Logan Grosenick

Amanda M. Buch, Conor Liston, Logan Grosenick

AI-enabled precision medicine promises a transformational improvement in healthcare outcomes by enabling data-driven personalized diagnosis, prognosis, and treatment. However, the well-known "curse of dimensionality" and the clustered structure of biomedical data together interact to present a joint challenge in the high dimensional, limited observation precision medicine regime. To overcome both issues simultaneously we propose a simple and scalable approach to joint clustering and embedding that combines standard embedding methods with a convex clustering penalty in a modular way. This novel, cluster-aware embedding approach overcomes the complexity and limitations of current joint embedding and clustering methods, which we show with straightforward implementations of hierarchically clustered principal component analysis (PCA), locally linear embedding (LLE), and canonical correlation analysis (CCA). Through both numerical experiments and real-world examples, we demonstrate that our approach outperforms traditional and contemporary clustering methods on highly underdetermined problems (e.g., with just tens of observations) as well as on large sample datasets. Importantly, our approach does not require the user to choose the desired number of clusters, but instead yields interpretable dendrograms of hierarchically clustered embeddings. Thus our approach improves significantly on existing methods for identifying patient subgroups in multiomics and neuroimaging data, enabling scalable and interpretable biomarkers for precision medicine.

Ruchi Sandilya, Sumaira Perez, Charles Lynch et al.

Diffusion models excel at generation, but their latent spaces are not explicitly organized for interpretable control. We introduce ConDA (Contrastive Diffusion Alignment), a framework that applies contrastive learning within diffusion embeddings to align latent geometry with system dynamics. Motivated by recent advances showing that contrastive objectives can recover more disentangled and structured representations, ConDA organizes diffusion latents such that traversal directions reflect underlying dynamical factors. Within this contrastively structured space, ConDA enables nonlinear trajectory traversal that supports faithful interpolation, extrapolation, and controllable generation. Across benchmarks in fluid dynamics, neural calcium imaging, therapeutic neurostimulation, and facial expression, ConDA produces interpretable latent representations with improved controllability compared to linear traversals and conditioning-based baselines. These results suggest that diffusion latents encode dynamics-relevant structure, but exploiting this structure requires latent organization and traversal along the latent manifold.

Marzieh Ajirak, Oded Bein, Ellen Rose Bowen et al.

We propose a unified framework for adaptive routing in multitask, multimodal prediction settings where data heterogeneity and task interactions vary across samples. Motivated by applications in psychotherapy where structured assessments and unstructured clinician notes coexist with partially missing data and correlated outcomes, we introduce a routing-based architecture that dynamically selects modality processing pathways and task-sharing strategies on a per-sample basis. Our model defines multiple modality paths, including raw and fused representations of text and numeric features and learns to route each input through the most informative expert combination. Task-specific predictions are produced by shared or independent heads depending on the routing decision, and the entire system is trained end-to-end. We evaluate the model on both synthetic data and real-world psychotherapy notes predicting depression and anxiety outcomes. Our experiments show that our method consistently outperforms fixed multitask or single-task baselines, and that the learned routing policy provides interpretable insights into modality relevance and task structure. This addresses critical challenges in personalized healthcare by enabling per-subject adaptive information processing that accounts for data heterogeneity and task correlations. Applied to psychotherapy, this framework could improve mental health outcomes, enhance treatment assignment precision, and increase clinical cost-effectiveness through personalized intervention strategies.