Xinrui Chen

Yongxian Wei, Yilin Zhao, Li Shen et al.

Data synthesis for training large reasoning models offers a scalable alternative to limited, human-curated datasets, enabling the creation of high-quality data. However, existing approaches face several challenges: (i) indiscriminate generation that ignores the solver's ability and yields low-value problems, or reliance on complex data pipelines to balance problem difficulty; and (ii) a lack of reasoning in problem generation, leading to shallow problem variants. In this paper, we develop a problem generator that reasons explicitly to plan problem directions before synthesis and adapts difficulty to the solver's ability. Specifically, we construct related problem pairs and augment them with intermediate problem-design CoT produced by a reasoning model. These data bootstrap problem-design strategies from the generator. Then, we treat the solver's feedback on synthetic problems as a reward signal, enabling the generator to calibrate difficulty and produce complementary problems near the edge of the solver's competence. Extensive experiments on 10 mathematical and general reasoning benchmarks show that our method achieves an average improvement of 2.5% and generalizes to both language and vision-language models. Moreover, a solver trained on the synthesized data provides improved rewards for continued generator training, enabling co-evolution and yielding a further 0.7% performance gain. Our code will be made publicly available here.

Xinrui Chen, Yizhen Luo, Siqi Fan et al.

De novo functional protein design aims to generate protein sequences that realize specified biochemical functions without relying on evolutionary templates, enabling broad applications in biotechnology and medicine. Existing approaches adopt either direct function-to-sequence mapping or decoupled structure-sequence generation strategies but often fail to achieve functionality and foldability simultaneously. To address this, we propose CodeFP, a Co-generative protein language model for de novo Functional Protein design that simultaneously decodes sequence and structure tokens, thereby enabling superior simultaneous realization of functionality and foldability. CodeFP utilizes functional local structures to enrich functional semantic encodings, overcoming the suboptimal translation of flat encodings into structure tokens, while introducing auxiliary functional supervision to alleviate training ambiguity stemming from the one-to-many structure-to-token mapping. Extensive experiments show that CodeFP consistently achieves average improvements of 6.1% in functional consistency and 3.2% in foldability over the strongest baseline.