Development of Skip Connection in Deep Neural Networks for Computer Vision and Medical Image Analysis: A SurveyGuoping Xu, Xiaxia Wang, Xinglong Wu et al.
Deep learning has made significant progress in computer vision, specifically in image classification, object detection, and semantic segmentation. The skip connection has played an essential role in the architecture of deep neural networks,enabling easier optimization through residual learning during the training stage and improving accuracy during testing. Many neural networks have inherited the idea of residual learning with skip connections for various tasks, and it has been the standard choice for designing neural networks. This survey provides a comprehensive summary and outlook on the development of skip connections in deep neural networks. The short history of skip connections is outlined, and the development of residual learning in deep neural networks is surveyed. The effectiveness of skip connections in the training and testing stages is summarized, and future directions for using skip connections in residual learning are discussed. Finally, we summarize seminal papers, source code, models, and datasets that utilize skip connections in computer vision, including image classification, object detection, semantic segmentation, and image reconstruction. We hope this survey could inspire peer researchers in the community to develop further skip connections in various forms and tasks and the theory of residual learning in deep neural networks. The project page can be found at https://github.com/apple1986/Residual_Learning_For_Images
A SAM-guided and Match-based Semi-Supervised Segmentation Framework for Medical ImagingGuoping Xu, Xiaoxue Qian, Hua Chieh Shao et al.
This study introduces SAMatch, a SAM-guided Match-based framework for semi-supervised medical image segmentation, aimed at improving pseudo label quality in data-scarce scenarios. While Match-based frameworks are effective, they struggle with low-quality pseudo labels due to the absence of ground truth. SAM, pre-trained on a large dataset, generalizes well across diverse tasks and assists in generating high-confidence prompts, which are then used to refine pseudo labels via fine-tuned SAM. SAMatch is trained end-to-end, allowing for dynamic interaction between the models. Experiments on the ACDC cardiac MRI, BUSI breast ultrasound, and MRLiver datasets show SAMatch achieving state-of-the-art results, with Dice scores of 89.36%, 77.76%, and 80.04%, respectively, using minimal labeled data. SAMatch effectively addresses challenges in semi-supervised segmentation, offering a powerful tool for segmentation in data-limited environments. Code and data are available at https://github.com/apple1986/SAMatch.
Noise Adaption Network for Morse Code Image ClassificationXiaxia Wang, XueSong Leng, Guoping Xu
The escalating significance of information security has underscored the per-vasive role of encryption technology in safeguarding communication con-tent. Morse code, a well-established and effective encryption method, has found widespread application in telegraph communication and various do-mains. However, the transmission of Morse code images faces challenges due to diverse noises and distortions, thereby hindering comprehensive clas-sification outcomes. Existing methodologies predominantly concentrate on categorizing Morse code images affected by a single type of noise, neglecting the multitude of scenarios that noise pollution can generate. To overcome this limitation, we propose a novel two-stage approach, termed the Noise Adaptation Network (NANet), for Morse code image classification. Our method involves exclusive training on pristine images while adapting to noisy ones through the extraction of critical information unaffected by noise. In the initial stage, we introduce a U-shaped network structure designed to learn representative features and denoise images. Subsequently, the second stage employs a deep convolutional neural network for classification. By leveraging the denoising module from the first stage, our approach achieves enhanced accuracy and robustness in the subsequent classification phase. We conducted an evaluation of our approach on a diverse dataset, encom-passing Gaussian, salt-and-pepper, and uniform noise variations. The results convincingly demonstrate the superiority of our methodology over existing approaches. The datasets are available on https://github.com/apple1986/MorseCodeImageClassify
Depthwise-Dilated Convolutional Adapters for Medical Object Tracking and Segmentation Using the Segment Anything Model 2Guoping Xu, Christopher Kabat, You Zhang
