Rongsheng Wang

Rongsheng Wang, Yaofei Duan, ChanTong Lam et al.

General large language models (LLMs) such as ChatGPT have shown remarkable success. However, such LLMs have not been widely adopted for medical purposes, due to poor accuracy and inability to provide medical advice. We propose IvyGPT, an LLM based on LLaMA that is trained and fine-tuned with high-quality medical question-answer (QA) instances and Reinforcement Learning from Human Feedback (RLHF). After supervised fine-tuning, IvyGPT has good multi-turn conversation capabilities, but it cannot perform like a doctor in other aspects, such as comprehensive diagnosis. Through RLHF, IvyGPT can output richer diagnosis and treatment answers that are closer to human. In the training, we used QLoRA to train 33 billion parameters on a small number of NVIDIA A100 (80GB) GPUs. Experimental results show that IvyGPT has outperformed other medical GPT models.

Qimin Yang, Rongsheng Wang, Jiexin Chen et al.

Large Language Models (LLMs) have been widely applied in various professional fields. By fine-tuning the models using domain specific question and answer datasets, the professional domain knowledge and Q\&A abilities of these models have significantly improved, for example, medical professional LLMs that use fine-tuning of doctor-patient Q\&A data exhibit extraordinary disease diagnostic abilities. However, we observed that despite improvements in specific domain knowledge, the performance of medical LLM in long-context understanding has significantly declined, especially compared to general language models with similar parameters. The purpose of this study is to investigate the phenomenon of reduced performance in understanding long-context in medical LLM. We designed a series of experiments to conduct open-book professional knowledge exams on all models to evaluate their ability to read long-context. By adjusting the proportion and quantity of general data and medical data in the process of fine-tuning, we can determine the best data composition to optimize the professional model and achieve a balance between long-context performance and specific domain knowledge.

Haoran Lai, Qingsong Yao, Zihang Jiang et al.

The advancement of Zero-Shot Learning in the medical domain has been driven forward by using pre-trained models on large-scale image-text pairs, focusing on image-text alignment. However, existing methods primarily rely on cosine similarity for alignment, which may not fully capture the complex relationship between medical images and reports. To address this gap, we introduce a novel approach called Cross-Attention Alignment for Radiology Zero-Shot Classification (CARZero). Our approach innovatively leverages cross-attention mechanisms to process image and report features, creating a Similarity Representation that more accurately reflects the intricate relationships in medical semantics. This representation is then linearly projected to form an image-text similarity matrix for cross-modality alignment. Additionally, recognizing the pivotal role of prompt selection in zero-shot learning, CARZero incorporates a Large Language Model-based prompt alignment strategy. This strategy standardizes diverse diagnostic expressions into a unified format for both training and inference phases, overcoming the challenges of manual prompt design. Our approach is simple yet effective, demonstrating state-of-the-art performance in zero-shot classification on five official chest radiograph diagnostic test sets, including remarkable results on datasets with long-tail distributions of rare diseases. This achievement is attributed to our new image-text alignment strategy, which effectively addresses the complex relationship between medical images and reports. Code and models are available at https://github.com/laihaoran/CARZero.

Rongsheng Wang, Qi Li, Sihong Xie

General large language models (LLMs) such as ChatGPT have shown remarkable success, but it has also raised concerns among people about the misuse of AI-generated texts. Therefore, an important question is how to detect whether the texts are generated by ChatGPT or by humans. Existing detectors are built on the assumption that there is a distribution gap between human-generated and AI-generated texts. These gaps are typically identified using statistical information or classifiers. In contrast to prior research methods, we find that large language models such as ChatGPT exhibit strong self-consistency in text generation and continuation. Self-consistency capitalizes on the intuition that AI-generated texts can still be reasoned with by large language models using the same logical reasoning when portions of the texts are masked, which differs from human-generated texts. Using this observation, we subsequently proposed a new method for AI-generated texts detection based on self-consistency with masked predictions to determine whether a text is generated by LLMs. This method, which we call DetectGPT-SC. We conducted a series of experiments to evaluate the performance of DetectGPT-SC. In these experiments, we employed various mask scheme, zero-shot, and simple prompt for completing masked texts and self-consistency predictions. The results indicate that DetectGPT-SC outperforms the current state-of-the-art across different tasks.

