose a self-tokenization mechanism to transform each raw link in the network to an abstract aggregation token automatically. The self-tokenization is seamlessly integrated into the sequence modeling framework, which allows the proposed GLSM model to have the generalization capability to discover link formation patterns beyond raw link sequences. We compare GLSM with the existing state-of-art methods on five real-world datasets. The experimental results demonstrate that GLSM obtains future positive links effectively in a generative fashion while achieving the best performance (2-10\% improvements on AUC) among other alternatives.