Alireza Sadeghi

Alireza Sadeghi, Alireza Rezaee, Farshid Hajati

Cardiac resynchronization therapy (CRT) is a treatment that is used to compensate for irregularities in the heartbeat. Studies have shown that this treatment is more effective in heart patients with left bundle branch block (LBBB) arrhythmia. Therefore, identifying this arrhythmia is an important initial step in determining whether or not to use CRT. On the other hand, traditional methods for detecting LBBB on electrocardiograms (ECG) are often associated with errors. Thus, there is a need for an accurate method to diagnose this arrhythmia from ECG data. Machine learning, as a new field of study, has helped to increase human systems' performance. Deep learning, as a newer subfield of machine learning, has more power to analyze data and increase systems accuracy. This study presents a deep learning model for the detection of LBBB arrhythmia from 12-lead ECG data. This model consists of 1D dilated convolutional layers. Attention mechanism has also been used to identify important input data features and classify inputs more accurately. The proposed model is trained and validated on a database containing 10344 12-lead ECG samples using the 10-fold cross-validation method. The final results obtained by the model on the 12-lead ECG data are as follows. Accuracy: 98.80+-0.08%, specificity: 99.33+-0.11 %, F1 score: 73.97+-1.8%, and area under the receiver operating characteristics curve (AUC): 0.875+-0.0192. These results indicate that the proposed model in this study can effectively diagnose LBBB with good efficiency and, if used in medical centers, will greatly help diagnose this arrhythmia and early treatment.

Alireza Sadeghi, Farshid Hajati, Ahmadreza Argha et al.

Integrating heterogeneous biomedical data including imaging, omics, and clinical records supports accurate diagnosis and personalised care. Graph-based models fuse such non-Euclidean data by capturing spatial and relational structure, yet clinical uptake requires regulator-ready interpretability. We present the first technical survey of interpretable graph based models for multimodal biomedical data, covering 26 studies published between Jan 2019 and Sep 2024. Most target disease classification, notably cancer and rely on static graphs from simple similarity measures, while graph-native explainers are rare; post-hoc methods adapted from non-graph domains such as gradient saliency, and SHAP predominate. We group existing approaches into four interpretability families, outline trends such as graph-in-graph hierarchies, knowledge-graph edges, and dynamic topology learning, and perform a practical benchmark. Using an Alzheimer disease cohort, we compare Sensitivity Analysis, Gradient Saliency, SHAP and Graph Masking. SHAP and Sensitivity Analysis recover the broadest set of known AD pathways and Gene-Ontology terms, whereas Gradient Saliency and Graph Masking surface complementary metabolic and transport signatures. Permutation tests show all four beat random gene sets, but with distinct trade-offs: SHAP and Graph Masking offer deeper biology at higher compute cost, while Gradient Saliency and Sensitivity Analysis are quicker though coarser. We also provide a step-by-step flowchart covering graph construction, explainer choice and resource budgeting to help researchers balance transparency and performance. This review synthesises the state of interpretable graph learning for multimodal medicine, benchmarks leading techniques, and charts future directions, from advanced XAI tools to under-studied diseases, serving as a concise reference for method developers and translational scientists.