Rongsheng Wang, Haoming Chen, Ruizhe Zhou et al.

ChatGPT and other general large language models (LLMs) have achieved remarkable success, but they have also raised concerns about the misuse of AI-generated texts. Existing AI-generated text detection models, such as based on BERT and RoBERTa, are prone to in-domain over-fitting, leading to poor out-of-domain (OOD) detection performance. In this paper, we first collected Chinese text responses generated by human experts and 9 types of LLMs, for which to multiple domains questions, and further created a dataset that mixed human-written sentences and sentences polished by LLMs. We then proposed LLM-Detector, a novel method for both document-level and sentence-level text detection through Instruction Tuning of LLMs. Our method leverages the wealth of knowledge LLMs acquire during pre-training, enabling them to detect the text they generate. Instruction tuning aligns the model's responses with the user's expected text detection tasks. Experimental results show that previous methods struggle with sentence-level AI-generated text detection and OOD detection. In contrast, our proposed method not only significantly outperforms baseline methods in both sentence-level and document-level text detection but also demonstrates strong generalization capabilities. Furthermore, since LLM-Detector is trained based on open-source LLMs, it is easy to customize for deployment.

Rongsheng Wang, Haoming Chen, Ruizhe Zhou et al.

Existing research has demonstrated that refining large language models (LLMs) through the utilization of machine-generated instruction-following data empowers these models to exhibit impressive zero-shot capabilities for novel tasks, without requiring human-authored instructions. In this paper, we systematically investigate, preprocess, and integrate three Chinese instruction-following datasets with the aim of enhancing the Chinese conversational capabilities of Mixtral-8x7B sparse Mixture-of-Experts model. Through instruction fine-tuning on this carefully processed dataset, we successfully construct the Mixtral-8x7B sparse Mixture-of-Experts model named "Aurora." To assess the performance of Aurora, we utilize three widely recognized benchmark tests: C-Eval, MMLU, and CMMLU. Empirical studies validate the effectiveness of instruction fine-tuning applied to Mixtral-8x7B sparse Mixture-of-Experts model. This work is pioneering in the execution of instruction fine-tuning on a sparse expert-mixed model, marking a significant breakthrough in enhancing the capabilities of this model architecture. Our code, data and model are publicly available at https://github.com/WangRongsheng/Aurora

Rongsheng Wang, Junying Chen, Ke Ji et al.

Recent advances in video generation have shown remarkable progress in open-domain settings, yet medical video generation remains largely underexplored. Medical videos are critical for applications such as clinical training, education, and simulation, requiring not only high visual fidelity but also strict medical accuracy. However, current models often produce unrealistic or erroneous content when applied to medical prompts, largely due to the lack of large-scale, high-quality datasets tailored to the medical domain. To address this gap, we introduce MedVideoCap-55K, the first large-scale, diverse, and caption-rich dataset for medical video generation. It comprises over 55,000 curated clips spanning real-world medical scenarios, providing a strong foundation for training generalist medical video generation models. Built upon this dataset, we develop MedGen, which achieves leading performance among open-source models and rivals commercial systems across multiple benchmarks in both visual quality and medical accuracy. We hope our dataset and model can serve as a valuable resource and help catalyze further research in medical video generation. Our code and data is available at https://github.com/FreedomIntelligence/MedGen

Fenghe Tang, Chengqi Dong, Wenxin Ma et al.

Over the past decade, U-Net has been the dominant architecture in medical image segmentation, leading to the development of thousands of U-shaped variants. Despite its widespread adoption, there is still no comprehensive benchmark to systematically evaluate their performance and utility, largely because of insufficient statistical validation and limited consideration of efficiency and generalization across diverse datasets. To bridge this gap, we present U-Bench, the first large-scale, statistically rigorous benchmark that evaluates 100 U-Net variants across 28 datasets and 10 imaging modalities. Our contributions are threefold: (1) Comprehensive Evaluation: U-Bench evaluates models along three key dimensions: statistical robustness, zero-shot generalization, and computational efficiency. We introduce a novel metric, U-Score, which jointly captures the performance-efficiency trade-off, offering a deployment-oriented perspective on model progress. (2) Systematic Analysis and Model Selection Guidance: We summarize key findings from the large-scale evaluation and systematically analyze the impact of dataset characteristics and architectural paradigms on model performance. Based on these insights, we propose a model advisor agent to guide researchers in selecting the most suitable models for specific datasets and tasks. (3) Public Availability: We provide all code, models, protocols, and weights, enabling the community to reproduce our results and extend the benchmark with future methods. In summary, U-Bench not only exposes gaps in previous evaluations but also establishes a foundation for fair, reproducible, and practically relevant benchmarking in the next decade of U-Net-based segmentation models. The project can be accessed at: https://fenghetan9.github.io/ubench. Code is available at: https://github.com/FengheTan9/U-Bench.

