Amanda Ding

Hamidreza Aftabi, John E. Lloyd, Amanda Ding et al.

Mandibular reconstruction with vascularized bone grafts is complicated by donor-host nonunion, and current virtual surgical planning produces a geometric plan rather than a configuration that explicitly promotes bone union. We present OsteoOpt++, an image-to-decision planning loop for patient-specific mandibular reconstruction. A pre-operative computed tomography (CT) is converted into a personalized digital twin through template-to-patient registration and CT-derived updates of the muscle and temporomandibular-joint parameters. Bayesian optimization with an expected-improvement-plus acquisition rule then searches six clinically controllable cut-plane and donor-positioning variables under an apposition-driven objective and a safety-factor-regularized variant. The workflow was evaluated on three generic defects (body, symphysis, and ramus-body) and a total of 3+1 patient-specific cases, with 3 used for optimization and 1 for validation. In the generic cases, against a common surgical approach, cycle-averaged donor-mandible apposition increased by up to 29 percentage points (329% relative); in the patient-specific cases, against the surgeon-implemented day-5 post-operative configuration, by up to 26 percentage points. A 10% sensitivity analysis over eleven modeling parameters capped the change in the apposition-driven objective at 3% for generic cases and 4% for patient-specific cases, and the longitudinal case showed Dice overlap of 0.70 and 0.76 between predicted apposition and year-1 bone formation. Clinically, this provides surgeons with a pre-operative, image-driven recommendation for cut-plane orientation and donor placement that is predicted to improve union conditions over the configurations currently delivered in the operating room. The optimization and patient-specific modeling code is open source at https://github.com/hamidreza-aftabi/OsteoOpt.

Dayu Yang, Natawut Monaikul, Amanda Ding et al.

In the era of data-driven decision-making, accurate table-level representations and efficient table recommendation systems are becoming increasingly crucial for improving table management, discovery, and analysis. However, existing approaches to tabular data representation often face limitations, primarily due to their focus on cell-level tasks and the lack of high-quality training data. To address these challenges, we first formulate a clear definition of table similarity in the context of data transformation activities within data-driven enterprises. This definition serves as the foundation for synthetic data generation, which require a well-defined data generation process. Building on this, we propose a novel synthetic data generation pipeline that harnesses the code generation and data manipulation capabilities of Large Language Models (LLMs) to create a large-scale synthetic dataset tailored for table-level representation learning. Through manual validation and performance comparisons on the table recommendation task, we demonstrate that the synthetic data generated by our pipeline aligns with our proposed definition of table similarity and significantly enhances table representations, leading to improved recommendation performance.