Recent advances in medical image segmentation have been driven by deep learning; however, most existing methods remain limited by modality-specific designs and exhibit poor adaptability to dynamic medical imaging scenarios. The Segment Anything Model 2 (SAM2) and its related variants, which introduce a streaming memory mechanism for real-time video segmentation, present new opportunities for prompt-based, generalizable solutions. Nevertheless, adapting these models to medical video scenarios typically requires large-scale datasets for retraining or transfer learning, leading to high computational costs and the risk of catastrophic forgetting. To address these challenges, we propose DD-SAM2, an efficient adaptation framework for SAM2 that incorporates a Depthwise-Dilated Adapter (DD-Adapter) to enhance multi-scale feature extraction with minimal parameter overhead. This design enables effective fine-tuning of SAM2 on medical videos with limited training data. Unlike existing adapter-based methods focused solely on static images, DD-SAM2 fully exploits SAM2's streaming memory for medical video object tracking and segmentation. Comprehensive evaluations on TrackRad2025 (tumor segmentation) and EchoNet-Dynamic (left ventricle tracking) datasets demonstrate superior performance, achieving Dice scores of 0.93 and 0.97, respectively. To the best of our knowledge, this work provides an initial attempt at systematically exploring adapter-based SAM2 fine-tuning for medical video segmentation and tracking. Code, datasets, and models will be publicly available at https://github.com/apple1986/DD-SAM2.
Is the medical image segmentation problem solved? A survey of current developments and future directionsGuoping Xu, Jayaram K. Udupa, Jax Luo et al.
Medical image segmentation has advanced rapidly over the past two decades, largely driven by deep learning, which has enabled accurate and efficient delineation of cells, tissues, organs, and pathologies across diverse imaging modalities. This progress raises a fundamental question: to what extent have current models overcome persistent challenges, and what gaps remain? In this work, we provide an in-depth review of medical image segmentation, tracing its progress and key developments over the past decade. We examine core principles, including multiscale analysis, attention mechanisms, and the integration of prior knowledge, across the encoder, bottleneck, skip connections, and decoder components of segmentation networks. Our discussion is organized around seven key dimensions: (1) the shift from supervised to semi-/unsupervised learning, (2) the transition from organ segmentation to lesion-focused tasks, (3) advances in multi-modality integration and domain adaptation, (4) the role of foundation models and transfer learning, (5) the move from deterministic to probabilistic segmentation, (6) the progression from 2D to 3D and 4D segmentation, and (7) the trend from model invocation to segmentation agents. Together, these perspectives provide a holistic overview of the trajectory of deep learning-based medical image segmentation and aim to inspire future innovation. To support ongoing research, we maintain a continually updated repository of relevant literature and open-source resources at https://github.com/apple1986/medicalSegReview
TSMS-SAM2: Multi-scale Temporal Sampling Augmentation and Memory-Splitting Pruning for Promptable Video Object Segmentation and Tracking in Surgical ScenariosGuoping Xu, Hua-Chieh Shao, You Zhang
Promptable video object segmentation and tracking (VOST) has seen significant advances with the emergence of foundation models like Segment Anything Model 2 (SAM2); however, their application in surgical video analysis remains challenging due to complex motion dynamics and the redundancy of memory that impedes effective learning. In this work, we propose TSMS-SAM2, a novel framework that enhances promptable VOST in surgical videos by addressing challenges of rapid object motion and memory redundancy in SAM2. TSMS-SAM2 introduces two key strategies: multi-temporal-scale video sampling augmentation to improve robustness against motion variability, and a memory splitting and pruning mechanism that organizes and filters past frame features for more efficient and accurate segmentation. Evaluated on EndoVis2017 and EndoVis2018 datasets, TSMS-SAM2 achieved the highest mean Dice scores of 95.24 and 86.73, respectively, outperforming prior SAM-based and task-specific methods. Extensive ablation studies confirm the effectiveness of multiscale temporal augmentation and memory splitting, highlighting the framework's potential for robust, efficient segmentation in complex surgical scenarios. Our source code will be available at https://github.com/apple1986/TSMS-SAM2.