Haoran Lai, Zihang Jiang, Qingsong Yao et al.

The development of 3D medical vision-language models holds significant potential for disease diagnosis and patient treatment. However, compared to 2D medical images, 3D medical images, such as CT scans, face challenges related to limited training data and high dimension, which severely restrict the progress of 3D medical vision-language models. To address these issues, we collect a large amount of unlabeled 3D CT data and utilize self-supervised learning to construct a 3D visual foundation model for extracting 3D visual features. Then, we apply 3D spatial convolutions to aggregate and project high-level image features, reducing computational complexity while preserving spatial information. We also construct two instruction-tuning datasets based on BIMCV-R and CT-RATE to fine-tune the 3D vision-language model. Our model demonstrates superior performance compared to existing methods in report generation, visual question answering, and disease diagnosis. Code and data will be made publicly available soon.

Haoran Lai, Zihang Jiang, Qingsong Yao et al.

3D medical images such as computed tomography are widely used in clinical practice, offering a great potential for automatic diagnosis. Supervised learning-based approaches have achieved significant progress but rely heavily on extensive manual annotations, limited by the availability of training data and the diversity of abnormality types. Vision-language alignment (VLA) offers a promising alternative by enabling zero-shot learning without additional annotations. However, we empirically discover that the visual and textural embeddings after alignment endeavors from existing VLA methods form two well-separated clusters, presenting a wide gap to be bridged. To bridge this gap, we propose a Bridged Semantic Alignment (BrgSA) framework. First, we utilize a large language model to perform semantic summarization of reports, extracting high-level semantic information. Second, we design a Cross-Modal Knowledge Interaction module that leverages a cross-modal knowledge bank as a semantic bridge, facilitating interaction between the two modalities, narrowing the gap, and improving their alignment. To comprehensively evaluate our method, we construct a benchmark dataset that includes 15 underrepresented abnormalities as well as utilize two existing benchmark datasets. Experimental results demonstrate that BrgSA achieves state-of-the-art performances on both public benchmark datasets and our custom-labeled dataset, with significant improvements in zero-shot diagnosis of underrepresented abnormalities.

Rongsheng Wang, Qingsong Yao, Zihang Jiang et al.

Despite significant advancements in medical vision-language pre-training, existing methods have largely overlooked the inherent linguistic complexity and imbalanced isssue within medical reports, as well as the complex cross-modality contextual relationships between texts and images. To close this gap, we propose a novel Entity-centered Context-aware Medical Vision-language Pre-training (ECAMP) framework, which establishes a more entity-centered, context-sensitive, and balanced understanding of medical reports to effectively pre-train the vision encoder. We first distill entity-centered context from medical reports utilizing large language models, enabling ECAMP to draw more precise supervision from the text modality. By further incorporating entity-aware re-balanced factor and descriptor masking strategies into masked languange modeling, ECAMP significantly enhances the knowledge of entities within the reports. A context-guided super-resolution task is proposed alongside a multi-scale context fusion design to improve the semantic integration of both coarse and fine-level image representations, which prompts better performance for multi-scale downstream applications. ECAMP integrates these innovations together, leading to significant performance leaps over current state-of-the-art methods and establish a new standard for cross-modality pre-training in medical imaging. The effectiveness of ECAMP is demonstrated by extensive experiments on various domains and organs, which achieves cutting-edge results on multiple tasks including classification, segmentation, and detection across 5 public chest X-ray and 4 fundoscopy datasets respectively.